Farris Al-Manaseer
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View article: Distinct clinicopathological and survival profiles of CLDN18.2 and PD-L1 expression in advanced gastric cancer and gastroesophageal junction adenocarcinoma
Distinct clinicopathological and survival profiles of CLDN18.2 and PD-L1 expression in advanced gastric cancer and gastroesophageal junction adenocarcinoma Open
Background: Claudin 18.2 (CLDN18.2)-targeted therapy and immune checkpoint blockade have transformed the frontline treatment landscape of gastric and gastroesophageal junction (GC/GEJ) cancers, marking a major advance in precision oncology…
View article: PARP inhibitors in gastric cancer: unlocking precision oncology
PARP inhibitors in gastric cancer: unlocking precision oncology Open
Gastric cancer (GC) demonstrates frequent alterations in homologous recombination repair (HRR) genes, and preclinical studies have demonstrated a clear synthetic lethality between HRR deficiency (HRD) and PARPi. While such preclinical synt…
View article: Comparison of Fresh Versus Frozen Allogenic Peripheral Blood Stem Cell Grafts in Hematopoietic Stem Cell Transplantation: A Meta-Analysis and Systematic Review
Comparison of Fresh Versus Frozen Allogenic Peripheral Blood Stem Cell Grafts in Hematopoietic Stem Cell Transplantation: A Meta-Analysis and Systematic Review Open
The COVID-19 pandemic led to the widespread adoption of cryopreserved peripheral blood stem cell (PBSC) grafts in allogeneic hematopoietic stem cell transplantation (HSCT), diverging from the traditional preference for fresh grafts. Althou…
View article: Survival and Treatment Patterns in Stage II to III Esophageal Cancer
Survival and Treatment Patterns in Stage II to III Esophageal Cancer Open
Importance Existing clinical trials favor neoadjuvant chemoradiation therapy (NCRT) followed by surgery alone for locally advanced esophageal cancer (EC) and perioperative chemotherapy as the preferred modality for esophageal adenocarcinom…
View article: Early Administration of Intravenous Hydration and Opioid Analgesics Is Correlated with Decreased Admission Rates during Vaso-Occlusive Episodes in Sickle Cell Disease
Early Administration of Intravenous Hydration and Opioid Analgesics Is Correlated with Decreased Admission Rates during Vaso-Occlusive Episodes in Sickle Cell Disease Open
Background: Painful vaso-occlusive episodes (VOEs) are the hallmark of sickle cell disease (SCD) and account for frequent visits to the emergency department (ED) or urgent care (UC). Currently, the early administration of analgesics is rec…
View article: Perspectives on the Potential Curability of Metastatic Gastric Cancer: Insights from Biomarker-Driven Approaches
Perspectives on the Potential Curability of Metastatic Gastric Cancer: Insights from Biomarker-Driven Approaches Open
View article: Renal infarction - a secondary cause due to aortic dissection
Renal infarction - a secondary cause due to aortic dissection Open