Explanipedia

The impact of CYP2C9, VKORC1, and CYP4F2 polymorphisms on warfarin dose requirement in Saudi patients Open

Salha Jokhab, Maha Al‐Rasheed, Dana Bakheet, Abdulkareem Al-Momen, Nouf M. Alaboud , et al. · 2025

Background Limited data are available on factors that affect warfarin dose requirement in Saudi patients. Saudis are among the underrepresented ethnic groups in warfarin pharmacogenetics research. The present study investigated the frequen…

A randomized crossover design study comparing the pharmacokinetics and pharmacodynamics of 2 single doses of oral aspirin (75 mg v 150 mg) in pregnant women at risk of preeclampsia: implications on assessing aspirin response and patient adherence to therapy Open

Raya Vinogradov, Oisín N. Kavanagh, Jeremy Palmer, Paul V. Murphy, Elizabeth Curtis , et al. · 2024

Compared to the 75-mg dose, 150 mg of aspirin more effectively inhibits thromboxane B₂, providing rationale for further investigation of effectiveness of higher doses for preeclampsia prevention. Despite limitations, measuring s…

Determination of Dabigatran Concentration in Human Plasma and Breast Milk Open

Frances R. Sidgwick, Andrew Porter, Paul Ayuk, Farhad Kamali, Achim Truemann · 2021

Venous thromboembolism (VTE) is an important cause of death following childbirth. Dabigatran etexilate can be a useful prophylaxis in susceptible women during the postpartum period. However, it is not clear whether dabigatran is excreted i…

Assessment of exposure to direct oral anticoagulants in elderly hospitalised patients Open

Emmanouela Kampouraki, Peter Avery, Tina Biss, Hilary Wynne, Farhad Kamali · 2021

Summary It is unclear whether elderly patients established on direct oral anticoagulants (DOACs) have greater exposure to these drugs, which could subsequently increase their risk of bleeding. We assessed DOAC exposure and factors affectin…

Elderly people are inherently sensitive to the pharmacological activity of rivaroxaban: implications for DOAC prescribing Open

Emmanouela Kampouraki, Salah Abohelaika, Peter Avery, Tina Biss, Paul Murphy , et al. · 2020

According to both trial and clinical data on direct oral anticoagulants (DOACs) elderly patients are at greatest risk of bleeding. It is unclear whether age intrinsically affects anticoagulation response. To investigate the age-related sen…

Validation of an algorithm to predict decline in INR following warfarin cessation in patients undergoing invasive procedures Open

Emmanouela Kampouraki, Hilary Wynne, Peter Avery, Farhad Kamali · 2019

Investigation of dabigatran secretion into breast milk: Implications for oral thromboprophylaxis in post‐partum women Open

Paul Ayuk, Emmanouela Kampouraki, Achim Truemann, Frances R. Sidgwick, Lynne McDonald , et al. · 2019

Pregnancy and the post-partum period are recognized risk factors for venous thrombo-embolism (VTE), one of the most important causes of maternal mortality.1 Sub-cutaneous low molecular weight heparin (LMWH) is the current recommendation fo…

Elderly People are More Sensitive to the Pharmacological Activity of Rivaroxaban: Implications for DOAC Prescribing Open

Emmanouela Kampouraki, Salah Abohelaika, Peter Avery, Tina Biss, Paul Murphy , et al. · 2019

Alcohol and other substance use among medical and law students at a UK university: a cross-sectional questionnaire survey Open

Paul Bogowicz, Jennifer Ferguson, Éilish Gilvarry, Farhad Kamali, Eileen Kaner , et al. · 2017

Purpose of the study To examine the use of alcohol and other substances among medical and law students at a UK university. Study design Anonymous cross-sectional questionnaire survey of first, second and final year medical and law students…

IAU volume 13 issue S336 Cover and Front matter Open

C Bergman, B. Stecklum, A. Caratti o Garatti, K. W. Hodapp, H. Linz , et al. · 2017

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Assessment of the efficacy of a novel tailored vitamin K dosing regimen in lowering the International Normalised Ratio in over‐anticoagulated patients: a randomised clinical trial Open

Emmanouela Kampouraki, Peter Avery, Hilary Wynne, Tina Biss, John Hanley , et al. · 2017

Summary Current guidelines advocate using fixed‐doses of oral vitamin K to reverse excessive anticoagulation in warfarinised patients who are either asymptomatic or have minor bleeds. Over‐anticoagulated patients present with a wide range …

Warfarin Dose Model for the Prediction of Stable Maintenance Dose in Indian Patients Open

Tejasvita Gaikwad, Kanjaksha Ghosh, Peter Avery, Farhad Kamali, Shrimati Shetty · 2017

The main aim of this study was to screen various genetic and nongenetic factors that are known to alter warfarin response and to generate a model to predict stable warfarin maintenance dose for Indian patients. The study comprised of 300 w…

Age‐stratified outcome of a genotype‐guided dosing algorithm for acenocoumarol and phenprocoumon Open

Yumao Zhang, Anthonius de Boer, Talitha I. Verhoef, F.J.M. van der Meer, Saskia le Cessie , et al. · 2016

Impact of age on long‐term anticoagulation and how gender and monitoring setting affect it: implications for decision making and patient management Open

Salah Abohelaika, Hilary Wynne, Peter Avery, Brian Robinson, Patrick Kesteven , et al. · 2016

Aims Stabilization of anticoagulation control is seminal to reducing the risk of adverse effects of vitamin K antagonists. Reliable information on how ageing influences this is lacking. We set out to assess the true age‐related changes in …

A multi-factorial analysis of response to warfarin in a UK prospective cohort Open

Stéphane Bourgeois, Andrea Jorgensen, Eunice J. Zhang, Anita Hanson, Matthew Gillman , et al. · 2016

Additional file 1: Sheet 1. of A multi-factorial analysis of response to warfarin in a UK prospective cohort Open

Stéphane Bourgeois, Andrea Jorgensen, Eunice Zhang, Anita Hanson, Matthew W. Gillman , et al. · 2016

Interaction coefficients of drugs known to be interacting with warfarin. Drugs known to interact with warfarin were classified according to their effect on warfarin dosing, with a plus sign for potentiating drugs, and minus for the opposit…

VKORC1 (-1639) Polymorphisms do not Affect Long-Term Stability of Anticoagulation with Warfarin Open

Salah Abohelaika, Farhad Kamali, Hilary Wynne · 2015

The extent of INR fall following vitamin K supplementation to patients on warfarin is related to VKORC1-1639G>A genotype, with those carrying the GG genotype demonstrating a significantly larger fall in INR compared to those carrying the G…

Quality of life in patients with venous thromboembolism and atrial fibrillation treated with coumarin anticoagulants Open

Camilla L. Marvig, Talitha I. Verhoef, Anthonius de Boer, Farhad Kamali, Ken Redekop , et al. · 2015

The impact of genetics on the management of patients on warfarin awaiting surgery Open

Salah Abohelaika, Hilary Wynne, L. Cope, Farhad Kamali · 2015

Two older patients with atrial fibrillation, receiving warfarin for thromboembolic prophylaxis, with a target range of 2.0-3.0, were significantly over anticoagulated prior to elective intervention, in spite of having adhered to the standa…

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