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View article: EGFL7 promotes immune evasion in glioma through its interaction with integrin β<sub>2</sub>
EGFL7 promotes immune evasion in glioma through its interaction with integrin β<sub>2</sub> Open
Glioblastoma is the most aggressive form of malignant brain cancer, characterized by an immunosuppressive microenvironment and extensive angiogenesis. Epidermal growth factor-like protein 7 (EGFL7), a secreted pro-angiogenic factor that is…
View article: Exploring social modulation: Microglia as a key mediator of individual immune response, plasticity and pathology in App-NL-G-F mouse model of Alzheimer’s disease
Exploring social modulation: Microglia as a key mediator of individual immune response, plasticity and pathology in App-NL-G-F mouse model of Alzheimer’s disease Open
This study explores the influence of lifestyle on Alzheimer’s disease (AD) progression using App-NL-G-F mice in a complex enrichment system. Mice exhibited social deficits before plaque pathology or memory impairment, revealing a crucial l…
View article: Presymptomatic Reduction of Individuality in the AppNL-F Knockin Model of Alzheimer’s Disease
Presymptomatic Reduction of Individuality in the AppNL-F Knockin Model of Alzheimer’s Disease Open
View article: The individuality paradigm: Automated longitudinal activity tracking of large cohorts of genetically identical mice in an enriched environment
The individuality paradigm: Automated longitudinal activity tracking of large cohorts of genetically identical mice in an enriched environment Open
View article: Pre-symptomatic reduction of individuality in the App<sup>NL-F</sup> knock-in model of Alzheimer’s disease
Pre-symptomatic reduction of individuality in the App<sup>NL-F</sup> knock-in model of Alzheimer’s disease Open
While one third of the risk for Alzheimer’s disease (AD) is explained by environment and lifestyle, AD pathology also affects individual lifestyle, possibly long before clinical manifestation of dementia. To study this hidden disease effec…
View article: Notch3-Dependent Effects on Adult Neurogenesis and Hippocampus-Dependent Learning in a Modified Transgenic Model of CADASIL
Notch3-Dependent Effects on Adult Neurogenesis and Hippocampus-Dependent Learning in a Modified Transgenic Model of CADASIL Open
We and others have reported that Notch3 is a regulator of adult hippocampal neurogenesis. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), the most common genetic form of vascular dement…
View article: Static and dynamic 3D culture of neural precursor cells on macroporous cryogel microcarriers
Static and dynamic 3D culture of neural precursor cells on macroporous cryogel microcarriers Open
View article: Selective increases in inter-individual variability in response to environmental enrichment in female mice
Selective increases in inter-individual variability in response to environmental enrichment in female mice Open
One manifestation of individualization is a progressively differential response of individuals to the non-shared components of the same environment. Individualization has practical implications in the clinical setting, where subtle differe…
View article: Author response: Selective increases in inter-individual variability in response to environmental enrichment in female mice
Author response: Selective increases in inter-individual variability in response to environmental enrichment in female mice Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract One manifestation of individu…
View article: Selective increases in inter-individual variability in response to environmental enrichment
Selective increases in inter-individual variability in response to environmental enrichment Open
One manifestation of individualization is a progressively differential response of individuals to the non-shared components of the same environment. Individualization has practical implications in clinical setting, where subtle differences…
View article: A co-culture model of the hippocampal neurogenic niche reveals differential effects of astrocytes, endothelial cells and pericytes on proliferation and differentiation of adult murine precursor cells
A co-culture model of the hippocampal neurogenic niche reveals differential effects of astrocytes, endothelial cells and pericytes on proliferation and differentiation of adult murine precursor cells Open
The niche concept of stem cell biology proposes a functional unit between the precursor cells and their local microenvironment, to which several cell types might contribute by cell-cell contacts, extracellular matrix, and humoral factors. …