Fangqiu Fu
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View article: A non-invasive approach based on ultrasonography and machine learning for selective cervical lymphadenectomy in thoracic esophageal cancer
A non-invasive approach based on ultrasonography and machine learning for selective cervical lymphadenectomy in thoracic esophageal cancer Open
Background: The role of cervical lymph node dissection in esophageal squamous cell carcinoma (ESCC) surgery remains controversial. This study aims to explore a machine learning (ML) approach that integrates sonographic and clinical finding…
View article: Ten-year follow-up outcomes of resected stage II non-small cell lung cancer patients
Ten-year follow-up outcomes of resected stage II non-small cell lung cancer patients Open
Our study presents long-term follow-up results for patients with stage II NSCLC, and our findings suggest that adjuvant chemotherapy is recommended for patients with stage IIA or IIB-N0 NSCLC who have HRFs, as well as for patients with sta…
View article: Phase III Study of Mediastinal Lymph Node Dissection for Ground Glass Opacity–Dominant Lung Adenocarcinoma
Phase III Study of Mediastinal Lymph Node Dissection for Ground Glass Opacity–Dominant Lung Adenocarcinoma Open
PURPOSE Systematic mediastinal lymph node dissection (LND) or sampling is currently recommended for patients with early-stage non–small cell lung cancer. We aimed to investigate whether no mediastinal LND was noninferior to systematic LND …
View article: Comprehensive genomic and transcriptomic analyses reveal prognostic stratification for esophageal squamous cell carcinoma
Comprehensive genomic and transcriptomic analyses reveal prognostic stratification for esophageal squamous cell carcinoma Open
View article: Identification and validation of a DNA methylation-block prognostic model in non-small cell lung cancer patients
Identification and validation of a DNA methylation-block prognostic model in non-small cell lung cancer patients Open
In this study, we developed a postoperative recurrence prediction model based on preoperative tissue methylation characteristics to identify individuals in I-III stage NSCLC patients following surgical resection who may have a higher risk …
View article: Bridging the Gap in Surgery for Octogenarians With Early-Stage Lung Cancer
Bridging the Gap in Surgery for Octogenarians With Early-Stage Lung Cancer Open
View article: Active surveillance for patients with multifocal ground-glass nodules: protocol of a prospective, multi-center, single-arm trial (ECTOP-1021)
Active surveillance for patients with multifocal ground-glass nodules: protocol of a prospective, multi-center, single-arm trial (ECTOP-1021) Open
This trial is officially registered on ClinicalTrials.gov (NCT06097910).
View article: Multidisciplinary management of N2 stage III non-small cell lung cancer: opportunities and challenges for radiation oncology
Multidisciplinary management of N2 stage III non-small cell lung cancer: opportunities and challenges for radiation oncology Open
Stage III non-small cell lung cancer (NSCLC) constitutes a heterogeneous ailment, with optimal treatment evolving. This is especially true in N2 disease, where definitive treatment is often a discussion of surgery versus definitive chemora…
View article: Genomic and Transcriptomic Dynamics in the Stepwise Progression of Lung Adenocarcinoma
Genomic and Transcriptomic Dynamics in the Stepwise Progression of Lung Adenocarcinoma Open
Lung adenocarcinoma (LUAD) progresses from pre-invasive to invasive stages, as well as from ground-glass opacities (GGOs) to solid nodules. However, the dynamic genomic and transcriptomic changes underlying LUAD progression remain incomple…
View article: Genomic and immune heterogeneity of multiple synchronous lung adenocarcinoma at different developmental stages
Genomic and immune heterogeneity of multiple synchronous lung adenocarcinoma at different developmental stages Open
View article: Protocol for a single-arm, multicenter, prospective, confirmatory phase III trial of wedge resection for invasive ground glass opacity-featured lung cancer with a size ≤2 cm and a consolidation tumor ratio between 0.25 and 0.5 (ECTOP-1020 study)
Protocol for a single-arm, multicenter, prospective, confirmatory phase III trial of wedge resection for invasive ground glass opacity-featured lung cancer with a size ≤2 cm and a consolidation tumor ratio between 0.25 and 0.5 (ECTOP-1020 study) Open
This trial has been registered on ClinicalTrial.gov (No. NCT06102161).
View article: Resected lung adenocarcinoma with lymph node metastasis: is ground glass opacity component a prognostic factor?
Resected lung adenocarcinoma with lymph node metastasis: is ground glass opacity component a prognostic factor? Open
A minority of resected node-positive lung adenocarcinoma presents as GGO component on CT. The presence of GGO component does not predict better prognosis in node-positive lung adenocarcinoma.
View article: Segmentectomy for ground glass-dominant invasive lung cancer with tumour diameter of 2–3 cm: protocol for a single-arm, multicentre, phase III trial (ECTOP1012)
Segmentectomy for ground glass-dominant invasive lung cancer with tumour diameter of 2–3 cm: protocol for a single-arm, multicentre, phase III trial (ECTOP1012) Open
Introduction Previous studies demonstrated that wedge resection is sufficient for ground glass-dominant lung adenocarcinoma (LUAD) with tumour diameter ≤2 cm, however, the optimal surgical type for ground glass-dominant LUAD with tumour di…
View article: The Overlooked Cornerstone in Precise Medicine: Personalized Postoperative Surveillance Plan for NSCLC
The Overlooked Cornerstone in Precise Medicine: Personalized Postoperative Surveillance Plan for NSCLC Open
View article: Prediction of the pathological subtypes by intraoperative frozen section for patients with cT1N0M0 invasive lung adenocarcinoma (ECTOP-1015): a prospective multicenter study
Prediction of the pathological subtypes by intraoperative frozen section for patients with cT1N0M0 invasive lung adenocarcinoma (ECTOP-1015): a prospective multicenter study Open
Background: This study aims to assess the diagnostic accuracy of the intraoperative frozen section (FS) in determining the pathological subtypes among patients diagnosed with cT1N0M0 invasive lung adenocarcinoma. Materials and methods: Thi…
View article: Systemic immune index predicts tumor-infiltrating lymphocyte intensity and immunotherapy response in small cell lung cancer
Systemic immune index predicts tumor-infiltrating lymphocyte intensity and immunotherapy response in small cell lung cancer Open
This study provides a method to investigate the prognostic value of overall immune status by combining the PNI with local immune biomarkers in SCLC. The promising clinical application of PNI in efficacy prediction and beneficiary selection…
View article: Exploring diverse programmed cell-death patterns to develop a novel gene signature for predicting the prognosis of lung adenocarcinoma patients
Exploring diverse programmed cell-death patterns to develop a novel gene signature for predicting the prognosis of lung adenocarcinoma patients Open
This study identified a 9-gene signature (CDI) based on PCD-related genes that accurately predicted the prognosis of LUAD patients. The CDI could serve as a valuable prognostic indicator and guide personalized therapeutic strategies for LU…
View article: Integrative Spatial Analysis Reveals Tumor Heterogeneity and Immune Colony Niche Related to Clinical-Outcomes in Small Cell Lung Cancer
Integrative Spatial Analysis Reveals Tumor Heterogeneity and Immune Colony Niche Related to Clinical-Outcomes in Small Cell Lung Cancer Open
View article: Evolutionary proteogenomic landscape from pre-invasive to invasive lung adenocarcinoma
Evolutionary proteogenomic landscape from pre-invasive to invasive lung adenocarcinoma Open
View article: Clinical characteristics and progression of pre-/minimally invasive lung adenocarcinoma harboring ALK or RET rearrangements: a retrospective cohort study
Clinical characteristics and progression of pre-/minimally invasive lung adenocarcinoma harboring ALK or RET rearrangements: a retrospective cohort study Open
ALK/RET-positive pre-/minimally invasive lung adenocarcinomas were mostly characterized as mGGOs with cystic airspace developing rapid nodule progression, and no recurrence occurred during long-term follow-up after resection.…
View article: Resected lung adenocarcinoma with lymph node metastasis: Is ground glass opacity component a prognostic factor?
Resected lung adenocarcinoma with lymph node metastasis: Is ground glass opacity component a prognostic factor? Open
Purpose Ground glass opacity (GGO)-featured lung adenocarcinoma generally has excellent prognosis, and rarely has lymph node metastasis. We aim to explore the prognostic impact of GGO component in node-positive lung adenocarcinomas. Method…
View article: Hybrid deep multi-task learning radiomics approach for predicting EGFR mutation status of non-small cell lung cancer in CT images
Hybrid deep multi-task learning radiomics approach for predicting EGFR mutation status of non-small cell lung cancer in CT images Open
Objective. Epidermal growth factor receptor (EGFR) mutation genotyping plays a pivotal role in targeted therapy for non-small cell lung cancer (NSCLC). We aimed to develop a computed tomography (CT) image-based hybrid deep radiomics model …
View article: Residual tumor descriptors proposed by the International Association for the Study of Lung Cancer may not be applicable to stage I and ground-glass opacity-featured non-small cell lung cancer
Residual tumor descriptors proposed by the International Association for the Study of Lung Cancer may not be applicable to stage I and ground-glass opacity-featured non-small cell lung cancer Open
R(un) represented an intermediate type between R0 and R1. Our study provided an external validation for new residual tumor descriptors for NSCLC proposed by IASLC. Proposed residual tumor descriptors were applicable in radiologic solid NSC…
View article: Tumor‐derived Vimentin as a novel biomarker for distinct subtypes predicting adjuvant chemotherapy resistance and T‐cell‐inflamed phenotype in small cell lung cancer
Tumor‐derived Vimentin as a novel biomarker for distinct subtypes predicting adjuvant chemotherapy resistance and T‐cell‐inflamed phenotype in small cell lung cancer Open
Despite recent progress in subtype classification for small cell lung carcinoma (SCLC), little is known about the biomarker for triple‐negative (ASCL1, NEUROD1, and POU2F3 negative) tumors. The long‐term survival, adjuvant chemotherapy (AC…
View article: Genomic and immune heterogeneity of multiple synchronous lung adenocarcinoma at different developmental stages
Genomic and immune heterogeneity of multiple synchronous lung adenocarcinoma at different developmental stages Open
Multiple synchronous lung cancers (MSLCs) constitute a unique subtype of lung cancer. To explore the genomic and immune heterogeneity across different pathological stages of MSLCs, we analyzed 16 MSLCs from 8 patients using single-cell RNA…
View article: ASO Author Reflections: Upfront Surgery Followed by Adjuvant Therapy: An Option for IIIA-N2 Non-small Cell Lung Cancer
ASO Author Reflections: Upfront Surgery Followed by Adjuvant Therapy: An Option for IIIA-N2 Non-small Cell Lung Cancer Open
View article: Treating lung cancer: defining surgical curative time window
Treating lung cancer: defining surgical curative time window Open
View article: Prognostic effect of ground-glass opacity in subcentimeter invasive lung adenocarcinoma
Prognostic effect of ground-glass opacity in subcentimeter invasive lung adenocarcinoma Open
The radiological appearance stratified the prognosis of IAC with size of smaller than or equal to 1 cm. Sublobar resection may be feasible for subcentimeter IAC, even for those appearing as solid nodules; however, caution should be taken w…
View article: Selective Mediastinal Lymph Node Dissection Strategy for Clinical T1N0 Invasive Lung Cancer: A Prospective, Multicenter, Clinical Trial
Selective Mediastinal Lymph Node Dissection Strategy for Clinical T1N0 Invasive Lung Cancer: A Prospective, Multicenter, Clinical Trial Open
This is the first prospective trial validating the specific mediastinal LN metastasis pattern in cT1N0 invasive NSCLC, which provides important evidence for clinical applications of selective LN dissection strategy.
View article: Distribution and concordance of PD-L1 expression by routine 22C3 assays in East-Asian patients with non-small cell lung cancer
Distribution and concordance of PD-L1 expression by routine 22C3 assays in East-Asian patients with non-small cell lung cancer Open