Fanxiao Liu
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View article: The Alterations in the Osteoimmune Microenvironment of STZ-Induced Type 2 Diabetic Mice:A Single-Cell RNA Sequencing Analysis
The Alterations in the Osteoimmune Microenvironment of STZ-Induced Type 2 Diabetic Mice:A Single-Cell RNA Sequencing Analysis Open
Single-cell RNA sequencing provides a comprehensive profile of bone marrow immune cells in T2D mice and has highlighted their heterogeneity, population shifts, and intercellular interactions. These findings highlight critical alterations i…
View article: A new anatomical plate fixation verse dual plates fixation in the treatment of extra-articular distal humeral fractures: a retrospective study of 30 cases
A new anatomical plate fixation verse dual plates fixation in the treatment of extra-articular distal humeral fractures: a retrospective study of 30 cases Open
Background The study aims to evaluate the clinical and functional outcomes of extra-articular distal humeral fractures (EADHFs) treated with a new anatomical plate compared with dual plates-plate fixation. Methods From January 2018 to June…
View article: Tranexamic acid: A strategy to decrease postoperative drainage in elbow arthrolysis while preserving joint function
Tranexamic acid: A strategy to decrease postoperative drainage in elbow arthrolysis while preserving joint function Open
Background The study aims to evaluate the influence of tranexamic acid (TXA) on clinical outcomes in patients with elbow stiffness undergoing elbow arthrolysis. Methods A systematic review of records up to December 2024 was conducted to sc…
View article: The addition of vitamin E could reduce femoral head penetration of the polyethylene liners
The addition of vitamin E could reduce femoral head penetration of the polyethylene liners Open
View article: Biomechanical analysis of a short femoral stem used in revision total hip replacement of a standard femoral stem
Biomechanical analysis of a short femoral stem used in revision total hip replacement of a standard femoral stem Open
Short-stem total hip arthroplasty (SHA) has become popular because it preserves femoral bone stock and enables the use of short femoral stems in revision total hip arthroplasty (THA). However, no study has evaluated whether a short stem in…
View article: Novel Clinical Insights into the Pathogenesis of Posttraumatic Elbow Stiffness: An Expression Profile Analysis of Contracted Joint Capsule in Human
Novel Clinical Insights into the Pathogenesis of Posttraumatic Elbow Stiffness: An Expression Profile Analysis of Contracted Joint Capsule in Human Open
The study provided insights into the molecular mechanisms underlying the changes in the contracted capsules associated with posttraumatic elbow stiffness. Hub genes including SPP1, IBSP, MMP13, and MYO1A, key microRNAs (has-miR-186-5p, has…
View article: Comparative study of open elbow arthrolysis with and without hinge external fixation for the treatment of post-traumatic elbow stiffness
Comparative study of open elbow arthrolysis with and without hinge external fixation for the treatment of post-traumatic elbow stiffness Open
View article: Are all cases of floating hip the same? Further understanding of floating hip
Are all cases of floating hip the same? Further understanding of floating hip Open
View article: Management of extra-articular fracture of the distal humerus with the upside-down use of PHILOS plates in front of the humerus: a retrospective study of 20 patients after 28.3 months
Management of extra-articular fracture of the distal humerus with the upside-down use of PHILOS plates in front of the humerus: a retrospective study of 20 patients after 28.3 months Open
View article: Nice knots assistance in comminuted and displaced clavicle fractures reduce intraoperative blood and shorten operation time with a satisfactory postoperative clinical outcome
Nice knots assistance in comminuted and displaced clavicle fractures reduce intraoperative blood and shorten operation time with a satisfactory postoperative clinical outcome Open
Background This study aims to evaluate the efficacy and clinical outcomes of Nice knot-assisted fixation in the management of comminuted and displaced clavicle fractures. Methods A systematic search was conducted across multiple electronic…
View article: Is anterior transposition of the ulnar nerve necessary for post-traumatic elbow stiffness? A retrospective study
Is anterior transposition of the ulnar nerve necessary for post-traumatic elbow stiffness? A retrospective study Open
View article: Surgical management of multiple damages of superior shoulder suspensory complex disruptions with coracoid fracture
Surgical management of multiple damages of superior shoulder suspensory complex disruptions with coracoid fracture Open
Background Multiple damages of the superior shoulder suspensory complex (SSSC) with coracoid fracture are exceedingly rare. Two or more site injuries of the SSSC frequently leads to delayed union, non-union and suffered motor dysfunction. …
View article: Salvage of Iatrogenic Sciatic Nerve Injury Caused by Operatively Treated Acetabular Fractures: Two Cases and Literature Review
Salvage of Iatrogenic Sciatic Nerve Injury Caused by Operatively Treated Acetabular Fractures: Two Cases and Literature Review Open
Background While sciatic nerve injury has been described as a complication of acetabular fractures, iatrogenic nerve injury remains sparsely reported. This study aims to assess iatrogenic sciatic nerve injuries occurring during acetabular …
View article: Three-dimensional sonography has satisfied accuracy for detecting rotator cuff tears
Three-dimensional sonography has satisfied accuracy for detecting rotator cuff tears Open
Background Rotator cuff injuries and tears are common causes of shoulder pain and dysfunction, necessitating accurate diagnostic methods to guide clinical decision-making. This study evaluates the diagnostic utility of three-dimensional (3…
View article: The Function and Mechanism of Anti-Inflammatory Factor Metrnl Prevents the Progression of Inflammatory-Mediated Pathological Bone Osteolytic Diseases
The Function and Mechanism of Anti-Inflammatory Factor Metrnl Prevents the Progression of Inflammatory-Mediated Pathological Bone Osteolytic Diseases Open
Metrnl, recently identified as an adipokine, is a secreted protein notably expressed in white adipose tissue, barrier tissues, and activated macrophages. This adipokine plays a pivotal role in counteracting obesity-induced insulin resistan…
View article: A unilateral external fixator combined with bone transport and tibio-talar fusion for the treatment of severe postoperative infection of peri-ankle fractures: retrospective analysis of 32 cases
A unilateral external fixator combined with bone transport and tibio-talar fusion for the treatment of severe postoperative infection of peri-ankle fractures: retrospective analysis of 32 cases Open
View article: 3D-printed PCL@BG scaffold integrated with SDF-1α-loaded hydrogel for enhancing local treatment of bone defects
3D-printed PCL@BG scaffold integrated with SDF-1α-loaded hydrogel for enhancing local treatment of bone defects Open
Background The long-term nonunion of bone defects is always a difficult problem in orthopaedics treatment. Artificial bone implants made of polymeric materials are expected to solve this problem due to their suitable degradation rate and g…
View article: The development of an ingestible biosensor for the characterization of gut metabolites related to major depressive disorder: hypothesis and theory
The development of an ingestible biosensor for the characterization of gut metabolites related to major depressive disorder: hypothesis and theory Open
The diagnostic process for psychiatric conditions is guided by the Diagnostic and Statistical Manual of Mental Disorders (DSM) in North America. Revisions of the DSM over the years have led to lowered diagnostic thresholds across the board…
View article: A unilateral external fixator combined with bone transport and tibia-talar fusion for the treatment of severe postoperative infection of peri-ankle fractures
A unilateral external fixator combined with bone transport and tibia-talar fusion for the treatment of severe postoperative infection of peri-ankle fractures Open
Background To investigate the clinical effects of a unilateral external fixator combined with bone transport and tibial-talar fusion in the treatment of severe postoperative infection of peri-ankle fractures. Methods The clinical data of 3…
View article: Femoral Neck System versus Three Cannulated Screws for Fixation of Femoral Neck Fractures in Younger Patients: A Retrospective Cohort Study
Femoral Neck System versus Three Cannulated Screws for Fixation of Femoral Neck Fractures in Younger Patients: A Retrospective Cohort Study Open
The FNS and CCS get similar hip functions. The FNS can reduce fluoroscopy exposure and the complications such as femoral neck shortening and nail withdrawal. Thus, FNS can be an alternative to CCS for the fixation of femoral neck fractures…
View article: Study of anatomical parameters and intraoperative fluoroscopic techniques for transiliac crest anterograde lag screws fixation of the posterior column of the acetabulum
Study of anatomical parameters and intraoperative fluoroscopic techniques for transiliac crest anterograde lag screws fixation of the posterior column of the acetabulum Open
Background Currently, there is a lack of research investigating the feasibility of employing anterograde lag screw fixation through the iliac crest for minimally invasive percutaneous treatment of the posterior acetabular column, which enc…
View article: A modified wire tension band technique for treatment of comminuted displaced patellar fractures
A modified wire tension band technique for treatment of comminuted displaced patellar fractures Open
Purpose: Wire tension band technique, as a widely accepted strategy for the treatment of patellar fractures, is undergoing constant improvement. This study aims to assess the clinical effect of a modified wire tension band technique for tr…
View article: Fracture Types Influence the Likelihood of Lower Urinary Tract Injuries in Patients with Pelvic Fractures
Fracture Types Influence the Likelihood of Lower Urinary Tract Injuries in Patients with Pelvic Fractures Open
Background: The combination of pelvic fractures with lower urinary tract injuries (LUTIs) is a severe traumatic injury. This study was performed to determine the relationship between LUTIs and pelvic fracture types. Methods: Patients who s…
View article: Osteoimmune Interactions and Therapeutic Potential of Macrophage-Derived Small Extracellular Vesicles in Bone-Related Diseases
Osteoimmune Interactions and Therapeutic Potential of Macrophage-Derived Small Extracellular Vesicles in Bone-Related Diseases Open
Due to the aging of the global population, the burden of bone-related diseases has increased sharply. Macrophage, as indispensable components of both innate immune responses and adaptive immunity, plays a considerable role in maintaining b…
View article: Polarization Behavior of Bone Macrophage as Well as Associated Osteoimmunity in Glucocorticoid-Induced Osteonecrosis of the Femoral Head
Polarization Behavior of Bone Macrophage as Well as Associated Osteoimmunity in Glucocorticoid-Induced Osteonecrosis of the Femoral Head Open
Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a disabling disease with high mortality in China but the detailed molecular and cellular mechanisms remain to be investigated. Macrophages are considered the key cells in…
View article: Incidence of traumatic sciatic nerve injury in patients with acetabular fractures and factors affecting recovery: a retrospective study
Incidence of traumatic sciatic nerve injury in patients with acetabular fractures and factors affecting recovery: a retrospective study Open
View article: Application of Preoperative Ultrasonography in the Percutaneous Minimally Invasive Repair of Acute Closed Achilles Tendon Rupture
Application of Preoperative Ultrasonography in the Percutaneous Minimally Invasive Repair of Acute Closed Achilles Tendon Rupture Open
Percutaneous minimally invasive surgery involving Achilles tendon (AT) repair has the advantages of a low rerupture rate and fewer postoperative complications. However, due to the inability to operate under direct vision, the injury of the…
View article: Role of Single Nucleotide Polymorphism‐Related Genes in Tumour Immune Cell Infiltration and Prognosis of Cutaneous Melanoma
Role of Single Nucleotide Polymorphism‐Related Genes in Tumour Immune Cell Infiltration and Prognosis of Cutaneous Melanoma Open
Background . Advances in cancer research have allowed for early diagnosis and improved treatment of cutaneous melanoma (CM). However, its invasiveness and recurrent metastasis, along with rising resistance to newer therapies, have lent urg…
View article: Biomechanical tests and finite element analyses of pelvic stability using bilateral single iliac screws with different channels in lumbo-iliac fixation
Biomechanical tests and finite element analyses of pelvic stability using bilateral single iliac screws with different channels in lumbo-iliac fixation Open
Background In lumbo-iliac fixation, the iliac screw can be placed in several locations and directions. There is no uniform standard for the placement of a single iliac screw. Biomechanical tests and finite element analyses were used to com…
View article: Comparative Study Between the Mini-Open (≤2.5 Cm) Approach and Conventional Open Lateral Approach in the Surgical Treatment of Radial Head Fractures
Comparative Study Between the Mini-Open (≤2.5 Cm) Approach and Conventional Open Lateral Approach in the Surgical Treatment of Radial Head Fractures Open
The mini-open approach reduced intraoperative blood loss, shortened operation time, relieved patient pain, and achieved a satisfactory postoperative clinical result, which demonstrates that the novel approach is a safe and effective option…