Farida Hellal
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View article: Deep Learning and 3D Imaging Reveal Whole-Body Alterations in Obesity
Deep Learning and 3D Imaging Reveal Whole-Body Alterations in Obesity Open
Many diseases, such as obesity, have systemic effects that impact multiple organ systems throughout the body. However, tools for comprehensive, high-resolution analysis of disease-associated changes at the whole-body scale have been lackin…
View article: Equilibrium structure and shape of Ag and Pt nanoparticles grown on silica surfaces: From experimental investigations to the determination of a metal–silica potential
Equilibrium structure and shape of Ag and Pt nanoparticles grown on silica surfaces: From experimental investigations to the determination of a metal–silica potential Open
A combination of experimental and numerical investigations on metallic silver and platinum nanoparticles deposited on silica substrates is presented, with a focus on metal–substrate interactions. Experimentally, the nanoparticles, obtained…
View article: Equilibrium structure and shape of Ag and Pt nanoparticles grown on silica surfaces: from experimental investigations to the determination of a metal-silica potential
Equilibrium structure and shape of Ag and Pt nanoparticles grown on silica surfaces: from experimental investigations to the determination of a metal-silica potential Open
A combination of experimental and numerical calculations on metallic silver and platinum nanoparticles deposited on silica substrates is presented, with a focus on the metal-substrate interactions. Experimentally, the nanoparticles are ela…
View article: Focal Cerebral Ischemia Induces Global Subacute Changes in the Number of Neuroblasts and Neurons and the Angiogenic Factor Density in Mice
Focal Cerebral Ischemia Induces Global Subacute Changes in the Number of Neuroblasts and Neurons and the Angiogenic Factor Density in Mice Open
Background and Objectives: Dissecting the complex pathological cascade of an ischemic stroke in preclinical models is highly warranted to understand the course of this disease in humans. Neurogenesis and angiogenesis are integral for post-…
View article: Structural changes of <scp>CA1</scp> pyramidal neurons after stroke in the contralesional hippocampus
Structural changes of <span>CA1</span> pyramidal neurons after stroke in the contralesional hippocampus Open
Significant progress has been made with regard to understanding how the adult brain responds after a stroke. However, a large number of patients continue to suffer lifelong disabilities without adequate treatment. In the present study, we …
View article: Single-cell precision nanotechnology<i>in vivo</i>
Single-cell precision nanotechnology<i>in vivo</i> Open
Targeting nanoparticle therapeutics with cellular accuracy in whole organisms could open breakthrough opportunities in precision medicine. However, evaluating and fine-tuning the biodistribution of such systems in the whole organism at the…
View article: Whole-body cellular mapping in mouse using standard IgG antibodies
Whole-body cellular mapping in mouse using standard IgG antibodies Open
Whole-body imaging techniques play a vital role in exploring the interplay of physiological systems in maintaining health and driving disease. We introduce wildDISCO, a new approach for whole-body immunolabeling, optical clearing and imagi…
View article: SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19
SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19 Open
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), has been associated mainly with a range of neurological symptoms, including brain fog and brain tissue loss, raising conc…
View article: Whole mouse body histology using standard IgG antibodies
Whole mouse body histology using standard IgG antibodies Open
Most diseases involve multiple interconnected physiological systems, but histological evaluation of their pathology is currently limited to small tissue samples. Here, we present wildDISCO, a technology that uses cholesterol extraction to …
View article: Microanatomical study of pyramidal neurons in the contralesional somatosensory cortex after experimental ischemic stroke
Microanatomical study of pyramidal neurons in the contralesional somatosensory cortex after experimental ischemic stroke Open
At present, many studies support the notion that after stroke, remote regions connected to the infarcted area are also affected and may contribute to functional outcome. In the present study, we have analyzed possible microanatomical alter…
View article: Dynamic tracing using ultra-bright labelling and multi-photon microscopy identifies endothelial uptake of poloxamer 188 coated poly(lactic-co-glycolic acid) nano-carriers in vivo.
Dynamic tracing using ultra-bright labelling and multi-photon microscopy identifies endothelial uptake of poloxamer 188 coated poly(lactic-co-glycolic acid) nano-carriers in vivo. Open
The potential of poly(lactic-co-glycolic acid) (PLGA) to design nanoparticles (NPs) and target the central nervous system remains to be exploited. In the current study we designed fluorescent 70-nm PLGA NPs, loaded with bulky fluorophores,…
View article: Multi-omics and 3D-imaging reveal bone heterogeneity and unique calvaria cells in neuroinflammation
Multi-omics and 3D-imaging reveal bone heterogeneity and unique calvaria cells in neuroinflammation Open
SUMMARY The meninges of the brain are an important component of neuroinflammatory response. Diverse immune cells move from the calvaria marrow into the dura mater via recently discovered skull-meninges connections (SMCs). However, how the …
View article: Dynamic tracing using ultra-bright labelling and multi-photon microscopy identifies endothelial uptake of poloxamer 188 coated poly(lactic-co-glycolic acid) nano-carriers<i>in vivo</i>
Dynamic tracing using ultra-bright labelling and multi-photon microscopy identifies endothelial uptake of poloxamer 188 coated poly(lactic-co-glycolic acid) nano-carriers<i>in vivo</i> Open
Poly(lactic-co-glycolic acid) (PLGA)-based drug formulations are approved for the use in humans, however, the potential of PLGA to design nanoparticles (NPs) and target the central nervous system remains to be exploited. The aim of the cur…
View article: Ultrabright Fluorescent Polymeric Nanoparticles with a Stealth Pluronic Shell for Live Tracking in the Mouse Brain
Ultrabright Fluorescent Polymeric Nanoparticles with a Stealth Pluronic Shell for Live Tracking in the Mouse Brain Open
Here, the dataset related with the following: 1. Quantification of the circulation of nanoparticles in mouse blood stream 2. Quantification of individual nanoparticle tracking parameters 3. Quantification of nanoparticles interaction with …
View article: Ultrabright Fluorescent Polymeric Nanoparticles with a Stealth Pluronic Shell for Live Tracking in the Mouse Brain
Ultrabright Fluorescent Polymeric Nanoparticles with a Stealth Pluronic Shell for Live Tracking in the Mouse Brain Open
Visualizing single organic nanoparticles (NPs) in vivo remains a challenge, which could greatly improve our understanding of the bottlenecks in the field of nanomedicine. To achieve high single-particle fluorescence brightness, we loaded p…
View article: Progressive Histopathological Damage Occurring Up to One Year after Experimental Traumatic Brain Injury Is Associated with Cognitive Decline and Depression-Like Behavior
Progressive Histopathological Damage Occurring Up to One Year after Experimental Traumatic Brain Injury Is Associated with Cognitive Decline and Depression-Like Behavior Open
Increasing clinical and experimental evidence suggests that traumatic brain injury (TBI) is associated with progressive histopathological damage. The aim of the current study was to characterize the time course of motor function, memory pe…
View article: Inadequate food and water intake determine mortality following stroke in mice
Inadequate food and water intake determine mortality following stroke in mice Open
Experimental stroke models producing clinically relevant functional deficits are often associated with high mortality. Because the mechanisms that underlie post-stroke mortality are largely unknown, results obtained using these models are …
View article: Dysfunction of Mouse Cerebral Arteries during Early Aging
Dysfunction of Mouse Cerebral Arteries during Early Aging Open
Aging leads to a gradual decline in the fidelity of cerebral blood flow (CBF) responses to neuronal activation, resulting in an increased risk for stroke and dementia. However, it is currently unknown when age-related cerebrovascular dysfu…
View article: Systemic administration of epothilone B promotes axon regeneration after spinal cord injury
Systemic administration of epothilone B promotes axon regeneration after spinal cord injury Open
Progress toward fixing a broken back? Axon regeneration after a spinal cord injury requires interference with neuronal mechanisms to promote axon extension and early suppression of scar formation. Microtubule stabilization could provide, i…
View article: Microglia in action: how aging and injury can change the brain’s guardians
Microglia in action: how aging and injury can change the brain’s guardians Open
Neuroinflammation, the inflammatory response in the central nervous system (CNS), is a major determinant of neuronal function and survival during aging and disease progression. Microglia, as the resident tissue-macrophages of the brain, pr…