Ju‐Hyun Lee
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View article: The Effect of Work-Life Balance of Hair Care Workers on Job Stress and Job Satisfaction
The Effect of Work-Life Balance of Hair Care Workers on Job Stress and Job Satisfaction Open
This study empirically analyzed the relationship between work-life balance (WLB), job stress, and job satisfaction for hair care workers to understand the structural correlation between these variables. As a result of the analysis, ‘work-f…
View article: Inhibition of Sphingosine-1-Phosphate Receptor 2 (S1P<sub>2</sub>) Attenuates Imiquimod-Induced Psoriasis-Like Skin Inflammation in BALB/c Mice
Inhibition of Sphingosine-1-Phosphate Receptor 2 (S1P<sub>2</sub>) Attenuates Imiquimod-Induced Psoriasis-Like Skin Inflammation in BALB/c Mice Open
Serum and epidermal levels of sphingosine 1-phosphate (S1P) are higher in patients with psoriasis than healthy subjects. Although roles of type 1 S1P receptor, S1P1, in the development of psoriasis has intensively been investigated, roles …
View article: Blocking the Sphingosine-1-Phosphate Receptor 2 (S1P2) Reduces the Severity of Collagen-Induced Arthritis in DBA-1J Mice
Blocking the Sphingosine-1-Phosphate Receptor 2 (S1P2) Reduces the Severity of Collagen-Induced Arthritis in DBA-1J Mice Open
The amount of sphingosine 1-phosphate (S1P) found in the synovial tissue of individuals with rheumatoid arthritis is five times greater than that in those with osteoarthritis. Our study aims to determine whether inhibiting S1P2 can mitigat…
View article: Pharmacological reacidification of lysosomes attenuates intraneuronal amyloidosis, early neuron death, and amyloid plaque formation in 5xFAD mice
Pharmacological reacidification of lysosomes attenuates intraneuronal amyloidosis, early neuron death, and amyloid plaque formation in 5xFAD mice Open
Background Autophagy‐lysosomal pathway (ALP) dysfunction emerges early in Alzheimer’s disease(AD). In mouse AD models, lysosomal acidification deficits impair ALP in neurons, in some inducing massive autolysosome accumulations, intraneuron…
View article: Autophagy-lysosomal dysfunction, intraneuronal amyloidosis, and selective neuron death yield senile plaques in preclinical late-onset Alzheimer’s Disease
Autophagy-lysosomal dysfunction, intraneuronal amyloidosis, and selective neuron death yield senile plaques in preclinical late-onset Alzheimer’s Disease Open
The autophagy-lysosomal pathway (ALP) is dysfunctional in Alzheimer’s Disease (AD) although pathogenic consequences remain unclear. Here, we identify exceptionally early ALP dysfunction in neocortical neurons of late-onset sporadic AD (LOA…
View article: Free Fatty Acid 4 Receptor Activation Attenuates Collagen-Induced Arthritis by Rebalancing Th1/Th17 and Treg Cells
Free Fatty Acid 4 Receptor Activation Attenuates Collagen-Induced Arthritis by Rebalancing Th1/Th17 and Treg Cells Open
Dietary supplementation with n-3 polyunsaturated fatty acids (PUFA) has been found to be beneficial in rodent rheumatoid arthritis models and human trials. However, the molecular targets of n-3 PUFAs and their beneficial effects on rheumat…
View article: Magnolol Reduces Atopic Dermatitis-like Symptoms in BALB/c Mice
Magnolol Reduces Atopic Dermatitis-like Symptoms in BALB/c Mice Open
In traditional Korean medicines, Magnolia officinalis is commonly included for the remedy of atopic dermatitis, and magnolol is a major constituent of Magnolia officinalis. Its pharmacological effects include anti-inflammatory, hepatoprote…
View article: A Study on the Optimization of Air-Cooled Flow Channels Shpae for Cooling of Antenna Array-Type High-Power Module
A Study on the Optimization of Air-Cooled Flow Channels Shpae for Cooling of Antenna Array-Type High-Power Module Open
최근 전자 기술의 발전으로 방위산업을 비롯한 다양한 산업 분야에서 고출력 소형 전자 부품이 널리 적용되고 있으며, 이로 인한 다양한 열적 문제에 직면하고 있다. 본 연구는 균일한 간격으로 배열된 안테나의 고발열, 고열유속 부품의 냉각을 위한 공랭식 유로 형상에 대한 최적화에 대하여 수행하였다. 다양한 냉각 핀 유형, 단면 및 길이와 관련된 기하학적 매개변수에 따른 열 성능 영향에 대한 연구로서 이전에 제시된 연구보다 더 많은…
View article: Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr <sup>682</sup> -phosphorylated APP βCTF
Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr <sup>682</sup> -phosphorylated APP βCTF Open
Lysosome dysfunction arises early and propels Alzheimer’s disease (AD). Herein, we show that amyloid precursor protein (APP), linked to early-onset AD in Down syndrome (DS), acts directly via its β-C-terminal fragment (βCTF) to disrupt lys…
View article: Incidence and risk factors of skeletal-related events in patients with multiple myeloma: A population-based study of Korea
Incidence and risk factors of skeletal-related events in patients with multiple myeloma: A population-based study of Korea Open
Multiple myeloma (MM) patients are at risk of skeletal-related events (SREs) like spinal cord compression, pathologic fractures, bone surgery, and radiation to bone. Given the lack of real-world data on SREs in MM, we conducted a large, re…
View article: NJK14047 Suppression of the p38 MAPK Ameliorates OVA-Induced Allergic Asthma during Sensitization and Challenge Periods
NJK14047 Suppression of the p38 MAPK Ameliorates OVA-Induced Allergic Asthma during Sensitization and Challenge Periods Open
p38 MAPK has been implicated in the pathogenesis of asthma as well as pro-allergic Th2 cytokines, orosomucoid-like protein isoform 3 (ORMDL3), regulation of sphingolipid biosynthesis, and regulatory T cell-derived IL-35. To elucidate the r…
View article: Autophagy is a novel pathway for neurofilament protein degradation <i>in vivo</i>
Autophagy is a novel pathway for neurofilament protein degradation <i>in vivo</i> Open
How macroautophagy/autophagy influences neurofilament (NF) proteins in neurons, a frequent target in neurodegenerative diseases and injury, is not known. NFs in axons have exceptionally long half-lives in vivo enabling formation of large s…
View article: Autolysosomal acidification failure as a primary driver of Alzheimer disease pathogenesis
Autolysosomal acidification failure as a primary driver of Alzheimer disease pathogenesis Open
Genetic evidence has increasingly linked lysosome dysfunction to an impaired autophagy-lysosomal pathway (ALP) flux in Alzheimer disease (AD) although the relationship of these abnormalities to other pathologies is unclear. In our recent i…
View article: Investigation of Patient-Centric 3D-Printed Orodispersible Films Containing Amorphous Aripiprazole
Investigation of Patient-Centric 3D-Printed Orodispersible Films Containing Amorphous Aripiprazole Open
The objective of this study was to design and evaluate an orodispersible film (ODF) composed of aripiprazole (ARP), prepared using a conventional solvent casting technique, and to fuse a three-dimensional (3D) printing technique with a hot…
View article: p38 MAPK Inhibitor NJK14047 Suppresses CDNB-Induced Atopic Dermatitis-Like Symptoms in BALB/c Mice
p38 MAPK Inhibitor NJK14047 Suppresses CDNB-Induced Atopic Dermatitis-Like Symptoms in BALB/c Mice Open
Atopic dermatitis (AD) is a chronic inflammatory skin disorder. Suppression of MAPKs and NF-κB is implicated as a vital mechanism of action of several traditional Chinese medicines for AD therapy. Although overexpression of MAPK mRNA in th…
View article: Lysosomal dysfunction in Down Syndrome and Alzheimer mouse models is caused by selective v-ATPase inhibition by Tyr<sup>682</sup>phosphorylated APP βCTF
Lysosomal dysfunction in Down Syndrome and Alzheimer mouse models is caused by selective v-ATPase inhibition by Tyr<sup>682</sup>phosphorylated APP βCTF Open
Lysosome dysfunction arises early and propels Alzheimer’s Disease (AD). Herein, we show that amyloid precursor protein (APP), linked to early-onset AD in Down Syndrome (DS), acts directly via its β-C-terminal fragment (βCTF) to disrupt lys…
View article: Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques
Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques Open
Autophagy is markedly impaired in Alzheimer’s disease (AD). Here we reveal unique autophagy dysregulation within neurons in five AD mouse models in vivo and identify its basis using a neuron-specific transgenic mRFP-eGFP-LC3 probe of autop…
View article: Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca <sup>2+</sup> efflux and disrupted by PSEN1 loss of function
Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca <sup>2+</sup> efflux and disrupted by PSEN1 loss of function Open
Dysfunction and mistrafficking of organelles in autophagy- and endosomal-lysosomal pathways are implicated in neurodegenerative diseases. Here, we reveal selective vulnerability of maturing degradative organelles (late endosomes/amphisomes…
View article: Improved Bioavailability of Poorly Water-Soluble Drug by Targeting Increased Absorption through Solubility Enhancement and Precipitation Inhibition
Improved Bioavailability of Poorly Water-Soluble Drug by Targeting Increased Absorption through Solubility Enhancement and Precipitation Inhibition Open
Itraconazole (ITZ) is a class II drug according to the biopharmaceutical classification system. Its solubility is pH 3-dependent, and it is poorly water-soluble. Its pKa is 3.7, which makes it a weak base drug. The aim of this study was to…
View article: Salvianolic Acid A Suppresses DNCB-Induced Atopic Dermatitis-Like Symptoms in BALB/c Mice
Salvianolic Acid A Suppresses DNCB-Induced Atopic Dermatitis-Like Symptoms in BALB/c Mice Open
Prevalence of atopic dermatitis (AD), a chronic, pruritic, and relapsing inflammatory skin disorder, is growing. Because available therapeutics is limited, immune regulators from natural resources could be helpful for treating AD symptoms.…
View article: 4-CMTB Ameliorates Ovalbumin-Induced Allergic Asthma through FFA2 Activation in Mice
4-CMTB Ameliorates Ovalbumin-Induced Allergic Asthma through FFA2 Activation in Mice Open
Free fatty acid receptor 2 (FFA2, also known as GPR43), a G-protein-coupled receptor, has been known to recognize short-chain fatty acids and regulate inflammatory responses. FFA2 gene deficiency exacerbated disease states in several model…
View article: A Case Report of Atopic Dermatitis with Otitis Media with Effusion and Chronic Rhinitis
A Case Report of Atopic Dermatitis with Otitis Media with Effusion and Chronic Rhinitis Open
Objectives This study aims to report a case of atopic dermatitis with otitis media with effusion and chronic rhinitis improved by oral administration of Galgeungabanha-tang. Methods The patient of this case had symptoms such as erythema, a…
View article: A Case Report of Hot Flush-Type Rosacea Improved by Baekho-tang
A Case Report of Hot Flush-Type Rosacea Improved by Baekho-tang Open
Objectives This study aims to report a case of hot flush-type rosacea improved by oral administration of Baekho-tang. Methods The patient visited our clinic due to hot flash symptom on April 16, 2020. Based on the symptoms of hating heat, …
View article: Tumor LAG-3 and NY-ESO-1 expression predict durable clinical benefits of immune checkpoint inhibitors in advanced non-small cell lung cancer
Tumor LAG-3 and NY-ESO-1 expression predict durable clinical benefits of immune checkpoint inhibitors in advanced non-small cell lung cancer Open
Background Immune checkpoint inhibitors (ICIs) are an established treatment for non-small cell lung cancer (NSCLC) that have demonstrated durable clinical benefits (DCBs). Previous studies have suggested that NY-ESO-1 and LAG-3 could be su…
View article: Topical Application of S1P<sub>2</sub> Antagonist JTE-013 Attenuates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice
Topical Application of S1P<sub>2</sub> Antagonist JTE-013 Attenuates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice Open
Sphingosine-1-phosphate (S1P) and its receptors have been implicated in atopic dermatitis. S1P2 was found to function as a proallergic receptor, while its antagonist JTE-013 was found to suppress allergic asthma in mice. Topical applicatio…
View article: Fabrication of Intragastric Floating, Controlled Release 3D Printed Theophylline Tablets Using Hot-Melt Extrusion and Fused Deposition Modeling
Fabrication of Intragastric Floating, Controlled Release 3D Printed Theophylline Tablets Using Hot-Melt Extrusion and Fused Deposition Modeling Open
This work presents a novel approach for producing gastro-retentive floating tablets (GRFT) by coupling hot-melt extrusion (HME) and fused deposition three-dimensional printing (3DP). Filaments containing theophylline (THEO) within a hydrox…