Fanni Bugyi
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View article: Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without <i>ALK</i> , <i>EGFR</i> , and <i>KRAS</i> genetic alterations
Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without <i>ALK</i> , <i>EGFR</i> , and <i>KRAS</i> genetic alterations Open
Genetic alterations in key oncogenes have been frequently identified in lung adenocarcinoma (LUAD), including genes encoding epidermal growth factor receptor ( EGFR ), Kirsten rat sarcoma viral oncogene homolog ( KRAS ), and anaplastic lym…
View article: Analysis and characterization of chondroitin/dermatan sulfate composition of lung adenocarcinoma tissues with different types of genetic alterations in ALK, EGFR and KRAS oncogenes
Analysis and characterization of chondroitin/dermatan sulfate composition of lung adenocarcinoma tissues with different types of genetic alterations in ALK, EGFR and KRAS oncogenes Open
Lung cancer is among the most commonly diagnosed cancer types worldwide. Studying the molecular changes underlying lung cancer is crucial for understanding tumor formation and identifying new therapeutic targets and early markers of the di…
View article: Glycoproteomics Analysis of Triple Wild-Type Lung Adenocarcinoma Tissue Samples
Glycoproteomics Analysis of Triple Wild-Type Lung Adenocarcinoma Tissue Samples Open
Lung cancer has both high incidence and mortality, making it the leading cause of cancer-related mortality worldwide. It is a highly heterogeneous disease, with several histological subtypes and genetic alterations that influence prognosis…
View article: Optimization of reversed‐phase solid‐phase extraction for shotgun proteomics analysis By Fanni Bugyi, Lilla Turiák, László Drahos and Gábor Tóth
Optimization of reversed‐phase solid‐phase extraction for shotgun proteomics analysis By Fanni Bugyi, Lilla Turiák, László Drahos and Gábor Tóth Open
Her research focuses on analytical method developments in chromatography and mass spectrometry to characterize small tissue sections and biopsies using proteomics, glycoproteomics, phosphoproteomics and glycosaminoglycan analysis to identi…
View article: Optimization of reversed‐phase solid‐phase extraction for shotgun proteomics analysis
Optimization of reversed‐phase solid‐phase extraction for shotgun proteomics analysis Open
Reversed‐phase solid‐phase extraction (SPE) is the method of choice for the purification of proteomics samples. Even though the efficacy of SPE methods is sample type‐dependent, the manufacturers' protocols are used in most studies. Using …
View article: Comparison of solid-phase extraction methods for efficient purification of phosphopeptides with low sample amounts
Comparison of solid-phase extraction methods for efficient purification of phosphopeptides with low sample amounts Open
Efficient phosphoproteomic analysis of small amounts of biological samples (e.g. tissue biopsies) requires carefully selected enrichment and purification steps prior to the nanoflow HPLC-MS/MS analysis. Solid-phase extraction (SPE) is one …
View article: Optimized Sample Preparation and Microscale Separation Methods for High-Sensitivity Analysis of Hydrophilic Peptides
Optimized Sample Preparation and Microscale Separation Methods for High-Sensitivity Analysis of Hydrophilic Peptides Open
The optimization of solid-phase extraction (SPE) purification and chromatographic separation is usually neglected during proteomics studies. However, the effects on detection performance are not negligible, especially when working with hig…
View article: Proteomic Analysis of Lung Cancer Types—A Pilot Study
Proteomic Analysis of Lung Cancer Types—A Pilot Study Open
Lung cancer is the leading cause of tumor-related mortality, therefore significant effort is directed towards understanding molecular alterations occurring at the origin of the disease to improve current treatment options. The aim of our p…
View article: Influence of Post-Translational Modifications on Protein Identification in Database Searches
Influence of Post-Translational Modifications on Protein Identification in Database Searches Open
Comprehensive analysis of post-translation modifications (PTMs) is an important mission of proteomics. However, the consideration of PTMs increases the search space and may therefore impair the efficiency of protein identification. Using t…
View article: Selective TiO2 Phosphopeptide Enrichment of Complex Samples in the Nanogram Range
Selective TiO2 Phosphopeptide Enrichment of Complex Samples in the Nanogram Range Open
Phosphopeptide enrichment is a commonly used sample preparation step for investigating phosphorylation. TiO2-based enrichment has been demonstrated to have excellent performance both for large amounts of complex and for small amounts of si…