Farid Khallouki
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View article: Induction of Extrinsic Apoptotic Pathway in Pancreatic Cancer Cells by Apteranthes europaea Root Extract
Induction of Extrinsic Apoptotic Pathway in Pancreatic Cancer Cells by Apteranthes europaea Root Extract Open
Pancreatic cancer is an extremely deadly disease with few effective treatment options and the lowest survival rate among all types of cancer. As a result, there is an urgent need for the development of new and more effective treatment stra…
View article: A comprehensive machine learning for high throughput Tuberculosis sequence analysis, functional annotation, and visualization
A comprehensive machine learning for high throughput Tuberculosis sequence analysis, functional annotation, and visualization Open
With human guidance, computers now use machine learning (ML) in artificial intelligence (AI) to learn from data, detect trends, and make predictions. Software can adapt and improve with new information. Imaging scans leverage pattern recog…
View article: Ciclopirox-loaded chitosan hydrogel film crosslinked with zinc oxide: a novel sustained-release system for enhanced wound healing and antifungal therapy
Ciclopirox-loaded chitosan hydrogel film crosslinked with zinc oxide: a novel sustained-release system for enhanced wound healing and antifungal therapy Open
View article: Analgesic and toxicological evaluation of cannabidiol-rich Moroccan <i>Cannabis sativa</i> L. (Khardala variety) extract: Evidence from an <i>in vivo</i> and <i>in silico</i> study
Analgesic and toxicological evaluation of cannabidiol-rich Moroccan <i>Cannabis sativa</i> L. (Khardala variety) extract: Evidence from an <i>in vivo</i> and <i>in silico</i> study Open
The legalization of cannabis for industrial and medicinal purposes has significantly expanded worldwide. This study delves into the analgesic potential toxicity study of chloroformic extract from the Moroccan Cannabis sativa L. ( C. sativa…
View article: Authentication of <i>Ziziphus lotus</i> Honey from the Middle Atlas Mountains of Morocco: Physicochemical Properties, Mineral Content, Sugar, Polyphenol Profiles, and Antioxidant Capacity
Authentication of <i>Ziziphus lotus</i> Honey from the Middle Atlas Mountains of Morocco: Physicochemical Properties, Mineral Content, Sugar, Polyphenol Profiles, and Antioxidant Capacity Open
The jujube honey from the Moroccan Middle Atlas area is thoroughly described in this study, which takes into account melissopalynological, physicochemical, antioxidant, mineral, and phytochemical characteristics. Twelve samples of jujube h…
View article: Phytochemical analysis and pharmacological activities of essential oils extracted from <i>Zingiber officinale</i> (Roscoe) used in mediterranean diet: <i>in vitro</i> and in <i>silico</i> studies
Phytochemical analysis and pharmacological activities of essential oils extracted from <i>Zingiber officinale</i> (Roscoe) used in mediterranean diet: <i>in vitro</i> and in <i>silico</i> studies Open
For their pungency and tanginess, ginger rhizomes (Zingiber officinale) are often used in cooking. Ginger has long been used in traditional medicine and home remedies to treat pain and inflammation. This research tests Z. officinale (EOZ) …
View article: Revealing the Potency of Growth Factors in Bovine Colostrum
Revealing the Potency of Growth Factors in Bovine Colostrum Open
Colostrum is a nutritious milk synthesized by mammals during the postpartum period, and its rich bioactive components has led to a global increase in the consumption of bovine colostrum as a supplement. Bovine colostrum contains key compon…
View article: Assessment of Vitamin D Status in the Drâa-Tafilalet Population (Morocco) Based on Sociodemographic, Health, and Nutritional Factors
Assessment of Vitamin D Status in the Drâa-Tafilalet Population (Morocco) Based on Sociodemographic, Health, and Nutritional Factors Open
The purpose of this study was to evaluate the vitamin D status and determine the factors influencing it in the Drâa-Tafilalet community (southeastern Morocco). Sociodemographic factors, health, cognitive status, sun exposure, and nutrition…
View article: Phytochemical Analysis, Antioxidant, Analgesic, Anti-Inflammatory, Hemagglutinin and Hemolytic Activities of Chemically Characterized Extracts from Origanum grosii (L.) and Thymus pallidus (L.)
Phytochemical Analysis, Antioxidant, Analgesic, Anti-Inflammatory, Hemagglutinin and Hemolytic Activities of Chemically Characterized Extracts from Origanum grosii (L.) and Thymus pallidus (L.) Open
Origanum grosii (L.) and Thymus pallidus (L.) are medicinal plants recognized for their uses in traditional medicine. In this context, the aim of this article is to highlight the results of a phytochemical analysis (HPLC), with particular …
View article: Ionomic analysis, polyphenols characterization, analgesic, antiinflammatory and antioxidant capacities of Cistus laurifolius leaves: in vitro, in vivo, and in silico investigations
Ionomic analysis, polyphenols characterization, analgesic, antiinflammatory and antioxidant capacities of Cistus laurifolius leaves: in vitro, in vivo, and in silico investigations Open
This study aims to investigate the chemical and mineral composition, antioxidant, analgesic, and anti-inflammatory effects of the aqueous extract of Cistus laurifolius var. atlanticus Pit. (Cistaceae). Additionally, molecular docking inter…
View article: Napthyridine-derived compounds as promising inhibitors for Staphylococcus aureus CrtM: a primer for the discovery of potential anti-Staphylococcus aureus agents
Napthyridine-derived compounds as promising inhibitors for Staphylococcus aureus CrtM: a primer for the discovery of potential anti-Staphylococcus aureus agents Open
The disease-free existence of humans is constantly under attack by a variety of infections caused by a variety of organisms including bacteria. Notable among the bacteria is Staphylococcus aureus which is an etiological organism for infect…
View article: Physicochemical Characterization of Clay and Study of Cationic Methylene Blue Dye Adsorption
Physicochemical Characterization of Clay and Study of Cationic Methylene Blue Dye Adsorption Open
In an attempt to examine novel adsorbents in accessing an ideal adsorption system, this study aimed to help understand the main and secondary characteristics of a Moroccan natural clay. X-ray fluorescence, infrared, and scanning electron m…
View article: Thymus atlanticus: A Source of Nutrients with Numerous Health Benefits and Important Therapeutic Potential for Age-Related Diseases
Thymus atlanticus: A Source of Nutrients with Numerous Health Benefits and Important Therapeutic Potential for Age-Related Diseases Open
Thymus atlanticus (Lamiaceae) is a plant endemic to the Mediterranean basin that is found in significant quantities in the arid regions of Morocco. Thymus atlanticus is used in traditional medicine to treat infectious and non-infectious di…
View article: Correction to: Assessment of impacts of industrial effluents on physico-chemical and microbiological qualities of irrigation water of the Fez River, Morocco
Correction to: Assessment of impacts of industrial effluents on physico-chemical and microbiological qualities of irrigation water of the Fez River, Morocco Open
View article: An Update on Tamoxifen and the Chemo-Preventive Potential of Vitamin E in Breast Cancer Management
An Update on Tamoxifen and the Chemo-Preventive Potential of Vitamin E in Breast Cancer Management Open
Breast cancer (BC) is the most common female cancer in terms of incidence and mortality worldwide. Tamoxifen (Nolvadex) is a widely prescribed, oral anti-estrogen drug for the hormonal treatment of estrogen-receptor-positive BC, which repr…
View article: Mineral composition, principal polyphenolic components, and evaluation of the anti-inflammatory, analgesic, and antioxidant properties of <i>Cytisus villosus</i> Pourr leaf extracts
Mineral composition, principal polyphenolic components, and evaluation of the anti-inflammatory, analgesic, and antioxidant properties of <i>Cytisus villosus</i> Pourr leaf extracts Open
Cytisus villosus Pourr. ( C. villosus ) is a medicinal plant belonging to the Fabaceae family, which grows in the Mediterranean area. It is used in traditional medicine against diseases related to inflammation. The objective of the present…
View article: Prefatory<i>in silico</i>studies and<i>in vitro</i>insecticidal effect of<i>Nigella sativa</i>(L.) essential oil and its active compound (carvacrol) against the<i>Callosobruchus maculatus</i>adults (Fab), a major pest of chickpea
Prefatory<i>in silico</i>studies and<i>in vitro</i>insecticidal effect of<i>Nigella sativa</i>(L.) essential oil and its active compound (carvacrol) against the<i>Callosobruchus maculatus</i>adults (Fab), a major pest of chickpea Open
To help discover a reasonable and eco-friendly insecticide, we undertook a study on the insecticidal potential of carvacrol and essential oils extracted by hydrodistillation using a Clevenger apparatus from the plant species Nigella sativa…
View article: First Survey on Behavior and Preferences Towards Honey Consumption by the Eastern Central Moroccan Population
First Survey on Behavior and Preferences Towards Honey Consumption by the Eastern Central Moroccan Population Open
View article: Organic Honey from the Middle Atlas of Morocco: Physicochemical Parameters, Antioxidant Properties, Pollen Spectra, and Sugar Profiles
Organic Honey from the Middle Atlas of Morocco: Physicochemical Parameters, Antioxidant Properties, Pollen Spectra, and Sugar Profiles Open
This work aimed to characterize and compare the physicochemical, ascorbic acid, phenolic, and flavonoid compounds, as well as the antioxidant properties, pollen spectra, and sugar profiles of twenty-three organic honeys produced in the Mid…
View article: GC-MS Characterization, In Vitro Antioxidant, Antimicrobial, and In Silico NADPH Oxidase Inhibition Studies of Anvillea radiata Essential Oils
GC-MS Characterization, In Vitro Antioxidant, Antimicrobial, and In Silico NADPH Oxidase Inhibition Studies of Anvillea radiata Essential Oils Open
Anvillea radiata is a medicinal plant that has been used in traditional phytotherapy in North Africa as a treatment for various illnesses. In this study, we aim to explore the antioxidant, antifungal, and antibacterial effects of essential…
View article: Molecular Characterization of Gene-Mediated Resistance and Susceptibility of ESKAPE Clinical Isolates to Cistus monspeliensis L. and Cistus salviifolius L. Extracts
Molecular Characterization of Gene-Mediated Resistance and Susceptibility of ESKAPE Clinical Isolates to Cistus monspeliensis L. and Cistus salviifolius L. Extracts Open
Background. Multidrug resistance (MDR) and extensively drug-resistant (XDR) are now the biggest threats to human beings. Alternative antimicrobial regimens to conventional antibiotic paradigms are extensively searched. Although Cistus extr…
View article: Antioxidant, Anti-Proliferative Activity and Chemical Fingerprinting of Centaurea calcitrapa against Breast Cancer Cells and Molecular Docking of Caspase-3
Antioxidant, Anti-Proliferative Activity and Chemical Fingerprinting of Centaurea calcitrapa against Breast Cancer Cells and Molecular Docking of Caspase-3 Open
Centaurea calcitrapa has been intensively utilized in ethnomedicinal practices as a natural therapeutic recipe to cure various ailments. The current study aimed to chemically characterize ethanolic extract of C. calcitrapa (EECC) aerial pa…
View article: In vitro and In vivo oxidation and cleavage products of tocols: From chemical tuners to “VitaminEome” therapeutics. A narrative review
In vitro and In vivo oxidation and cleavage products of tocols: From chemical tuners to “VitaminEome” therapeutics. A narrative review Open
View article: Saffron (Crocus sativus L.): A Source of Nutrients for Health and for the Treatment of Neuropsychiatric and Age-Related Diseases
Saffron (Crocus sativus L.): A Source of Nutrients for Health and for the Treatment of Neuropsychiatric and Age-Related Diseases Open
Saffron (Crocus sativus L.) is a medicinal plant, originally cultivated in the East and Middle East, and later in some Mediterranean countries. Saffron is obtained from the stigmas of the plant. Currently, the use of saffron is undergoing …
View article: EFFECT OF HYDRO-ALCOHOL SOLVENT POLARITY ON THEANTIOXIDANT, ANTIBACTERIAL AND ANTI-INFLAMMATORYACTIVITIES OF FOUR MOROCCAN LETTUCE VARIETIES(Lactuca sativa L.): A COMPARATIVE STUDY
EFFECT OF HYDRO-ALCOHOL SOLVENT POLARITY ON THEANTIOXIDANT, ANTIBACTERIAL AND ANTI-INFLAMMATORYACTIVITIES OF FOUR MOROCCAN LETTUCE VARIETIES(Lactuca sativa L.): A COMPARATIVE STUDY Open
View article: HPLC-ESI-MS and GC-EI-MS Identification and Quantitation of Polyphenolics and Alkaloids in Moroccan Jujube Honeys
HPLC-ESI-MS and GC-EI-MS Identification and Quantitation of Polyphenolics and Alkaloids in Moroccan Jujube Honeys Open
The aim of this study was to determine the phytochemical content of Moroccan Jujube Honey and to establish the principal components of this staple Moroccan food, which contributes health benefit for the local population. Total phytochemica…
View article: Cytotoxic activity of Moroccan Melissa officinalis leaf extracts and HPLC-ESI-MS analysis of its phytoconstituents
Cytotoxic activity of Moroccan Melissa officinalis leaf extracts and HPLC-ESI-MS analysis of its phytoconstituents Open
View article: Adherence to the Mediterranean diet of school-age children in Moroccan oases, Draa-Tafilalet Region
Adherence to the Mediterranean diet of school-age children in Moroccan oases, Draa-Tafilalet Region Open
Most of the study population had medium to good adherence to MedDiet, but low KIDMED index was observed. Interventions and strategies should be devised for preserving and promoting healthy eating habits in this target population.
View article: Vitamin E: an overview
Vitamin E: an overview Open
View article: Isolation of the Major Phenolic Compounds in the Pits of Brined Green Olive Drupes: Structure Elucidation by Comprehensive <sup>1</sup>H/<sup>13</sup>C-NMR Spectroscopy
Isolation of the Major Phenolic Compounds in the Pits of Brined Green Olive Drupes: Structure Elucidation by Comprehensive <sup>1</sup>H/<sup>13</sup>C-NMR Spectroscopy Open
Pits of representative green olive drupes from Italy and Greece were evaluated for their content of phenolic compounds. The major purified polyphenols quantitated in mg/kg in the Italian and Greek pit varieties, respectively, were tyrosol …