Fanny Rocher
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View article: Safety profile of belatacept in a real-life setting: disproportionality analysis of the WHO pharmacovigilance database
Safety profile of belatacept in a real-life setting: disproportionality analysis of the WHO pharmacovigilance database Open
View article: Immune checkpoint inhibitor-associated myocarditis: a novel risk score
Immune checkpoint inhibitor-associated myocarditis: a novel risk score Open
Background and Aims Immune checkpoint inhibitors (ICI) are associated with life-threatening myocarditis but milder presentations are increasingly recognized. The same autoimmune process that causes ICI myocarditis can manifest concurrent g…
View article: Evaluating and leveraging large language models in clinical pharmacology and therapeutics assessment: From exam takers to exam shapers
Evaluating and leveraging large language models in clinical pharmacology and therapeutics assessment: From exam takers to exam shapers Open
Aims In medical education, the ability of large language models (LLMs) to match human performance raises questions about their potential as educational tools. This study evaluates LLMs' performance on Clinical Pharmacology and Therapeutics…
View article: PDL1 inhibitors may be associated with a lower risk of allograft rejection than PD1 and CTLA4 inhibitors: analysis of the WHO pharmacovigilance database
PDL1 inhibitors may be associated with a lower risk of allograft rejection than PD1 and CTLA4 inhibitors: analysis of the WHO pharmacovigilance database Open
Background Transplant recipients face increased cancer mortality due to immunosuppressive treatments. Immune checkpoint inhibitors (ICI) have improved survival rates, but data on the use of these agents in transplant recipients is scarce. …
View article: Early Detection of Hearing Impairment Signals Post-mRNA COVID-19 Vaccination: A Disproportionality Analysis Study on French Pharmacovigilance Database
Early Detection of Hearing Impairment Signals Post-mRNA COVID-19 Vaccination: A Disproportionality Analysis Study on French Pharmacovigilance Database Open
View article: Lipschütz ulcer following first dose of <scp>COVID</scp>‐19 tozinameran vaccine: Report of a case and review of a World Health Organization pharmacovigilance database
Lipschütz ulcer following first dose of <span>COVID</span>‐19 tozinameran vaccine: Report of a case and review of a World Health Organization pharmacovigilance database Open
Lipschütz ulcer (LU) is a condition known for painful vulvar ulcers, typically affecting young women and often linked to infectious agents. Recent reports have indicated a potential connection between LU and COVID‐19 vaccination, particula…
View article: Teprotumumab for the Treatment of Thyroid Eye Disease: Why Should We Keep Our Eyes “Wide Open”?—A Clinical and Pharmacovigilance Point of View
Teprotumumab for the Treatment of Thyroid Eye Disease: Why Should We Keep Our Eyes “Wide Open”?—A Clinical and Pharmacovigilance Point of View Open
Objectives: Thyroid eye disease (TED) treatment has been recently revolutionized with the approval of teprotumumab, a targeted insulin growth factor 1 receptor (IGF1R) inhibitor. To date, teprotumumab is the only FDA-approved drug for trea…
View article: Dental Adverse Effects of Anti-CD20 Therapies
Dental Adverse Effects of Anti-CD20 Therapies Open
To our knowledge, this is the first case series reporting dental conditions developed in patients long-term treated with anti-CD20 treatments. This issue, literature data, and Vigilyze® analysis might be considered a safety signal that nec…
View article: Publisher Correction: Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis
Publisher Correction: Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis Open
View article: Author Correction: Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis
Author Correction: Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis Open
View article: Onset and Relapse of Depressive Disorders Associated With Wegovy® For Weight Loss
Onset and Relapse of Depressive Disorders Associated With Wegovy® For Weight Loss Open
View article: Cardiomuscular Biomarkers in the Diagnosis and Prognostication of Immune Checkpoint Inhibitor Myocarditis
Cardiomuscular Biomarkers in the Diagnosis and Prognostication of Immune Checkpoint Inhibitor Myocarditis Open
BACKGROUND: Immune checkpoint inhibitors (ICIs) are approved for multiple cancers but can result in ICI-associated myocarditis, an infrequent but life-threatening condition. Elevations in cardiac biomarkers, specifically troponin-I (cTnI),…
View article: Pharmacovigilance follow-up of patients in the context of the COVID-19 pandemic
Pharmacovigilance follow-up of patients in the context of the COVID-19 pandemic Open
View article: Sphingosine-1 Phosphate Receptor Modulators Increase In Vitro Melanoma Cell Line Proliferation at Therapeutic Doses Used in Patients with Multiple Sclerosis
Sphingosine-1 Phosphate Receptor Modulators Increase In Vitro Melanoma Cell Line Proliferation at Therapeutic Doses Used in Patients with Multiple Sclerosis Open
View article: Drug-Associated Parosmia: New Perspectives from the WHO Safety Database
Drug-Associated Parosmia: New Perspectives from the WHO Safety Database Open
Parosmia is a qualitative distortion of smell perception. Resulting from central causes, sinonasal diseases, and infections, parosmia has also been associated with medications. Therefore, we aimed to investigate potential signals for drugs…
View article: Medications as a Trigger of Sleep-Related Eating Disorder: A Disproportionality Analysis
Medications as a Trigger of Sleep-Related Eating Disorder: A Disproportionality Analysis Open
Sleep-related eating disorder (SRED) is a parasomnia with recurrent, involuntary, amnestic eating episodes during sleep. There is growing evidence of the association between SRED and medications. Therefore, we aimed to rank drugs showing t…
View article: Adverse Drug Reactions of Olanzapine, Clozapine and Loxapine in Children and Youth: A Systematic Pharmacogenetic Review
Adverse Drug Reactions of Olanzapine, Clozapine and Loxapine in Children and Youth: A Systematic Pharmacogenetic Review Open
Children and youth treated with antipsychotic drugs (APs) are particularly vulnerable to adverse drug reactions (ADRs) and prone to poor treatment response. In particular, interindividual variations in drug exposure can result from differe…
View article: COVID-19 Vaccine-Associated Transient Global Amnesia: A Disproportionality Analysis of the WHO Safety Database
COVID-19 Vaccine-Associated Transient Global Amnesia: A Disproportionality Analysis of the WHO Safety Database Open
Coronavirus disease 2019 (COVID-19) spread rapidly, resulting in a global pandemic for which vaccines were quickly developed. As their safety continues to be monitored, cases of transient global amnesia (TGA) following mRNA vaccination wit…
View article: Drug-Induced Tubulointerstitial Nephritis: Insights From the World Health Organization Safety Database
Drug-Induced Tubulointerstitial Nephritis: Insights From the World Health Organization Safety Database Open
View article: Protocol: Adverse Drug Reactions of Olanzapine, Clozapine and Loxapine in Children and Youth: A Systematic Pharmacogenetic Review
Protocol: Adverse Drug Reactions of Olanzapine, Clozapine and Loxapine in Children and Youth: A Systematic Pharmacogenetic Review Open
Review question / Objective: In children and youth treated with olanzapine, clozapine, or loxapine and having undergone genotyping, which are the pharmacogenetic variants underlying the antipsychotics' adverse drug reactions and efficacy? …
View article: Calcitonin gene-related peptide-targeting drugs and Raynaud’s phenomenon: a real-world potential safety signal from the WHO pharmacovigilance database
Calcitonin gene-related peptide-targeting drugs and Raynaud’s phenomenon: a real-world potential safety signal from the WHO pharmacovigilance database Open
View article: Risk factors associated with immune checkpoint inhibitor–induced acute kidney injury compared with other immune-related adverse events: a case–control study
Risk factors associated with immune checkpoint inhibitor–induced acute kidney injury compared with other immune-related adverse events: a case–control study Open
Background Immune checkpoint inhibitors (ICIs) foster anti-cancer immune responses. Their efficacy comes at the cost of immune-related adverse events (IRAEs). The latter affects various organs, including kidneys, mostly as acute tubulointe…
View article: Case Report: Severe Hypercalcemia Following Vitamin D Intoxication in an Infant, the Underestimated Danger of Dietary Supplements
Case Report: Severe Hypercalcemia Following Vitamin D Intoxication in an Infant, the Underestimated Danger of Dietary Supplements Open
Vitamin D supplementation is routinely introduced in infants, according to medical guidelines. However, vitamin D overdose can result in life-threatening hypercalcemia. We report the case of a 3-month-old infant who suffered from severe hy…
View article: Myopathie nécrosante chez un patient atteint d’un mélanome avancé traité par immunothérapie après une vaccination contre la COVID-19
Myopathie nécrosante chez un patient atteint d’un mélanome avancé traité par immunothérapie après une vaccination contre la COVID-19 Open
View article: Severe necrotizing myopathy after COVID‐19 vaccine with BNT162b2 and regimen with ipilimumab plus nivolumab in a patient with advanced melanoma
Severe necrotizing myopathy after COVID‐19 vaccine with BNT162b2 and regimen with ipilimumab plus nivolumab in a patient with advanced melanoma Open
Dear Editor, Immune checkpoint inhibitors (ICIs) have dramatically changed the prognosis of advanced melanoma patients, but also exposed them to immune-related adverse events (irAEs).1 Furthermore, with the combination ipilimumab (IPI) plu…
View article: Immune checkpoint inhibitors-induced nephropathy: a French national survey
Immune checkpoint inhibitors-induced nephropathy: a French national survey Open
View article: Patterns of medication errors involving pediatric population reported to the French Medication Error Guichet
Patterns of medication errors involving pediatric population reported to the French Medication Error Guichet Open
Background: Medication error is a global threat to patient safety, particularly in pediatrics. Yet, this issue remains understudied in this population, in both hospital and community settings. Objectives: To characterize medication errors …
View article: Spontaneous reported cardiotoxicity induced by lopinavir/ritonavir in COVID-19. An alleged past-resolved problem
Spontaneous reported cardiotoxicity induced by lopinavir/ritonavir in COVID-19. An alleged past-resolved problem Open
View article: Insights on the Evidence of Cardiotoxicity of Hydroxychloroquine Prior and During COVID‐19 Epidemic
Insights on the Evidence of Cardiotoxicity of Hydroxychloroquine Prior and During COVID‐19 Epidemic Open
The recent empirical use of hydroxychloroquine (HCQ) in coronavirus disease 2019 (COVID‐19) revived the interest in its cardiac toxicity, increasingly sidelined over time. We aimed to assess and compare the profile of cardiac adverse drug …
View article: Case Report: Successful Treatment of Steroid-Refractory Immune Checkpoint Inhibitor-Related Pure Red Cell Aplasia With Cyclosporin
Case Report: Successful Treatment of Steroid-Refractory Immune Checkpoint Inhibitor-Related Pure Red Cell Aplasia With Cyclosporin Open
Anemia associated with Immune checkpoint inhibitor (ICI) is usually hemolytic and regenerative. Cases of non-regenerative pure red cell aplasia are rare, and typically improve upon drug discontinuation and after corticotherapy. We herein r…