Fudong Yu
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View article: Humidify Feedback of Wetland Changes in the China Side of the Heilongjiang River Basin
Humidify Feedback of Wetland Changes in the China Side of the Heilongjiang River Basin Open
Understanding how wetland changes affect near-surface humidity is essential for evaluating their climate-influencing functions, especially in mid- and high-latitude regions. Here, using multi-source remote sensing data, we investigated the…
View article: Neuropeptide VF promotes hypoxia-inducible factor-1<b><i>α</i></b> expression in age-related macular degeneration via the aldehyde dehydrogenase 2/D-glycerate axis
Neuropeptide VF promotes hypoxia-inducible factor-1<b><i>α</i></b> expression in age-related macular degeneration via the aldehyde dehydrogenase 2/D-glycerate axis Open
View article: SHAP-DNN Approach Advances Remote Sensing Mapping of Forested Wetlands
SHAP-DNN Approach Advances Remote Sensing Mapping of Forested Wetlands Open
Mapping the spatial distribution of forested wetlands accurately is crucial for assessing the impact of climate change on terrestrial ecosystems in the mid to high latitudes of the Northern Hemisphere. However, identifying forested wetland…
View article: Disulfidptosis-related gene expression reflects the prognosis of drug-resistant cancer patients and inhibition of MYH9 reverses sorafenib resistance
Disulfidptosis-related gene expression reflects the prognosis of drug-resistant cancer patients and inhibition of MYH9 reverses sorafenib resistance Open
The onset of drug resistance in advanced cancer patients markedly diminishes their prognosis. Recently, disulfidptosis, a novel form of cell death, has been identified, triggered by excessive disulfide formation leading to cell shrinkage a…
View article: Retraction: MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4
Retraction: MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4 Open
View article: TargetGene: a comprehensive database of cell-type-specific target genes for genetic variants
TargetGene: a comprehensive database of cell-type-specific target genes for genetic variants Open
Annotating genetic variants to their target genes is of great importance in unraveling the causal variants and genetic mechanisms that underlie complex diseases. However, disease-associated genetic variants are often located in non-coding …
View article: Modeling potential wetland distributions in China based on geographic big data and machine learning algorithms
Modeling potential wetland distributions in China based on geographic big data and machine learning algorithms Open
Climate change and human activities have reduced the area and degraded the functions and services of wetlands in China. To protect and restore wetlands, it is urgent to predict the spatial distribution of potential wetlands. In this study,…
View article: Mapping potential wetlands by a new framework method using random forest algorithm and big Earth data: A case study in China's Yangtze River Basin
Mapping potential wetlands by a new framework method using random forest algorithm and big Earth data: A case study in China's Yangtze River Basin Open
Mapping potential wetlands provides a promising approach to get such information rapidly, and thus is of great significance to understanding ecosystem sustainability and support wetland conservation and restoration. This study proposed a n…
View article: DOCK4 Is a Platinum-Chemosensitive and Prognostic-Related Biomarker in Ovarian Cancer
DOCK4 Is a Platinum-Chemosensitive and Prognostic-Related Biomarker in Ovarian Cancer Open
Ovarian carcinoma (OV) is a lethal gynecological malignancy. Most OV patients develop resistance to platinum-based chemotherapy and recurrence. Peroxisome proliferator-activated receptors (PPARs) are the ligand activating transcription fac…
View article: EFEMP1 Overexpression Contributes to Neovascularization in Age-Related Macular Degeneration
EFEMP1 Overexpression Contributes to Neovascularization in Age-Related Macular Degeneration Open
Purpose: Age-related macular degeneration (AMD) is one of the leading causes of blindness, and choroidal neovascularization (CNV) in AMD can lead to serious visual impairment. Gene expression profiling of human ocular tissues have a great …
View article: Identification of an autophagy-related gene signature predicting overall survival for hepatocellular carcinoma
Identification of an autophagy-related gene signature predicting overall survival for hepatocellular carcinoma Open
The poor prognosis of hepatocellular carcinoma (HCC) calls for the development of accurate prognostic models. The growing number of studies indicating a correlation between autophagy activity and HCC indicates there is a commitment to find…
View article: Integrated bioinformatics analysis of aberrantly-methylated differentially-expressed genes and pathways in age-related macular degeneration
Integrated bioinformatics analysis of aberrantly-methylated differentially-expressed genes and pathways in age-related macular degeneration Open
Background Age-related macular degeneration (AMD) represents the leading cause of visual impairment in the aging population. The goal of this study was to identify aberrantly-methylated, differentially-expressed genes (MDEGs) in AMD and ex…
View article: Integrated bioinformatics analysis of aberrantly-methylated differentially-expressed genes and pathways in age-related macular degeneration
Integrated bioinformatics analysis of aberrantly-methylated differentially-expressed genes and pathways in age-related macular degeneration Open
Background: Age-related macular degeneration (AMD) represents the leading cause of visual impairment in the aging population. The goal of this study was to identify aberrantly-methylated, differentially-expressed genes (MDEGs) in AMD and e…
View article: Integrated bioinformatics analysis of aberrantly-methylated differentially-expressed genes and pathways in age-related macular degeneration
Integrated bioinformatics analysis of aberrantly-methylated differentially-expressed genes and pathways in age-related macular degeneration Open
Background: Age-related macular degeneration (AMD) represents the leading cause of visual impairment in the aging population. The goal of this study was to identify aberrantly-methylated, differentially-expressed genes (MDEGs) in AMD and e…
View article: Integrated bioinformatics analysis of aberrantly methylated-differentially expressed genes and pathways in age-related macular degeneration
Integrated bioinformatics analysis of aberrantly methylated-differentially expressed genes and pathways in age-related macular degeneration Open
Background: Age-related macular degeneration (AMD) represents the leading cause of visual impairment in the aging population. The goal of this study was to identify aberrantly methylated-differentially expressed genes (MDEGs) in AMD and ex…
View article: Additional file 1 of Integrated bioinformatics analysis of aberrantly-methylated differentially-expressed genes and pathways in age-related macular degeneration
Additional file 1 of Integrated bioinformatics analysis of aberrantly-methylated differentially-expressed genes and pathways in age-related macular degeneration Open
Additional file 1: Table S1. The top 100 most significantly differentially expressed genes (DEGs) of GSE29801. To identify DEGs, we used the expression profile from GSE29801 (containing RPE-choroid and retina tissue samples from 41 patient…
View article: Additional file 3 of Integrated bioinformatics analysis of aberrantly-methylated differentially-expressed genes and pathways in age-related macular degeneration
Additional file 3 of Integrated bioinformatics analysis of aberrantly-methylated differentially-expressed genes and pathways in age-related macular degeneration Open
Additional file 3: Table S3. Identification of aberrantly methylated-differentially expressed genes (DEGs) in age-related macular degeneration (AMD). To further explore the aberrantly methylated DEGs, hypo-methylated, high-expression genes…
View article: Additional file 2 of Integrated bioinformatics analysis of aberrantly-methylated differentially-expressed genes and pathways in age-related macular degeneration
Additional file 2 of Integrated bioinformatics analysis of aberrantly-methylated differentially-expressed genes and pathways in age-related macular degeneration Open
Additional file 2: Table S2. The top 100 most significantly differentially methylated genes (DMGs) of GSE29801. To identify DMGs, we used the methylation profile from GSE102952 (containing peripheral blood samples of 9 AMD patients and 9 n…
View article: Type I interferon and interferon‐stimulated gene expression in oral epithelial cells
Type I interferon and interferon‐stimulated gene expression in oral epithelial cells Open
Oral epithelial cells (OEC) represent the first site of host interaction with viruses that infect the body through the oral route; however, their innate antiviral defense mechanisms yet to be defined. Previous studies have determined that …
View article: RPS15A promotes gastric cancer progression via activation of the Akt/IKK‐β/NF‐κB signalling pathway
RPS15A promotes gastric cancer progression via activation of the Akt/IKK‐β/NF‐κB signalling pathway Open
This study aimed to investigate the clinical significance, potential biological function and underlying mechanism of RPS15A in gastric cancer (GC) progression. RPS15A expression was detected in 40 pairs of GC tissues and matched normal gas…
View article: TRIM52 plays an oncogenic role in ovarian cancer associated with NF-kB pathway
TRIM52 plays an oncogenic role in ovarian cancer associated with NF-kB pathway Open
Emerging evidence suggests that the members of the tripartite motif (TRIM) family play a crucial role in cancer development and progression. The purpose of the study was to explore TRIM52's role in tumorigenesis and its potential molecular…
View article: System analysis of teratozoospermia mRNA profile based on integrated bioinformatics tools
System analysis of teratozoospermia mRNA profile based on integrated bioinformatics tools Open
mRNA has an important role in spermatogenesis and the maintenance of fertility, and may act as a potential biomarker for the clinical diagnosis of infertility. In the present study, potential biomarkers associated with teratozoospermia wer…
View article: Correction to: Metalloproteases meprin-ɑ (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer
Correction to: Metalloproteases meprin-ɑ (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer Open
View article: Correction: High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma
Correction: High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma Open
Figure 6: Influence of PAK7 in colon cancer cell migration and invasion.LoVo and HT29 cells were transfected with PAK7shRNA.For the cell scratch wound assay, the cultures were wounded by scratching and maintained at 37 °C for 24 h.The cell…
View article: SUMO-specific protease 3 is a key regulator for hepatic lipid metabolism in non-alcoholic fatty liver disease
SUMO-specific protease 3 is a key regulator for hepatic lipid metabolism in non-alcoholic fatty liver disease Open
Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in hepatocytes. The role of SENP3 in lipid metabolism, particularly NAFLD, is unclear. Our results showed that hepatic SENP3 was up-regulated in NAF…
View article: A comparative analysis and guidance for individualized chemotherapy of stage II and III colorectal cancer patients based on pathological markers
A comparative analysis and guidance for individualized chemotherapy of stage II and III colorectal cancer patients based on pathological markers Open
Adjuvant chemotherapy is considered the standard of care for patients with colorectal cancer after curative resection. Although current guidelines provide clear instructions for chemotherapy for stage II high-risk and stage III colorectal …
View article: Metalloproteases meprin-ɑ (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer
Metalloproteases meprin-ɑ (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer Open
MEP1A was not only found to be functionally important, but it might also serve as an important and unique indicator of patient prognosis and therapeutic targeting in CRC.
View article: High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma
High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma Open
P21 protein (Cdc42/Rac)-activated kinase 7 (PAK7) can promote neurite outgrowth, induce microtubule stabilization, and activate cell survival signaling pathways. PAK7 expression was found to increase with colon carcinoma progression, but t…
View article: MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4
MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4 Open
miR-20a-5p, as an onco-miRNA, promoted the invasion and metastasis ability by suppressing Smad4 expression in CRC cells, and high miR-20a-5p predicted poor prognosis for CRC patients, providing a novel and promising therapeutic target in h…
View article: Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer
Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer Open
Several members of the sirtuin family (SIRT1-7), which are a highly conserved family of NAD+-dependent enzymes, play an important role in tumor formation. Recent studies indicate that SIRT4 acts as a tumor suppressor by regulating glutamin…