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View article: Cognitive heterogeneity of data‐driven phenotypes and associations with ADRD and cerebrovascular biomarkers in the Atherosclerosis Risk in Communities Study
Cognitive heterogeneity of data‐driven phenotypes and associations with ADRD and cerebrovascular biomarkers in the Atherosclerosis Risk in Communities Study Open
Background Even among cognitively unimpaired (CU) older adults, specific patterns of neuropsychological performance impart differential risk for progression to Alzheimer's disease and related dementias (ADRD). Early identification in the p…
View article: Greater Cognitive Intraindividual Variability Predicts Faster Decline in Everyday Functioning: Moderating Effects of Amyloid Status and APOE Genotype
Greater Cognitive Intraindividual Variability Predicts Faster Decline in Everyday Functioning: Moderating Effects of Amyloid Status and APOE Genotype Open
Background Cognitive intraindividual variability (IIV), or within‐person variability across cognitive measures at a single time point, is associated with increased risk of mild cognitive impairment (MCI) and Alzheimer's disease (AD) dement…
View article: Associations of cognitive intraindividual variability and regional brain volumes vary by sex in the Baltimore Longitudinal Study of Aging
Associations of cognitive intraindividual variability and regional brain volumes vary by sex in the Baltimore Longitudinal Study of Aging Open
Background Cognitive intraindividual variability (IIV) is associated with biomarkers of neurodegeneration, long‐term cognitive functioning, and progression to mild cognitive impairment/dementia. However, the extent to which these associati…
View article: Neuropsychiatric Phenotypes in Cognitively Unimpaired Older Adults: Associations with Clinical Progression and Domain‐Specific Cognitive Trajectories
Neuropsychiatric Phenotypes in Cognitively Unimpaired Older Adults: Associations with Clinical Progression and Domain‐Specific Cognitive Trajectories Open
Background Data‐driven analyses of neuropsychological measures have identified subtle cognitive decline phenotypes that demonstrate unique associations with Alzheimer's disease risk and progression. While early detection efforts traditiona…
View article: Neuropsychiatric symptom phenotypes for early detection of risk in older adults
Neuropsychiatric symptom phenotypes for early detection of risk in older adults Open
INTRODUCTION We examined whether early neuropsychiatric symptom (NPS) patterns were associated with cognitive and neuropathologic changes. METHODS Latent class analysis within 20,599 cognitively unimpaired older adults in the National Alzh…
View article: Impact of regional white matter hyperintensity patterns on cognitive trajectories in NACC
Impact of regional white matter hyperintensity patterns on cognitive trajectories in NACC Open
INTRODUCTION White matter hyperintensities (WMHs) are a biomarker of small vessel cerebrovascular changes that can emerge early in Alzheimer's disease. While global WMHs correlate with cognitive decline, the impact of regional WMHs remains…
View article: A Neuroimaging Study of the Effort-Reward Imbalance Framework for Cognitive Fatigue in Individuals with Multiple Sclerosis
A Neuroimaging Study of the Effort-Reward Imbalance Framework for Cognitive Fatigue in Individuals with Multiple Sclerosis Open
Background: Cognitive fatigue is one of the most pervasive yet least understood symptoms in persons with multiple sclerosis (PwMS). The current study examined whether the effort-reward imbalance, a cognitive neuroscience-based framework, c…
View article: 13 Money versus Feedback: Comparing Reward Types and Frequency on Cognitive Fatigue
13 Money versus Feedback: Comparing Reward Types and Frequency on Cognitive Fatigue Open
Objective: Cognitive fatigue (CF) is a common, yet poorly understood symptom in neurological disorders (e.g., multiple sclerosis, Parkinson’s disease, stroke). Studies show that reward plays a central role in CF. For instance, introducing …
View article: Individual-level functional connectivity predicts cognitive control efficiency
Individual-level functional connectivity predicts cognitive control efficiency Open
Cognitive control (CC) is essential for problem-solving in everyday life, and CC-related deficits occur alongside costly and debilitating disorders. The tri-partite model suggests that CC comprises multiple behaviors, including switching, …
View article: A Measure of Neural Function Provides Unique Insights into Behavioral Deficits in Acute Stroke
A Measure of Neural Function Provides Unique Insights into Behavioral Deficits in Acute Stroke Open
Background: Clinical and neuroimaging measures incompletely explain behavioral deficits in the acute stroke setting. We hypothesized that electroencephalography (EEG)-based measures of neural function would significantly improve prediction…
View article: Investigating the influence of an <scp>effort–reward</scp> interaction on cognitive fatigue in individuals with multiple sclerosis
Investigating the influence of an <span>effort–reward</span> interaction on cognitive fatigue in individuals with multiple sclerosis Open
This study examined whether an alteration in the effort–reward relationship, a theoretical framework based on cognitive neuroscience, could explain cognitive fatigue. Forty persons with MS and 40 healthy age‐ and education‐matched cognitiv…
View article: Individual-level Functional Connectivity Predicts Cognitive Control Efficiency
Individual-level Functional Connectivity Predicts Cognitive Control Efficiency Open
Cognitive control (CC) is a vital component of cognition associated with problem-solving in everyday life. Many neurological and neuropsychiatric conditions have deficits associated with CC. CC is composed of multiple behaviors including s…
View article: The Relationship between Fatigue and a Clinically Accessible Measure of Switching in Individuals with Multiple Sclerosis
The Relationship between Fatigue and a Clinically Accessible Measure of Switching in Individuals with Multiple Sclerosis Open
Objective We examined whether fatigue in multiple sclerosis (MS) is linked to switching processes when switching is measured by the Trail Making Test (TMT). Method Eighty-three participants with MS were administered a battery of standardiz…
View article: Testing a Model for Cognitive Fatigue in Individuals with Multiple Sclerosis
Testing a Model for Cognitive Fatigue in Individuals with Multiple Sclerosis Open
Up to 95% of individuals with multiple sclerosis (MS) experience fatigue. The cognitive component of fatigue is generally reported as the most distressing aspect of patients' fatigue, limiting their ability to sustain concentration and end…
View article: Electroencephalography Might Improve Diagnosis of Acute Stroke and Large Vessel Occlusion
Electroencephalography Might Improve Diagnosis of Acute Stroke and Large Vessel Occlusion Open
Background and Purpose: Clinical methods have incomplete diagnostic value for early diagnosis of acute stroke and large vessel occlusion (LVO). Electroencephalography is rapidly sensitive to brain ischemia. This study examined the diagnost…
View article: Predicting Gains With Visuospatial Training After Stroke Using an EEG Measure of Frontoparietal Circuit Function
Predicting Gains With Visuospatial Training After Stroke Using an EEG Measure of Frontoparietal Circuit Function Open
The heterogeneity of stroke prompts the need for predictors of individual treatment response to rehabilitation therapies. We previously studied healthy subjects with EEG and identified a frontoparietal circuit in which activity predicted t…