Faraz Pathan
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View article: Platelet derived growth factor-AB modulates post-infarct myocardium leading to extended improvement in cardiac function
Platelet derived growth factor-AB modulates post-infarct myocardium leading to extended improvement in cardiac function Open
Myocardial infarction (MI) contributes to significant morbidity and mortality globally. Platelet derived growth factor-AB (PDGF-AB) is potentially a novel translational therapeutic for improving cardiac function post-MI, which we assess he…
View article: The Effect of Body Size and Obesity on Cardiovascular Haemodynamics and Myocardial Mechanics
The Effect of Body Size and Obesity on Cardiovascular Haemodynamics and Myocardial Mechanics Open
Obesity is associated with increased CO; this increase is a result of cardiac remodelling and consequent increase in stroke volume. Obesity is associated with an impairment of subclinical markers of cardiovascular disease measured using mu…
View article: Evaluating the Orbit Wearable Headband for Ecologically Valid Mental State Assessment: EEG/PPG Signal Quality and Efficacy in Multimodal Data Analysis
Evaluating the Orbit Wearable Headband for Ecologically Valid Mental State Assessment: EEG/PPG Signal Quality and Efficacy in Multimodal Data Analysis Open
Consumer wearables for mental state assessment face scepticism regarding data quality. This study evaluated whether a consumer-grade EEG/PPG headband (Orbit) can reliably capture mental states in real-world settings. We compared Orbit's EE…
View article: Left atrial strain tracks abnormal ventricular mechanics in Fabry disease
Left atrial strain tracks abnormal ventricular mechanics in Fabry disease Open
Background Fabry disease (FD) is an X linked lysosomal disorder with ventricular myocardial involvement that drives morbidity and mortality. Early diagnosis of cardiac involvement can be difficult. This study explored whether abnormal left…
View article: Fulminant Myocarditis With Normal Inflammatory Markers
Fulminant Myocarditis With Normal Inflammatory Markers Open
This case underscores the importance of multimodality imaging for rapid decision-making in diagnosing myocarditis, particularly when clinical suspicion is high despite initial nonspecific biochemical tests and echocardiography.
View article: Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease
Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease Open
Importance Coronary artery calcium (CAC) scoring provides prognostic information, especially in patients at intermediate risk for coronary artery disease (CAD). However, the benefit of combining CAC score with a primary prevention strategy…
View article: Left atrial strain tracks abnormal ventricular mechanics in Fabry disease
Left atrial strain tracks abnormal ventricular mechanics in Fabry disease Open
Backgrounds Fabry disease (FD) is an X-linked lysosomal disorder with ventricular myocardial involvement that drives morbidity and mortality. Early diagnosis of cardiac involvement can be difficult. This study explored whether abnormal lef…
View article: Non-malignant gynaecological disease and risk of cardiovascular or cerebrovascular disease: a systematic review and meta-analysis
Non-malignant gynaecological disease and risk of cardiovascular or cerebrovascular disease: a systematic review and meta-analysis Open
Background Cardiovascular disease is the leading cause of death globally. Non-malignant gynaecological diseases (NMGD) significantly affect patient health and well-being and may be associated with cardiovascular or cerebrovascular disease …
View article: Impact of maternal diabetes mellitus on fetal atrial strain
Impact of maternal diabetes mellitus on fetal atrial strain Open
While Maternal Diabetes Mellitus (DM) is well known to affect the size and function of multiple fetal organ systems, effects on developing heart chamber function remain difficult to assess. We sought to determine the independent impact of …
View article: Restoring microvascular circulation with diagnostic ultrasound and contrast agent: rationale and design of the REDUCE trial
Restoring microvascular circulation with diagnostic ultrasound and contrast agent: rationale and design of the REDUCE trial Open
This multicentre trial will test whether sonothrombolysis delivered pre and post primary PCI can improve patient outcomes and is cost-effective, when compared with sham ultrasound delivered with primary PCI. The results from this trial may…
View article: Correlation of Noninvasive Cardiac MRI Measures of Left Ventricular Myocardial Function and Invasive Pressure-Volume Parameters in a Porcine Ischemia-Reperfusion Model
Correlation of Noninvasive Cardiac MRI Measures of Left Ventricular Myocardial Function and Invasive Pressure-Volume Parameters in a Porcine Ischemia-Reperfusion Model Open
Purpose To assess the correlation between noninvasive cardiac MRI-derived parameters with pressure-volume (PV) loop data and evaluate changes in left ventricular function after myocardial infarction (MI). Materials and Methods Sixteen adul…
View article: Prophylaxis to Prevent Cardiotoxicity in Patients Receiving Anthracycline for Breast Cancer: A Combined Bayesian and Frequentist Network Meta-Analysis of Randomised Controlled Trials
Prophylaxis to Prevent Cardiotoxicity in Patients Receiving Anthracycline for Breast Cancer: A Combined Bayesian and Frequentist Network Meta-Analysis of Randomised Controlled Trials Open
There is insufficient evidence to support prophylactic cardioprotection to prevent EF reduction. However, frequentist analysis suggested that AA or BBs provide cardioprotection. Thus, for those already on other anti-hypertensives, switchin…
View article: Index of Microcirculatory Resistance to predict microvascular obstruction in STEMI: A systematic review and meta‐analysis
Index of Microcirculatory Resistance to predict microvascular obstruction in STEMI: A systematic review and meta‐analysis Open
Background Microvascular obstruction (MVO) is an independent predictor of adverse cardiac events after ST‐elevation myocardial infarction (STEMI). The Index of Microcirculatory Resistance (IMR) may be a useful marker of MVO, which could si…
View article: Rationale and Design of the Cessation Of Pharmacotherapy In Recovered Chemotherapy-induced cardioToxicity (COP-RCT): A Pilot Study
Rationale and Design of the Cessation Of Pharmacotherapy In Recovered Chemotherapy-induced cardioToxicity (COP-RCT): A Pilot Study Open
Cessation Of Pharmacotherapy In Recovered Chemotherapy-induced cardioToxicity (COP-RCT) is one of the first studies currently underway to evaluate the safety of ceasing CPT in recovered CTRCD. The results will inform clinical practice in t…
View article: A review of current landscape and definition of septic cardiomyopathy
A review of current landscape and definition of septic cardiomyopathy Open
Background Septic cardiomyopathy (SCM) is a reversible myocardial dysfunction that is increasingly recognised in critically-ill septic patients. SCM and sepsis cause significant morbidity and mortality. However, the lack of consensus on th…
View article: Sonothrombolysis delivered before percutaneous coronary intervention improves myocardial salvage in ST elevation myocardial infarction
Sonothrombolysis delivered before percutaneous coronary intervention improves myocardial salvage in ST elevation myocardial infarction Open
Background Sonothrombolysis (STL) is the application of high mechanical index ultrasound whilst infusing an ultrasound contrast agent. Prior studies have shown that STL delivered pre & post primary percutaneous coronary intervention (pPCI)…
View article: Assessing left atrial size to predict mortality in the overweight and obese population
Assessing left atrial size to predict mortality in the overweight and obese population Open
Background Left atrial (LA) size provides important prognostic information. A larger LA is associated with a higher risk of death or cardiovascular complications. LA size is generally measured by indexing LA volume to body surface area (BS…
View article: Variations in indexation of left atrial volume across different races
Variations in indexation of left atrial volume across different races Open
Despite a cohort with normal BMI, there was still disparity in LAV indexation with BSA across races. Allometric height indexation, particularly using height1.72, is a possible solution, although further validation studies in BMI extremes a…