Explanipedia

Supporting Video 01 from Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5–Inhibitor Complexes Open

Rose‐Laure Indorato, Sandeep K. Talapatra, Fangzhu Lin, Shozeb Haider, Simon P. Mackay , et al. · 2023

Time lapse imaging of untreated U2OS cells followed for 16h. Cells divide normally.

Suporting Video Legends from Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5–Inhibitor Complexes Open

Rose‐Laure Indorato, Sandeep K. Talapatra, Fangzhu Lin, Shozeb Haider, Simon P. Mackay , et al. · 2023

SV1-SV6: Time lapse imaging of untreated, Arry-520 and ispinesib treated naive U2OS cells, Eg5(D130) and Eg5(L214) expressing U2OS cells followed for 16h. SV7-SV12: Molecular dynamics simulations of either Eg5(WT), or Eg5(D130) or Eg5(L214…

Supporting Video 11 from Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5–Inhibitor Complexes Open

Rose‐Laure Indorato, Sandeep K. Talapatra, Fangzhu Lin, Shozeb Haider, Simon P. Mackay , et al. · 2023

Molecular dynamics simulations of the Eg5(D130A)-Arry-520 complex.

Supporting Video 10 from Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5–Inhibitor Complexes Open

Rose‐Laure Indorato, Sandeep K. Talapatra, Fangzhu Lin, Shozeb Haider, Simon P. Mackay , et al. · 2023

Molecular dynamics simulations of the Eg5(L214A)-ispinesib complex.

Supporting Video 09 from Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5–Inhibitor Complexes Open

Rose‐Laure Indorato, Sandeep K. Talapatra, Fangzhu Lin, Shozeb Haider, Simon P. Mackay , et al. · 2023

Molecular dynamics simulations of the Eg5(L214A)-Arry-520 complex.

Supporting Video 08 from Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5–Inhibitor Complexes Open

Rose‐Laure Indorato, Sandeep K. Talapatra, Fangzhu Lin, Shozeb Haider, Simon P. Mackay , et al. · 2023

Molecular dynamics simulations of the wild type Eg5-ispinesib complex.

Supporting Video 08 from Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5–Inhibitor Complexes Open

Rose‐Laure Indorato, Sandeep K. Talapatra, Fangzhu Lin, Shozeb Haider, Simon P. Mackay , et al. · 2023

Molecular dynamics simulations of the wild type Eg5-ispinesib complex.

Supplementary Table 1 and Supplementary Figures 1-3 from Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5–Inhibitor Complexes Open

Rose‐Laure Indorato, Sandeep K. Talapatra, Fangzhu Lin, Shozeb Haider, Simon P. Mackay , et al. · 2023

Table S1: Crystallographic table of data corresponding to the Eg5-Arry-520 complexes. Figure S1: Interactions of the inhibitor and conformational changes upon inhibitor binding. Figure S2: Surface representation of the allosteric inhibitor…

Supporting Video 07 from Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5–Inhibitor Complexes Open

Rose‐Laure Indorato, Sandeep K. Talapatra, Fangzhu Lin, Shozeb Haider, Simon P. Mackay , et al. · 2023

Molecular dynamics simulations of the wild type Eg5-Arry-520 complex.

Supporting Video 07 from Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5–Inhibitor Complexes Open

Rose‐Laure Indorato, Sandeep K. Talapatra, Fangzhu Lin, Shozeb Haider, Simon P. Mackay , et al. · 2023

Molecular dynamics simulations of the wild type Eg5-Arry-520 complex.

Supporting Video 06 from Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5–Inhibitor Complexes Open

Rose‐Laure Indorato, Sandeep K. Talapatra, Fangzhu Lin, Shozeb Haider, Simon P. Mackay , et al. · 2023

Time lapse imaging of U2OS-Eg5(L214A) expressing cells exposed to 10 nM ispinesib and followed for 16h. Cells are arrested in mitosis.