Muhammad Ikram Ullah
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View article: MicroRNA-125b-5p Drives MMP-2 Expression via Activation of RAGE-38MAPK-p65/p50NF-κB Axis: A Novel Mechanism in Human Lung Cancer Cells
MicroRNA-125b-5p Drives MMP-2 Expression via Activation of RAGE-38MAPK-p65/p50NF-κB Axis: A Novel Mechanism in Human Lung Cancer Cells Open
Dysregulated microRNA-mediated control of matrix metalloproteinase-2 (MMP-2) plays a pivotal role in lung cancer (LC) progression, though the inflammatory signaling mechanisms governing its regulation remain poorly understood. This study r…
View article: Association of serum copper, zinc and copper to zinc ratio in patients with acute myeloid leukemia
Association of serum copper, zinc and copper to zinc ratio in patients with acute myeloid leukemia Open
Acute myeloid leukemia (AML) is a rare hematological disorder that has detrimental effects on human health and requires the exploration of biomarkers for diagnosis and prognostic evaluation. Essential trace elements like copper (Cu) and zi…
View article: Citronellol silver nanoconjugates as a therapeutic strategy for glioblastoma through computational and experimental evaluation
Citronellol silver nanoconjugates as a therapeutic strategy for glioblastoma through computational and experimental evaluation Open
Glioblastoma is the most prevalent type of brain tumor, and because of drug resistance, treatment for gliomas has been less successful. Citronellol is an acyclic monoterpene alcohol with various pharmacological properties. This study aimed…
View article: Computational identification and evaluation of novel PD-L1 inhibitors for cancer immunotherapy
Computational identification and evaluation of novel PD-L1 inhibitors for cancer immunotherapy Open
Antibody-based therapies targeting the PD-1/PD-L1 pathway have shown promise in anticancer immunotherapy; however, challenges such as high cost, immunogenicity, and limited penetration highlight the need for small-molecule inhibitors. To f…
View article: Reviewing Methods and Means of Suicide Attempt: Lethality verses non-lethality
Reviewing Methods and Means of Suicide Attempt: Lethality verses non-lethality Open
In suicide related studies methods and means of suicide attempt are one of the key debates (Lester, 2008). There are social, cultural, and psychological explanations to why an individual chooses a particular method for attempting a suicide…
View article: Novel ATOH7 mutation and structural characterization in families with optic nerve hypoplasia
Novel ATOH7 mutation and structural characterization in families with optic nerve hypoplasia Open
AIM: To detect and segregate causative mutations in congenital families with optic nerve hypoplasia (ONH). METHODS: Two unrelated consanguineous Pakistani families with severe ONH, showing features of micropthalmia, nystagmus, corneal opac…
View article: Role of metabolomic changes in diagnosis and assessment of treatment response in acute myeloid leukemia
Role of metabolomic changes in diagnosis and assessment of treatment response in acute myeloid leukemia Open
Acute Myeloid Leukemia (AML) is an aggressive cancer characterized by the rapid proliferation of abnormal myeloid cells. Despite advancements in treatment, patient outcomes remain variable, underscoring the need for more accurate diagnosti…
View article: Identification and evaluation of pyrimidine based CDK6 inhibitors against glioblastoma using integrated computational approaches
Identification and evaluation of pyrimidine based CDK6 inhibitors against glioblastoma using integrated computational approaches Open
Cyclin-dependent kinases (CDKs) are crucial for controlling the cell cycle, and many malignancies are linked to CDK dysfunction. Therefore, CDKs are desirable targets for cancer treatment. Since abnormal expression of CDK4/6 is the etiolog…
View article: Fucoidan From Brown Algae as a Functional Food Ingredient: A Promising Anticancer Agent
Fucoidan From Brown Algae as a Functional Food Ingredient: A Promising Anticancer Agent Open
Fucoidan is a naturally occurring, sulfated fucose‐based polymer found in many types of brown algae. Fucoidan has recently attracted interest in the field of oncology due to its biological and pharmacological features, such as antitumor, a…
View article: Multiscale computational evaluation of Vitex trifolia phytochemicals as VEGFR2 inhibitors for targeted breast cancer therapy
Multiscale computational evaluation of Vitex trifolia phytochemicals as VEGFR2 inhibitors for targeted breast cancer therapy Open
Breast cancer (BC), the second most common cancer, is a genetically heterogeneous disease driven by angiogenesis, cell growth, metastasis, and oxidative stress. VEGFR2, a key angiogenesis regulator, presents a potential target for inhibiti…
View article: Comparative Study of Ti3C2Tx MXene Synthesized via HF and LiF-HCl Etching: Structural, Optical, and Photocatalytic Insights
Comparative Study of Ti3C2Tx MXene Synthesized via HF and LiF-HCl Etching: Structural, Optical, and Photocatalytic Insights Open
Two-dimensional MXene (Ti 3 C 2 T x ) was successfully synthesized from the Ti 3 AlC 2 MAX phase using two different etching elements such as hydrofluoric acid (HF) and an amalgamation of lithium fluoride (LiF) with hydrochloric acid (HCl)…
View article: The Impact of Despotic Leadership on Knowledge Sharing Behavior with the Mediating Role of Job Satisfaction: Application of Social Exchange Theory
The Impact of Despotic Leadership on Knowledge Sharing Behavior with the Mediating Role of Job Satisfaction: Application of Social Exchange Theory Open
This study aims to explore the impact of despotic leadership (DL) on employee knowledge-sharing behaviors (KSBs) by examining the mediating role of job satisfaction (JS) within the framework of social exchange theory. Data were collected u…
View article: Effect of Intravenous Hydration on Oligohydramnios: A Quasi-Experimental Study from a Tertiary Care Setting
Effect of Intravenous Hydration on Oligohydramnios: A Quasi-Experimental Study from a Tertiary Care Setting Open
Background: Oligohydramnios, characterized by reduced amniotic fluid volume, is a pregnancy complication associated with adverse maternal and fetal outcomes. Despite evidence supporting maternal hydration, variability in response and limit…
View article: RISK FACTORS FOR RECURRENT HOSPITALIZATION INPATIENTS WITH HEART FAILURE WITH REDUCEDEJECTION FRACTION
RISK FACTORS FOR RECURRENT HOSPITALIZATION INPATIENTS WITH HEART FAILURE WITH REDUCEDEJECTION FRACTION Open
Background: Heart failure with reduced ejection fraction (HFrEF) is a progressive condition contributing to substantial healthcare burden due to frequent hospital readmissions. Timely identification of associated risk factors is essential …
View article: The Role of Quality Enhancement Cell in Relation to Culture of Quality and Students’ Academic Performance
The Role of Quality Enhancement Cell in Relation to Culture of Quality and Students’ Academic Performance Open
This paper seeks to understand the impact of culture of quality (COQ) on students’ academic performance and examines the moderating influence of QECs at a university in a private sector. The target population is university student who are …
View article: The Role of Quality Enhancement Cell in Relation to Culture of Quality and Students’ Academic Performance
The Role of Quality Enhancement Cell in Relation to Culture of Quality and Students’ Academic Performance Open
This paper seeks to understand the impact of culture of quality (COQ) on students’ academic performance and examines the moderating influence of QECs at a university in a private sector. The target population is university student who are …
View article: How Vacations Influence Burnout, Stress, and Employee Performance: A Comprehensive Review
How Vacations Influence Burnout, Stress, and Employee Performance: A Comprehensive Review Open
Burnout is key concern for researchers in the current organizational setup. The impacts of burnout are clearly visible in the performance and productivity of employees. Keeping it in view this article is framed under systematic review desi…
View article: Experimental evaluation of mechanically stabilized earth walls reinforced with glass fiber reinforced polymer bars embedded in marble waste-sand mixtures
Experimental evaluation of mechanically stabilized earth walls reinforced with glass fiber reinforced polymer bars embedded in marble waste-sand mixtures Open
This paper presents evaluation of Face Deflection (FD) and Vertical Settlement (VS) of large-scale Mechanically Stabilized Earth (MSE) wall model having (length, width, height) of (1.23 m, 0.92 m, 1.53 m) respectively. The backfill materia…
View article: In Silico Analysis of CYP1B1 Gene Mutations in Pakistani Families Reveals Structural and Functional Characteristics
In Silico Analysis of CYP1B1 Gene Mutations in Pakistani Families Reveals Structural and Functional Characteristics Open
Background: Mutations in the CYP1B1 gene have been associated with primary congenital glaucoma (PCG), a developmental visual disorder. CYP1B1 mutations have been linked to increased lipid peroxidation and abnormalities in trabecular meshwo…
View article: The Impact of Semantic Ambiguity on Social Media Jokes: A Study of Wordplay and Relevance Theory
The Impact of Semantic Ambiguity on Social Media Jokes: A Study of Wordplay and Relevance Theory Open
This study explores how introducing double meanings through semantic ambiguity contributes to humour in-jokes. The research aims to identify the dual role of ambiguity in facilitating humour while preventing communication failure. The rese…
View article: SERS-assisted characterization of cell biomass from biofilm-forming <i>Acinetobacter baumannii</i> strains using chemometric tools
SERS-assisted characterization of cell biomass from biofilm-forming <i>Acinetobacter baumannii</i> strains using chemometric tools Open
Acinetobacter baumannii ( A. baumannii ) is an emerging Gram-negative nosocomial pathogen responsible for infection on a global scale.
View article: Correction: SERS-assisted characterization of cell biomass from biofilm-forming <i>Acinetobacter baumannii</i> strains using chemometric tools
Correction: SERS-assisted characterization of cell biomass from biofilm-forming <i>Acinetobacter baumannii</i> strains using chemometric tools Open
Correction for ‘SERS-assisted characterization of cell biomass from biofilm-forming Acinetobacter baumannii strains using chemometric tools’ by Arslan Yousaf et al. , RSC Adv. , 2025, 15 , 4581–4592, https://doi.org/10.1039/D4RA06267A.
View article: Does Leadership Reduce Employee Turnover Intentions and Retain Employees? An Investigation into NGO Sector of Peshawar
Does Leadership Reduce Employee Turnover Intentions and Retain Employees? An Investigation into NGO Sector of Peshawar Open
Leadership is way different in NGOs when compared to for profit organizations as leaders are required to keep employees motivated toward work under unfavorable conditions and constrained circumstances. In an unstable and terrorism-stricken…
View article: Unraveling the Genetic Basis of Congenital Limb Anomalies in Eight Families
Unraveling the Genetic Basis of Congenital Limb Anomalies in Eight Families Open
Limb abnormalities are the second most frequent birth defects seen in infants, after congenital heart disease. Over the past 150 years, more than 50 classifications for limb malformations based on morphology and osseous anatomy have been p…