Fangyang Wang
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View article: Radionuclide‐Activated Luminescence for Cancer Theranostics
Radionuclide‐Activated Luminescence for Cancer Theranostics Open
Within dielectric media, charged particles emitted from medical radionuclides induce polarization of surrounding molecules, which subsequently generate Cerenkov luminescence (CL) upon returning to their ground state. This CL emission confe…
View article: Supplementary Figures 1-12 and Tables S1-S2 from Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation
Supplementary Figures 1-12 and Tables S1-S2 from Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation Open
Fig. S1: BTK mutations detected in cDNA in five FL BTK mutant cases. Fig. S2:BTK mutations destabilize the mutant BTK proteins. Fig. S3:BTK mutations do not influence PLCγ2-1217 phosphorylation in reconstituted lymphoma cell lines. Fig. S…
View article: Supplementary Figures 1-12 and Tables S1-S2 from Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation
Supplementary Figures 1-12 and Tables S1-S2 from Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation Open
Fig. S1: BTK mutations detected in cDNA in five FL BTK mutant cases. Fig. S2:BTK mutations destabilize the mutant BTK proteins. Fig. S3:BTK mutations do not influence PLCγ2-1217 phosphorylation in reconstituted lymphoma cell lines. Fig. S…
View article: Supplementary Data Table S2 from Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation
Supplementary Data Table S2 from Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation Open
Results from IP-mass spec of HA-BTK WT and two HA-BTK mutants and a control (BTK-/- reconstituted with empty vector FG9) and embedded VENN diagram
View article: Data from Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation
Data from Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation Open
Purpose:On the basis of the recent discovery of mutations in Bruton tyrosine kinase (BTK) in follicular lymphoma, we studied their functional properties.Experimental Design:We identified novel somatic BTK mutations in 7% of a combined tota…
View article: Data from Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation
Data from Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation Open
Purpose:On the basis of the recent discovery of mutations in Bruton tyrosine kinase (BTK) in follicular lymphoma, we studied their functional properties.Experimental Design:We identified novel somatic BTK mutations in 7% of a combined tota…
View article: Supplementary Data Table S1 from Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation
Supplementary Data Table S1 from Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation Open
Mutations and associated characteristics of 10 FL cases with BTK mutations
View article: Supplementary Data from Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation
Supplementary Data from Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation Open
Supplementary Figure and Table legends
View article: Supplementary Data Table S1 from Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation
Supplementary Data Table S1 from Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation Open
Mutations and associated characteristics of 10 FL cases with BTK mutations
View article: Supplementary Data from Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation
Supplementary Data from Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation Open
Supplementary Figure and Table legends
View article: Supplementary Data Table S2 from Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation
Supplementary Data Table S2 from Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation Open
Results from IP-mass spec of HA-BTK WT and two HA-BTK mutants and a control (BTK-/- reconstituted with empty vector FG9) and embedded VENN diagram
View article: Mutations in V-ATPase in follicular lymphoma activate autophagic flux creating a targetable dependency
Mutations in V-ATPase in follicular lymphoma activate autophagic flux creating a targetable dependency Open
The recent discovery of recurrent gene mutations in chaperones or components of the vacuolar-type H+-translocating ATPase (V-ATPase) in follicular lymphoma (FL) was an unexpected finding. The application of whole exome sequencing and targe…
View article: Follicular lymphoma-associated mutations in the V-ATPase chaperone VMA21 activate autophagy creating a targetable dependency
Follicular lymphoma-associated mutations in the V-ATPase chaperone VMA21 activate autophagy creating a targetable dependency Open
The discovery of recurrent mutations in subunits and regulators of the vacuolar-type H+-translocating ATPase (V-ATPase) in follicular lymphoma (FL) highlights a role for macroautophagy/autophagy, amino-acid, and nutrient-sensing pathways i…
View article: Follicular lymphoma-associated mutations in the V-ATPase chaperone VMA21 activate autophagy creating a targetable dependency
Follicular lymphoma-associated mutations in the V-ATPase chaperone VMA21 activate autophagy creating a targetable dependency Open
The discovery of recurrent mutations in subunits and regulators of the vacuolar-type H+-translocating ATPase (V-ATPase) in follicular lymphoma (FL) highlights a role for macroautophagy/autophagy, amino-acid, and nutrient-sensing pathways i…
View article: Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation
Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation Open
Purpose: On the basis of the recent discovery of mutations in Bruton tyrosine kinase (BTK) in follicular lymphoma, we studied their functional properties. Experimental Design: We identified novel somatic BTK mutations in 7% of a combined t…
View article: Chronic Hypoperfusion is not Associated with Cerebral Amyloidosis
Chronic Hypoperfusion is not Associated with Cerebral Amyloidosis Open
Background Insufficient cerebral perfusion is suggested to play a role in the development of AD. We investigated the effect of chronic cerebral hypoperfusion on AD-related pathology, including β-amyloid (Aβ) deposition and brain atrophy in…
View article: Targeting procaspase‐3 with <scp>WF</scp>‐208, a novel <scp>PAC</scp>‐1 derivative, causes selective cancer cell apoptosis
Targeting procaspase‐3 with <span>WF</span>‐208, a novel <span>PAC</span>‐1 derivative, causes selective cancer cell apoptosis Open
Caspase‐3 is a critical effector caspase in apoptosis cascade, and is often over‐expressed in many cancer tissues. The first synthesized procaspase‐3 activator, PAC ‐1, induces cancer cell apoptosis and exhibits antitumour activity in muri…