Farid Abedin Dorkoosh
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View article: Development, optimization, and characterization of vitamin C-fortified oleogel-based chewable gels and a novel nondestructive analysis method for the vitamin C assay
Development, optimization, and characterization of vitamin C-fortified oleogel-based chewable gels and a novel nondestructive analysis method for the vitamin C assay Open
Chewable gels represent an excellent alternative to oral dosage forms, such as tablets and capsules, owing to their appealing appearance, easy swallowing, and attractive colors. Given the inherent instability of vitamin C, particularly wit…
View article: Targeted Delivery of Anticancer Drug Loaded Charged PLGA Polymeric Nanoparticles Using Electrostatic Field
Targeted Delivery of Anticancer Drug Loaded Charged PLGA Polymeric Nanoparticles Using Electrostatic Field Open
View article: A novel controlled release implant of insulin based on Poly (3- hydroxybutyrate-co-3-hydroxyvalerate) polymer prepared by extrusion process
A novel controlled release implant of insulin based on Poly (3- hydroxybutyrate-co-3-hydroxyvalerate) polymer prepared by extrusion process Open
In this study, for the first time, a controlled release implant of insulin has been developed based on a PHBV polymer. In this method, the extrusion process has been used, which provides the possibility of preparing implants on an industri…
View article: Co-Delivery of Paclitaxel and Regorafenib by F127/TPGS Mixed Micelles for Triple Negative Breast Cancer Treatment
Co-Delivery of Paclitaxel and Regorafenib by F127/TPGS Mixed Micelles for Triple Negative Breast Cancer Treatment Open
View article: Electrospun Fibers: Versatile Approaches for Controlled Release Applications
Electrospun Fibers: Versatile Approaches for Controlled Release Applications Open
Electrospinning has been one of the most attractive methods of fiber fabrication in the last century. A lot of studies have been conducted, especially in tissue engineering and drug delivery using electrospun fibers. Loading many different…
View article: Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers
Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers Open
The oral administration of therapeutic peptides and proteins is favoured from a patient and commercial point of view. In order to reach the systemic circulation after oral administration, these drugs have to overcome numerous barriers incl…
View article: Magnetic Hydrogel for Cartilage Tissue Regeneration as well as a Review on Advantages and Disadvantages of Different Cartilage Repair Strategies
Magnetic Hydrogel for Cartilage Tissue Regeneration as well as a Review on Advantages and Disadvantages of Different Cartilage Repair Strategies Open
There is a clear clinical need for efficient cartilage healing strategies for treating cartilage defects which burdens millions of patients physically and financially. Different strategies including microfracture technique, osteochondral t…
View article: In-depth multidisciplinary review of the usage, manufacturing, regulations & market of dietary supplements
In-depth multidisciplinary review of the usage, manufacturing, regulations & market of dietary supplements Open
View article: Nanobodies as powerful pulmonary targeted biotherapeutics against SARS-CoV-2, pharmaceutical point of view
Nanobodies as powerful pulmonary targeted biotherapeutics against SARS-CoV-2, pharmaceutical point of view Open
View article: Fabrication, Optimization, and In Vitro and In Vivo Characterization of Intra-vitreal Implant of Budesonide Generally Made of PHBV
Fabrication, Optimization, and In Vitro and In Vivo Characterization of Intra-vitreal Implant of Budesonide Generally Made of PHBV Open
View article: A Novel Approach for Development of Intraocular Biodegradable Ranibizumab Implant: A Solution for Stability of Protein Activity
A Novel Approach for Development of Intraocular Biodegradable Ranibizumab Implant: A Solution for Stability of Protein Activity Open
Purpose: Ranibizumab is a monoclonal antibody fragment, targeting all isoforms of vascular endothelial growth factor A (VEGF-A), a protein involved in angiogenesis. It is used to treat age-related macular degeneration (AMD), retinal vein o…
View article: Art and drug delivery system design: dissonance or a harmony?
Art and drug delivery system design: dissonance or a harmony? Open
As usual, the article might need a brief introduction on the subject it covers; however, in this very special and apparently odd topic, it needs a more detail and broader look as two seemingly diff...
View article: <p>Synthesis and Characterization of a Novel Peptide-Grafted Cs and Evaluation of Its Nanoparticles for the Oral Delivery of Insulin, in vitro, and in vivo Study [Retraction]</p>
Synthesis and Characterization of a Novel Peptide-Grafted Cs and Evaluation of Its Nanoparticles for the Oral Delivery of Insulin, in vitro, and in vivo Study [Retraction] Open
[This retracts the article DOI: 10.2147/IJN.S161240.].
View article: Chloroquine: a brand-new scenario for an old drug
Chloroquine: a brand-new scenario for an old drug Open
Chloroquine (CQ), most commonly known as an anti-malaria drug, has a long history of use in the prevention and treatment of malaria, amebiasis and further found effective in some autoimmune disorde...
View article: Comparison of 0.2% chlorhexidine mouthwash with and without anti-discoloration system in patients with chronic periodontitis: A randomized controlled clinical trial
Comparison of 0.2% chlorhexidine mouthwash with and without anti-discoloration system in patients with chronic periodontitis: A randomized controlled clinical trial Open
Background. Chemical plaque control, an adjunct to mechanical approaches, could improve the maintenance of patients with different types of periodontitis. Chlorhexidine, the gold standard in chemical plaque control, might have some side ef…
View article: Sustained delivery of olanzapine from sunflower oil‐based polyol‐urethane nanoparticles synthesised through a cyclic carbonate ring‐opening reaction
Sustained delivery of olanzapine from sunflower oil‐based polyol‐urethane nanoparticles synthesised through a cyclic carbonate ring‐opening reaction Open
The forefront horizon of biomedical investigations in recent decades is parcelling‐up and delivery of drugs to achieve controlled/targeted release. In this regard, developing green‐based delivery systems for a spatiotemporal controlling th…
View article: Preparation of curcumin-loaded PLGA nanoparticles and investigation of its cytotoxicity effects on human glioblastoma U87MG cells
Preparation of curcumin-loaded PLGA nanoparticles and investigation of its cytotoxicity effects on human glioblastoma U87MG cells Open
Curcumin, an herbal derivative, could be used as anticancer agent in drug delivery. Due to hydrophobic properties of curcumin, its bioavailability decreases to cancer cells. The aim of this study was to prepare curcumin loaded poly (lactic…
View article: A novel 5-Fluorouracil targeted delivery to colon cancer using folic acid conjugated liposomes
A novel 5-Fluorouracil targeted delivery to colon cancer using folic acid conjugated liposomes Open
The aim of this study was to develop and characterize 5-Fluorouracil (5FU) containing targeted liposomes in order to enhance the efficacy and safety of the drug. Folic acid (FA) was used as a targeting ligand. The in vitro cytotoxicity of …
View article: Synthesis and characterization of a novel peptide-grafted Cs and evaluation of its nanoparticles for the oral delivery of insulin, in vitro, and in vivo study
Synthesis and characterization of a novel peptide-grafted Cs and evaluation of its nanoparticles for the oral delivery of insulin, in vitro, and in vivo study Open
The results indicate that nanoparticles developed from this new peptide conjugated derivative of chitosan are very promising for oral delivery of proteins and peptides.
View article: Investigation of Effective Parameters on Size of Paclitaxel Loaded PLGA Nanoparticles
Investigation of Effective Parameters on Size of Paclitaxel Loaded PLGA Nanoparticles Open
Purpose: The size of polymeric nanoparticles is considered as an effective factor in cancer therapy due to enterance into tumor tissue via the EPR effect. The purpose of this work was to investigate the effective parameters o…
View article: Nanoparticles Prepared From N,N-Dimethyl-N-Octyl Chitosan as the Novel Approach for Oral Delivery of Insulin: Preparation, Statistical Optimization and <i>In-vitro</i> Characterization.
Nanoparticles Prepared From N,N-Dimethyl-N-Octyl Chitosan as the Novel Approach for Oral Delivery of Insulin: Preparation, Statistical Optimization and <i>In-vitro</i> Characterization. Open
In this study, N,N-Dimethyl-N-Octyl chitosan was synthesized. Nanoparticles containing insulin were prepared using PEC method and were statistically optimized using the Box-Behnken response surface methodology. The independent factors were…
View article: A novel nanoemulsion-based method to produce ultrasmall, water-dispersible nanoparticles from chitosan, surface modified with cell-penetrating peptide for oral delivery of proteins and peptides
A novel nanoemulsion-based method to produce ultrasmall, water-dispersible nanoparticles from chitosan, surface modified with cell-penetrating peptide for oral delivery of proteins and peptides Open
A simple and reproducible water-in-oil (W/O) nanoemulsion technique for making ultrasmall (<15 nm), monodispersed and water-dispersible nanoparticles (NPs) from chitosan (CS) is reported. The nano-sized (50 nm) water pools of the W/O nanoe…
View article: Liposome-targeted delivery for highly potent drugs
Liposome-targeted delivery for highly potent drugs Open
Considerable adverse side effects and cytotoxicity of highly potent drugs for healthy tissue require the development of novel drug delivery systems to improve pharmacokinetics and result in selective distribution of the loaded agent. The i…
View article: An Estimation of the Potential Utilization in Iranian Pharmaceutical Industry Involved in the Stock Exchange, 2008-2012.
An Estimation of the Potential Utilization in Iranian Pharmaceutical Industry Involved in the Stock Exchange, 2008-2012. Open
The aim of this study was to measure the potential of production and the capacity used in the pharmaceutical industry. Capacity use is the actual production rate to the potential output, which reflects the gap between actual production and…
View article: Mesoporous silica nanoparticles functionalized with folic acid/methionine for active targeted delivery of docetaxel
Mesoporous silica nanoparticles functionalized with folic acid/methionine for active targeted delivery of docetaxel Open
Mesoporous silica nanoparticles (MSNs) are known as carriers with high loading capacity and large functionalizable surface area for target-directed delivery. In this study, a series of docetaxel-loaded folic acid- or methionine-functionali…
View article: Health-Related Quality of Life and Health Utility Values in Beta Thalassemia Major Patients Receiving Different Types of Iron Chelators in Iran.
Health-Related Quality of Life and Health Utility Values in Beta Thalassemia Major Patients Receiving Different Types of Iron Chelators in Iran. Open
Background: Thalassemia is a chronic, inherited blood disorder, which in its most severe form, causes life-threatening anemia. Thalassemia patients not only engage with difficulties of blood transfusion and iron chelating therapy bu…
View article: Design and Characterization of Mesalamine Loaded Nanoparticles for Controlled Delivery System
Design and Characterization of Mesalamine Loaded Nanoparticles for Controlled Delivery System Open
Objective(s): Nanoparticles (NPs) are known for their specific accumulation in the inflamed tissues of the colon and thus allow a selective delivery to the site of inflammation with minimum adverse effects. The main objective of this work …
View article: Preparation and Bioavailability Analysis of Ferrous Bis Alanine Chelate as a New Micronutrient for Treatment of Iron Deficiency Anemia
Preparation and Bioavailability Analysis of Ferrous Bis Alanine Chelate as a New Micronutrient for Treatment of Iron Deficiency Anemia Open
Purpose: One of the most nutritional disorders around the world is iron deficiency. A novel iron compound was synthesized by chelating ferrous ions with alanine for prevention and treatment of iron deficiency anemia. Me…
View article: Pluronic based nano-delivery systems; Prospective warrior in war against cancer
Pluronic based nano-delivery systems; Prospective warrior in war against cancer Open
Pluronic based nano-particulate systems are innovative platforms for delivery of anti-cancer agents. These systems due to their pharmacological properties and suitable physicochemical characteristics are great opportunity for development c…