Farah Oulaïdi
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View article: Isofagomine inhibits multiple TcdB variants and protects mice from<i>Clostridioides difficile</i>induced mortality
Isofagomine inhibits multiple TcdB variants and protects mice from<i>Clostridioides difficile</i>induced mortality Open
Clostridioides difficile causes life-threatening diarrhea and is the leading cause of healthcare associated bacterial infections in the United States. During infection, C. difficile releases the gut-damaging toxins, TcdA and TcdB, the prim…
View article: Synthesis and Characterization of Transition-State Analogue Inhibitors against Human DNA Methyltransferase 1
Synthesis and Characterization of Transition-State Analogue Inhibitors against Human DNA Methyltransferase 1 Open
Hypermethylation of CpG regions by human DNA methyltransferase 1 (DNMT1) silences tumor-suppression genes, and inhibition of DNMT1 can reactivate silenced genes. The 5-azacytidines are approved inhibitors of DNMT1, but their mutagenic mech…