Patricia Franco
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Clinical, Sleep, and Chronobiological Characteristics of Children with Smith–Magenis Syndrome Under Treatment for Sleep Disorders Open
Background/Objectives: Smith–Magenis Syndrome (SMS) is a rare neurodevelopmental disorder characterized by severe sleep disturbances and an advanced melatonin rhythm. Current treatments, mainly exogenous melatonin and β-blockers, have not …
View article: A Quest for a Histaminergic or Orexinergic Biomarker for Sudden Infant Death Syndrome
A Quest for a Histaminergic or Orexinergic Biomarker for Sudden Infant Death Syndrome Open
Aims This study aimed to investigate the role of the Hypocretin/Orexin (Ox) and Histamine (HA) systems—two key regulators of wakefulness —in sudden infant death syndrome (SIDS), a condition characterized by impaired arousal responses durin…
Comorbid Insomnia and Sleep Apnea Across the Pediatric Age: A Polysomnographic Study Open
Background/Objectives: Comorbid insomnia and sleep apnea (COMISA) in children is poorly documented. This study aimed to evaluate the frequency of COMISA and to explore its clinical and polysomnographic characteristics in children referred …
Feasibility and efficacy of exercise training on sleep symptoms and comorbidities in narcolepsy type 1: a prospective interventional study Open
Current treatments for narcolepsy type 1 (NT1) have little impact on psychiatric, cognitive, and metabolic comorbidities. Here, we evaluated the feasibility, safety, and efficacy of a prospective exercise training (ET) program on sleep-rel…
Identification of novel genetic, neurobiological and radio-anatomical biomarkers for risk stratification of sudden unexpected death in infancy and early childhood: the BIOMINRISK study protocol Open
Introduction The BIOMINRISK project is a national French study aimed at identifying novel biomarkers associated with sudden unexpected death in infancy (SUDI) through a multidisciplinary approach encompassing three key components of intrin…
Utility of Pulse Wave Amplitude Drops in Assessing the Severity of Obstructive Sleep Apnea in Children and Adolescents Open
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Respiratory polygraphy combined with pulse wave amplitude drops for the diagnosis of obstructive sleep apnea in pediatric patients Open
Respiratory polygraphy (RP) underestimates the obstructive apnea-hypopnea index (OAHI) compared to polysomnography (PSG) because it does not account for respiratory events associated with cortical arousals. To address this issue, RP can in…
Gender Inequality in Managing Childhood Sleep: Which Parent Gets up at Night? Open
Objective: Parental responsibilities for childcare remain unequally distributed between mothers and fathers. This study investigates whether such gender disparity also applies to night-time care, particularly when children experience sleep…
View article: New cross-disciplinary sleep medicine residency in France: Results after five years
New cross-disciplinary sleep medicine residency in France: Results after five years Open
The new cross-disciplinary sleep medicine residency program (SMR) was created in 2017 in France and effectively implemented beginning in 2019. This first French specific sleep medicine residency program aims to train specialists in sleep m…
P-923. Characterization of the use of the FilmArray Molecular panel for the diagnosis of central nervous system infection Open
Background The Biofire FilmArray® Meningitis/Encephalitis Panel (FAME) has proven to be a valuable tool for etiological diagnosis. Despite this, we know little about its clinical impact.This investigation aims to characterize the clinical,…
View article: Behavioral and Electrophysiological Markers of Attention Fluctuations in Children with Hypersomnolence
Behavioral and Electrophysiological Markers of Attention Fluctuations in Children with Hypersomnolence Open
Background. No device is yet available to effectively capture the attentional repercussions of hypersomnolence (HYP). The present study aimed to compare attentional performance of children with HYP, attention deficit hyperactivity disorder…
Effectiveness of an intervention program on physical activity in children with narcolepsy type 1 Open
Most children with NT1 showed satisfying PA levels despite their daytime sleepiness. LTPA engagement was associated with higher quality of life. An APA intervention could be effective in children with narcolepsy, especially for those with …
Treatment for behavioral insomnia in young children with neurotypical development under 6 years of age: A systematic review Open
This literature review examines all treatments for behavioral insomnia in children under 6 years of age to determine which treatments have empirically demonstrated efficacy. Following PRISMA guidelines, three databases were investigated (P…
View article: Academic and socio-professional trajectories in narcolepsy type 1: the NARCOSCOL-NARCOVITAE multicentric study
Academic and socio-professional trajectories in narcolepsy type 1: the NARCOSCOL-NARCOVITAE multicentric study Open
Background and objectives Narcolepsy type 1 (NT1) is a chronic, disabling neurological disease. Sleep-related symptoms and comorbidities such as psycho-cognitive disturbances, and a frequent childhood onset of the disease may negatively im…
Hypoventilation in patients with Prader‐Willi syndrome across the pediatric age Open
Objectives Few data on alveolar hypoventilation in Prader‐Willi syndrome (PWS) are available and the respiratory follow‐up of these patients is not standardized. The objectives of this study were to evaluate the prevalence of alveolar hypo…
View article: Pharmacological management of narcolepsy in children and adolescents
Pharmacological management of narcolepsy in children and adolescents Open
Dear Editor, Narcolepsy is often a paediatric disorder with symptoms that can commence in early childhood, and new diagnoses that peak at 15 years of age (Postiglione et al., 2018). For this reason we need controlled safe and effective pha…
Sleep Stage Transitions and Sleep-Dependent Memory Consolidation in Children with Narcolepsy–Cataplexy Open
Electroencephalographic sleep stage transitions and altered first REM sleep period transitions have been identified as biomarkers of type 1 narcolepsy in adults, but not in children. Studies on memory complaints in narcolepsy have not yet …
Does the brain sleep differently depending on intellectual abilities? Open
Aims To compare the children's sleep electroencephalogram according to their intellectual profile. Methods Children were grouped according to their Wechsler Intelligence Scale for Children (WISC) scores (17 with normal intelligence quotien…
View article: Scar architecture determinants of ventricular arrhythmias in patients with hypertrophic cardiomyopathy: a cardiac magnetic resonance study
Scar architecture determinants of ventricular arrhythmias in patients with hypertrophic cardiomyopathy: a cardiac magnetic resonance study Open
Funding Acknowledgements Type of funding sources: None. Background Hypertrophic cardiomyopathy (HCM) patients with extensive cardiac magnetic resonance (CMR) late gadolinium enhancement (LGE) are at greater risk of ventricular arrhythmias …
The critical isthmus of left atrial anterior wall flutter is mostly circumscribed into a small area immediately behind the aortic root. Implications for catheter ablation Open
Funding Acknowledgements Type of funding sources: None. Background Left atrial flutters (LAFL) are typically observed in patients with previous ablation lines or surgery in the left atrium (LA). Less frequently, scar-related left atrial an…
Head up tilt test response patterns in patients undergoing cardioneuroablation Open
Funding Acknowledgements Type of funding sources: None. Background Vasovagal syncope (VVS) is the most common cause of transient loss of consciousness. It severely affects quality of life and can often lead to severe trauma and fatal accid…
Gas exchange parameters for the prediction of obstructive sleep apnea in infants Open
Objectives/background: Sleep laboratory polysomnography (PSG) is the gold standard for obstructive sleep apnea (OSA) diagnosis in infants, but its access remains limited. Another simple and widely used tool, oximetry-capnography can provid…
Metabolic disturbances in children with narcolepsy: a retrospective study Open
Study objectives To determine the prevalence of metabolic syndrome (MS) in children with narcolepsy and to evaluate their clinical and sleep characteristics according to the different components of MS. Methods This retrospective study cons…
Periodic breathing beyond the neonatal period: a case series Open
Introduction: Periodic breathing (PB) is considered physiological in the neonatal period but must disappear in the first months of life. Few data regarding PB after the neonatal period are available. The objective of this study was to desc…
Expert Advice on Child Sleep Bibliotherapy: Anyone can Write Anything Open
The present study aims to assess the quality of self-help books on the subject of children's sleep.Method: An international committee of specialized pediatricians and psychologists established 37 criteria in terms of quality and recommenda…