Faraz Sultan
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View article: Stress-Responsive Transcriptomic Signatures in Human iPSC-Derived Microglia Reveal Links to Alzheimer’s Disease Risk Genes
Stress-Responsive Transcriptomic Signatures in Human iPSC-Derived Microglia Reveal Links to Alzheimer’s Disease Risk Genes Open
Cellular stress responses are essential for maintaining homeostasis in the face of environmental or internal challenges. In the central nervous system, microglia serve as key stress sensors and immune responders, shaping neuroinflammatory …
View article: Robust, scalable, and informative clustering for diverse biological networks
Robust, scalable, and informative clustering for diverse biological networks Open
Clustering molecular data into informative groups is a primary step in extracting robust conclusions from big data. However, due to foundational issues in how they are defined and detected, such clusters are not always reliable, leading to…
View article: An Improved CRISPR/dCas9 Interference Tool for Neuronal Gene Suppression
An Improved CRISPR/dCas9 Interference Tool for Neuronal Gene Suppression Open
The expression of genetic material governs brain development, differentiation, and function, and targeted manipulation of gene expression is required to understand contributions of gene function to health and disease states. Although recen…
View article: Enhancer RNAs predict enhancer–gene regulatory links and are critical for enhancer function in neuronal systems
Enhancer RNAs predict enhancer–gene regulatory links and are critical for enhancer function in neuronal systems Open
Genomic enhancer elements regulate gene expression programs important for neuronal fate and function and are implicated in brain disease states. Enhancers undergo bidirectional transcription to generate non-coding enhancer RNAs (eRNAs). Ho…
View article: A dopamine-induced gene expression signature regulates neuronal function and cocaine response
A dopamine-induced gene expression signature regulates neuronal function and cocaine response Open
Single-nucleus RNA-seq reveals a dynamic and cell-specific gene program in striatal neurons that contributes to cocaine response.
View article: An improved CRISPR/dCas9 interference tool for neuronal gene suppression
An improved CRISPR/dCas9 interference tool for neuronal gene suppression Open
The expression of genetic material governs brain development, differentiation, and function, and targeted manipulation of gene expression is required to understand contributions of gene function to health and disease states. Although recen…
View article: Regulation of dopamine-dependent transcription and cocaine action by<i>Gadd45b</i>
Regulation of dopamine-dependent transcription and cocaine action by<i>Gadd45b</i> Open
Exposure to drugs of abuse produces robust transcriptional and epigenetic reorganization within brain reward circuits that outlives the direct effects of the drug and may contribute to addiction. DNA methylation is a covalent epigenetic mo…
View article: A dopamine-induced gene expression signature regulates neuronal function and cocaine response
A dopamine-induced gene expression signature regulates neuronal function and cocaine response Open
Drug addiction is a worldwide health problem, with overdose rates of both psychostimulants and opioids currently on the rise in many developed countries. Drugs of abuse elevate dopamine levels in the nucleus accumbens (NAc) and alter trans…
View article: A Novel Dual Lentiviral CRISPR-based Transcriptional Activation System for Gene Expression Regulation in Neurons
A Novel Dual Lentiviral CRISPR-based Transcriptional Activation System for Gene Expression Regulation in Neurons Open
Robust and efficient gene expression control enables the study of a gene's function in the central nervous system. Advances in CRISPR-based technology provide new avenues not only for gene editing, but for complex transcriptional control. …
View article: A Neuron-Optimized CRISPR/dCas9 Activation System for Robust and Specific Gene Regulation
A Neuron-Optimized CRISPR/dCas9 Activation System for Robust and Specific Gene Regulation Open
CRISPR-based technology has provided new avenues to interrogate gene function, but difficulties in transgene expression in post-mitotic neurons has delayed incorporation of these tools in the central nervous system (CNS). Here, we demonstr…
View article: A neuron-optimized CRISPR/dCas9 activation system for robust and specific gene regulation
A neuron-optimized CRISPR/dCas9 activation system for robust and specific gene regulation Open
Recent developments in CRISPR-based gene editing have provided new avenues to interrogate gene function. However, application of these tools in the central nervous system has been delayed due to difficulties in transgene expression in post…
View article: Enhancer RNAs predict enhancer-gene regulatory links and are critical for enhancer function in neuronal systems
Enhancer RNAs predict enhancer-gene regulatory links and are critical for enhancer function in neuronal systems Open
Genomic enhancer elements regulate gene expression programs important for neuronal fate and function and are implicated in brain disease states. Enhancers undergo bidirectional transcription to generate non-coding enhancer RNAs (eRNAs). Ho…