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View article: Amlodipine exerts inhibitory effects against glioma stem cells through degrading EGFR and down-regulating its downstream pro-survival pathways
Amlodipine exerts inhibitory effects against glioma stem cells through degrading EGFR and down-regulating its downstream pro-survival pathways Open
Glioblastoma is the most aggressive and lethal primary brain tumor in adults with the poorest prognosis, due to its high therapeutic resistance and rapid recurrence, which is closely associated with glioma stem cells (GSCs), which represen…
View article: Generative AI's Impact on Knowledge Ownership: Ensuring Fair IP Attribution
Generative AI's Impact on Knowledge Ownership: Ensuring Fair IP Attribution Open
With the in-depth application of generative artificial intelligence (Gen AI) in the field of knowledge management (KM), the traditional intellectual property (IP) system is facing serious challenges. The AI-driven knowledge production mode…
View article: An Elucidation of the Anti-Photoaging Efficacy and Molecular Mechanisms of Epigallocatechin Gallate Nanoparticles in a Balb/c Murine Model
An Elucidation of the Anti-Photoaging Efficacy and Molecular Mechanisms of Epigallocatechin Gallate Nanoparticles in a Balb/c Murine Model Open
With the increasing frequency of ultraviolet (UV) exposure in daily life and the exploration of anti-photoaging strategies, natural plant-derived compounds with anti-skin-aging properties have garnered significant attention. This study aim…
View article: Dihydromyricetin May Attenuate Skin Aging as a RAGE Inhibitor
Dihydromyricetin May Attenuate Skin Aging as a RAGE Inhibitor Open
Background/Objectives: Dihydromyricetin (DHM), a flavonoid with abundant natural sources, potent bioactivity, and high safety, holds promise for translational applications, particularly in mitigating skin aging. However, its role and under…
View article: Adverse event profile of crizotinib in real-world from the FAERS database: a 12-year pharmacovigilance study
Adverse event profile of crizotinib in real-world from the FAERS database: a 12-year pharmacovigilance study Open
Crizotinib offers therapeutic benefits but is also accompanied by various risks in the form of AEs. Our study findings align with previous clinical observations, and furthermore, we have identified unforeseen serious AEs. This discovery se…
View article: Implementing deep learning-based disruption prediction in a drifting data environment of new tokamak: HL-3
Implementing deep learning-based disruption prediction in a drifting data environment of new tokamak: HL-3 Open
A deep learning-based disruption prediction algorithm has been implemented on a new tokamak, HL-3. An Area Under receiver-operator characteristic Curve of 0.940 has been realized offline over a test campaign involving 72 disruptive and 240…
View article: High-beta disruption prediction study on HL-2A with instance-based transfer learning
High-beta disruption prediction study on HL-2A with instance-based transfer learning Open
Unmitigated disruptions pose a much more serious threat when large-scale tokamaks are operating in the high performance regime. Machine learning based disruption predictors can exhibit impressive performance. However, their effectiveness i…
View article: The CMS Level-1 electron and photon trigger: for Run II of LHC
The CMS Level-1 electron and photon trigger: for Run II of LHC Open
The Compact Muon Solenoid (CMS) employs a sophisticated two-level online triggering system that has a rejection factor of up to 105. Since the beginning of Run II of LHC, the conditions that CMS operates in have become increasingly challen…