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View article: Identification and Evaluation of IGF1R and Its Associated Proteins as Targets and Design of Novel Inhibitors for Cancer Therapy
Identification and Evaluation of IGF1R and Its Associated Proteins as Targets and Design of Novel Inhibitors for Cancer Therapy Open
The insulin‐like growth factor 1 receptor (IGF1R) is a crucial receptor tyrosine kinase involved in cellular growth, survival, and metabolism. Abnormal overexpression and activation are common in various cancers and contribute to tumor dev…
View article: Discovery of a novel and highly selective JAK3 inhibitor as a potent hair growth promoter
Discovery of a novel and highly selective JAK3 inhibitor as a potent hair growth promoter Open
JAK-STAT signalling pathway inhibitors have emerged as promising therapeutic agents for the treatment of hair loss. Among different JAK isoforms, JAK3 has become an ideal target for drug discovery because it only regulates a narrow spectru…
View article: Identification of a stretch of four discontinuous amino acids involved in regulating kinase activity of IGF1R
Identification of a stretch of four discontinuous amino acids involved in regulating kinase activity of IGF1R Open
IGF1R is pursued as a therapeutic target because of its abnormal expression in various cancers. Recently, we reported the presence of a putative allosteric inhibitor binding pocket in IGF1R that could be exploited for developing novel anti…