Farran Briggs
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View article: Using Generative Models of Naturalistic Scenes to Sample Neural Population Tuning Manifolds
Using Generative Models of Naturalistic Scenes to Sample Neural Population Tuning Manifolds Open
Investigations into sensory coding in the visual system have typically relied on the use of either simple, unnatural visual stimuli or natural images. Simple stimuli, such as Gabor patches, have been effective when looking at single neuron…
View article: Correlated variability and its attentional modulation depend on anatomical connectivity
Correlated variability and its attentional modulation depend on anatomical connectivity Open
Visual cortical neurons show variability in their responses to repeated presentations of a stimulus and a portion of this variability is shared across neurons. Attention may enhance visual perception by reducing shared spiking variability.…
View article: Using generative models of naturalistic scenes to sample neural population tuning manifolds
Using generative models of naturalistic scenes to sample neural population tuning manifolds Open
Investigations into sensory coding in the visual system have typically relied on the use of either simple, unnatural visual stimuli, or natural images. Simple stimuli, such as Gabor patches, have been effective when looking at single neuro…
View article: Parallel Streams of Direct Corticogeniculate Feedback from Mid-level Extrastriate Cortex in the Macaque Monkey
Parallel Streams of Direct Corticogeniculate Feedback from Mid-level Extrastriate Cortex in the Macaque Monkey Open
First-order thalamic nuclei receive feedforward signals from peripheral receptors and relay these signals to primary sensory cortex. Primary sensory cortex, in turn, provides reciprocal feedback to first-order thalamus. Because the vast ma…
View article: Limited Restoration of Contrast Sensitivity with Training after V1 Damage in Humans
Limited Restoration of Contrast Sensitivity with Training after V1 Damage in Humans Open
Stroke damage to the primary visual cortex (V1) causes severe visual deficits, which benefit from perceptual retraining. However, whereas training with high-contrast stimuli can locally restore orientation and motion direction discriminati…
View article: Contrast sensitivity: a fundamental limit to vision restoration after V1 damage
Contrast sensitivity: a fundamental limit to vision restoration after V1 damage Open
Stroke damage to the primary visual cortex (V1) causes severe visual deficits, which benefit from perceptual retraining. However, whereas training with high-contrast stimuli can locally restore orientation and direction discrimination abil…
View article: Poster Session: The impact of retinal excitotoxic lesions on parallel visual streams in the ferret dorsal lateral geniculate nucleus.
Poster Session: The impact of retinal excitotoxic lesions on parallel visual streams in the ferret dorsal lateral geniculate nucleus. Open
Attesting to the relative strength of retinal inputs to the dorsal lateral geniculate nucleus (LGN) of the thalamus, in cats, acute retinal lesions erase responses of LGN neurons whose receptive fields fall within the retinal lesion projec…
View article: Functional ultrasound imaging reveals 3D structure of orientation domains in ferret primary visual cortex
Functional ultrasound imaging reveals 3D structure of orientation domains in ferret primary visual cortex Open
Orientation domains are cones rather than columns. Their width and intra-domain distances may vary across dorsal and ventral regions of V1. These findings demonstrate the power of fUS at revealing 3D functional architecture in cortical reg…
View article: CS Home Training data.xlsx
CS Home Training data.xlsx Open
After baseline measurements in-lab, participants were sent home to train for several months (subacute (SA): 4.9±0.6 months [mean ± SD]; chronic (CH): 6.8±4.0 months). They used their personal computers with a chin/forehead-rest provided by…
View article: CS Home Training data.xlsx
CS Home Training data.xlsx Open
After baseline measurements in-lab, participants were sent home to train for several months (subacute (SA): 4.9±0.6 months [mean ± SD]; chronic (CH): 6.8±4.0 months). They used their personal computers with a chin/forehead-rest provided by…
View article: Relative efficacy of training with low-contrast Gabors in subacute versus chronic cortically-induced blindness
Relative efficacy of training with low-contrast Gabors in subacute versus chronic cortically-induced blindness Open
Stroke damage to the primary visual cortex (V1) causes loss of vision known as cortically-induced blindness (CB). Our prior work showed that high-contrast visual training improves visual functions in both subacute (6 months post-stroke) CB…
View article: The role of corticogeniculate feedback in visual perception
The role of corticogeniculate feedback in visual perception Open
Farran Briggs will describe a series of approaches using traditional and modern tools to explore how cortical feedback influences early visual processing. Transformations in visual signals traversing the feedforward retino-geniculo-cortica…
View article: Optogenetic suppression of corticogeniculate feedback in anesthetized ferrets is overridden by visual stimulation
Optogenetic suppression of corticogeniculate feedback in anesthetized ferrets is overridden by visual stimulation Open
The feedforward projection from the retina shapes the spatial receptive field properties of neurons in the dorsal lateral geniculate nucleus of the thalamus (LGN). Corticogeniculate feedback from the visual cortex appears to exert a more s…
View article: Attention differentially modulates multiunit activity in the lateral geniculate nucleus and <scp>V1</scp> of macaque monkeys
Attention differentially modulates multiunit activity in the lateral geniculate nucleus and <span>V1</span> of macaque monkeys Open
Attention promotes the selection of behaviorally relevant sensory signals from the barrage of sensory information available. Visual attention modulates the gain of neuronal activity in all visual brain areas examined, although magnitudes o…
View article: Physiological characterization of a rare subpopulation of doublet-spiking neurons in the ferret lateral geniculate nucleus
Physiological characterization of a rare subpopulation of doublet-spiking neurons in the ferret lateral geniculate nucleus Open
Interest in visual system homologies across species has recently increased. Across species, retinas contain diverse retinal ganglion cells including cells with unusual visual response properties. It is unclear whether rare retinal ganglion…
View article: Role of Feedback Connections in Central Visual Processing
Role of Feedback Connections in Central Visual Processing Open
The physiological response properties of neurons in the visual system are inherited mainly from feedforward inputs. Interestingly, feedback inputs often outnumber feedforward inputs. Although they are numerous, feedback connections are wea…
View article: Changes in Local Network Activity Approximated by Reverse Spike-Triggered Local Field Potentials Predict the Focus of Attention
Changes in Local Network Activity Approximated by Reverse Spike-Triggered Local Field Potentials Predict the Focus of Attention Open
The effects of visual spatial attention on neuronal firing rates have been well characterized for neurons throughout the visual processing hierarchy. Interestingly, the mechanisms by which attention generates more or fewer spikes in respon…
View article: Neuronal Mechanisms of Attention Measured Through Multi-unit Recordings in LGN and V1
Neuronal Mechanisms of Attention Measured Through Multi-unit Recordings in LGN and V1 Open
Understanding the neural mechanisms of attention has numerous applications to healthcare, education, and workplace efficiency. Despite its interconnected circuitry throughout the brain, the neurophysiological basis of attention is poorly u…
View article: Phase shifts in high-beta- and low-gamma-band local field potentials predict the focus of visual spatial attention
Phase shifts in high-beta- and low-gamma-band local field potentials predict the focus of visual spatial attention Open
The local field potential (LFP) contains rich information about activity in local neuronal populations. However, it has been challenging to establish direct links between LFP modulations and task-relevant behavior or cognitive processes, s…
View article: Attention Enhances the Efficacy of Communication in V1 Local Circuits
Attention Enhances the Efficacy of Communication in V1 Local Circuits Open
Attention is a critical component of visual perception; however, the mechanisms of attention at the granular level are poorly understood. One possible mechanism by which attention modulates neuronal activity is to control the efficacy of c…
View article: Dynamic communication of attention signals between the LGN and V1
Dynamic communication of attention signals between the LGN and V1 Open
Correlations and inferred causal interactions among local field potentials (LFPs) simultaneously recorded in distinct visual brain areas can provide insight into how visual and cognitive signals are communicated between neuronal population…
View article: Corticogeniculate feedback sharpens the temporal precision and spatial resolution of visual signals in the ferret
Corticogeniculate feedback sharpens the temporal precision and spatial resolution of visual signals in the ferret Open
Significance The functional role of corticothalamic circuits, connecting the cortex to the thalamus in the feedback direction, has remained a fundamental mystery in neuroscience. In spite of the fact that corticothalamic inputs are numerou…
View article: Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations
Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations Open
This protocol outlines large-scale reconstructions of neurons combined with the use of independent and unbiased clustering analyses to create a comprehensive survey of the morphological characteristics observed among a selective neuronal p…
View article: A cross-species comparison of corticogeniculate structure and function
A cross-species comparison of corticogeniculate structure and function Open
The corticogeniculate circuit is an evolutionarily conserved pathway linking the primary visual cortex with the visual thalamus in the feedback direction. While the corticogeniculate circuit is anatomically robust, the impact of corticogen…
View article: Morphology of visual sector thalamic reticular neurons in the macaque monkey suggests retinotopically specialized, parallel stream‐mixed input to the lateral geniculate nucleus
Morphology of visual sector thalamic reticular neurons in the macaque monkey suggests retinotopically specialized, parallel stream‐mixed input to the lateral geniculate nucleus Open
The thalamic reticular nucleus (TRN) is a unique brain structure at the interface between the thalamus and the cortex. Because the TRN receives bottom‐up sensory input and top‐down cortical input, it could serve as an integration hub for s…