Fashuai Wu
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View article: Identification of Potential Targets for EGFR-Regulated Nucleus Pulposus Degeneration Using Single-Cell RNA Sequencing and Machine Learning
Identification of Potential Targets for EGFR-Regulated Nucleus Pulposus Degeneration Using Single-Cell RNA Sequencing and Machine Learning Open
This study reveals a significant degenerative process in NPC and indicates that EGFR may contribute to this degeneration by regulating JAK1, thereby identifying a potential therapeutic target for delaying IVDD.
View article: Mendelian randomization study reveals the causal effect of sex hormone binding globulin on osteoporosis
Mendelian randomization study reveals the causal effect of sex hormone binding globulin on osteoporosis Open
View article: Overactivation of EGFR signaling in skeletal stem/progenitor cells promotes bone formation and repair
Overactivation of EGFR signaling in skeletal stem/progenitor cells promotes bone formation and repair Open
Background: Epidermal growth factor receptor (EGFR) signaling plays an important role in bone development. However, knowledge of its specific function in skeletal stem cells during bone healing remains scant. Methods: We used…
View article: Discoidin domain receptor 2 is an important modulator of BMP signaling during heterotopic bone formation
Discoidin domain receptor 2 is an important modulator of BMP signaling during heterotopic bone formation Open
View article: Current advances in animal model of meniscal injury: From meniscal injury to osteoarthritis
Current advances in animal model of meniscal injury: From meniscal injury to osteoarthritis Open
Meniscal injury is a prevalent orthopedic practice that causes articular cartilage wear and degeneration due to tissue damage or loss, and may eventually result in the occurrence of knee osteoarthritis (KOA). Hence, investigating the struc…
View article: POLE2 promotes osteosarcoma progression by enhancing the stability of CD44
POLE2 promotes osteosarcoma progression by enhancing the stability of CD44 Open
Osteosarcoma (OS) is the most prevalent primary malignancy of bone in children and adolescents. It is extremely urgent to develop a new therapy for OS. In this study, the GSE14359 chip from the GEO database was used to screen differentiall…
View article: Synthetic peptides activating discoidin domain receptor 2 and collagen‐binding integrins cooperate to stimulate osteoblast differentiation of skeletal progenitor cells
Synthetic peptides activating discoidin domain receptor 2 and collagen‐binding integrins cooperate to stimulate osteoblast differentiation of skeletal progenitor cells Open
View article: A multi-view latent variable model reveals cellular heterogeneity in complex tissues for paired multimodal single-cell data
A multi-view latent variable model reveals cellular heterogeneity in complex tissues for paired multimodal single-cell data Open
Motivation Single-cell multimodal assays allow us to simultaneously measure two different molecular features of the same cell, enabling new insights into cellular heterogeneity, cell development and diseases. However, most existing methods…
View article: Poly(N-Isopropylacrylamide) Based Electrically Conductive Hydrogels and Their Applications
Poly(N-Isopropylacrylamide) Based Electrically Conductive Hydrogels and Their Applications Open
Poly(N-isopropylacrylamide) (PNIPAM) based electrically conductive hydrogels (PNIPAM-ECHs) have been extensively studied in recent decades due to their thermal-responsive (leading to the volume change of hydrogels) and electrically conduct…
View article: Two-Sample Mendelian Randomization Estimates of the Effects of Educational Attainment on Osteoporosis
Two-Sample Mendelian Randomization Estimates of the Effects of Educational Attainment on Osteoporosis Open
View article: Mendelian randomization study of telomere length and bone mineral density
Mendelian randomization study of telomere length and bone mineral density Open
We utilized 5 independent SNPs robustly associated with LTL as instrument variables. The outcome results were obtained from GWAS summary data of BMD. The two-sample MR analysis was conducted using IVW, weighted median, MR-Egger regression …
View article: Mendelian randomization study of inflammatory bowel disease and bone mineral density
Mendelian randomization study of inflammatory bowel disease and bone mineral density Open
Background Recently, the association between inflammatory bowel disease (including ulcerative colitis and Crohn’s disease) and BMD has attracted great interest in the research community. However, the results of the published epidemiologica…
View article: 99mTc-MIBI Scintigraphy for the Preoperative Assessment of Histological Response to Neoadjuvant Chemotherapy in Patients With Osteosarcoma: A Systematic Review and a Bivariate Meta-Analysis
99mTc-MIBI Scintigraphy for the Preoperative Assessment of Histological Response to Neoadjuvant Chemotherapy in Patients With Osteosarcoma: A Systematic Review and a Bivariate Meta-Analysis Open
Purpose: There have been many attempts to preoperatively evaluate the chemotherapy response of osteosarcoma patients using 99mTc-MIBI scintigraphy. However, the evaluations were lacking in consistency. We performed this s…
View article: Correction to: LncRNA AFAP1-AS1 promotes tumorigenesis and epithelial-mesenchymal transition of osteosarcoma through RhoC/ROCK1/p38MAPK/Twist1 signaling pathway
Correction to: LncRNA AFAP1-AS1 promotes tumorigenesis and epithelial-mesenchymal transition of osteosarcoma through RhoC/ROCK1/p38MAPK/Twist1 signaling pathway Open
View article: Additional file 2 of Mendelian randomization study of inflammatory bowel disease and bone mineral density
Additional file 2 of Mendelian randomization study of inflammatory bowel disease and bone mineral density Open
Additional file 2: Table S1. MR estimates from different methods of assessing the causal effect of IBD on BMDs step by step. Table S2. MR estimates from different methods of assessing the causal effect of UC on BMDs step by step. Table S3.…
View article: Additional file 3 of Mendelian randomization study of inflammatory bowel disease and bone mineral density
Additional file 3 of Mendelian randomization study of inflammatory bowel disease and bone mineral density Open
Additional file 3: Figure S1. Funnel plots for MR analyses of the causal effect of IBD on BMDs in initial practice (A) TB-BMD (B) FN-BMD (C) LS-BMD (D) FA-BMD. Figure S2. Plots of “leave-one-out” analyses for MR analyses of the causal effe…
View article: Additional file 1 of Mendelian randomization study of inflammatory bowel disease and bone mineral density
Additional file 1 of Mendelian randomization study of inflammatory bowel disease and bone mineral density Open
Additional file 1 Detailed information of LD-independent SNPs (after clumping process) for exposure (IBD, UC and CD).
View article: Dynasore suppresses cell proliferation, migration, and invasion and enhances the antitumor capacity of cisplatin via STAT3 pathway in osteosarcoma
Dynasore suppresses cell proliferation, migration, and invasion and enhances the antitumor capacity of cisplatin via STAT3 pathway in osteosarcoma Open
Osteosarcoma (OS) is the most common malignant bone tumor. The prognosis of metastatic and recurrent OS patients still remains unsatisfactory. Cisplatin reveals undeniable anti-tumor effect while induces severe side effects that threatenin…
View article: LncRNA AFAP1-AS1 promotes tumorigenesis and epithelial-mesenchymal transition of osteosarcoma through RhoC/ROCK1/p38MAPK/Twist1 signaling pathway
LncRNA AFAP1-AS1 promotes tumorigenesis and epithelial-mesenchymal transition of osteosarcoma through RhoC/ROCK1/p38MAPK/Twist1 signaling pathway Open
Background An increasing number of studies have demonstrated that long non-coding RNAs (lncRNAs) play pivotal roles in cancer onset and development. LncRNA AFAP1-AS1 has been validated to be abnormally upregulated and play oncogenic roles …
View article: Association between TP53 rs1042522 gene polymorphism and the risk of malignant bone tumors: a meta-analysis
Association between TP53 rs1042522 gene polymorphism and the risk of malignant bone tumors: a meta-analysis Open
TP53 is a tumor suppressor gene which is essential for regulating cell division and preventing tumor formation. Several studies have assessed the associations of TP53 single-nucleotide polymorphisms (SNP) with susceptibility of malignant b…
View article: Association of COL9A3 trp3 polymorphism with intervertebral disk degeneration: a meta-analysis
Association of COL9A3 trp3 polymorphism with intervertebral disk degeneration: a meta-analysis Open
View article: Prognostic and clinicopathological significance of DEPTOR expression in cancer patients: a meta-analysis
Prognostic and clinicopathological significance of DEPTOR expression in cancer patients: a meta-analysis Open
Our meta-analysis suggested that despite the fact that DEPTOR could be overexpressed or downregulated in cancer patients, it might not be a potential marker to predict the prognosis of cancer patients.
View article: Association between Fas/FasL gene polymorphism and musculoskeletal degenerative diseases: a meta-analysis
Association between Fas/FasL gene polymorphism and musculoskeletal degenerative diseases: a meta-analysis Open
View article: Prognostic value of abnormally expressed long non-coding RNAs in patients with osteosarcoma: a meta-analysis
Prognostic value of abnormally expressed long non-coding RNAs in patients with osteosarcoma: a meta-analysis Open
// Fashuai Wu 1, * , Deyao Shi 1, * , Shidai Mu 2 , Yu Huang 3 , Feng Gao 1 , Xiangcheng Qing 1 and Zengwu Shao 1 1 Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 43…
View article: Prognostic Value of Programmed Cell Death 1 Ligand-1 (PD-L1) or PD-1 Expression in Patients with Osteosarcoma: A Meta-Analysis
Prognostic Value of Programmed Cell Death 1 Ligand-1 (PD-L1) or PD-1 Expression in Patients with Osteosarcoma: A Meta-Analysis Open
Purpose: Programmed cell death 1 ligand-1 (PD-L1) and PD-1 as prognostic biomarkers have spurred considerable interest in several types of malignant tumors. In the present meta-analysis, we aimed to elucidate the clinicopathological…
View article: Correction: Prognostic value of long non-coding RNA CCAT1 expression in patients with cancer: A meta-analysis
Correction: Prognostic value of long non-coding RNA CCAT1 expression in patients with cancer: A meta-analysis Open
[This corrects the article DOI: 10.1371/journal.pone.0179346.].
View article: Association of COL1A1 rs1800012 polymorphism with musculoskeletal degenerative diseases: a meta-analysis
Association of COL1A1 rs1800012 polymorphism with musculoskeletal degenerative diseases: a meta-analysis Open
It has been reported that the single nucleotide polymorphism (SNP) rs1800012 in COL1A1 gene might be linked to the susceptibility of musculoskeletal degenerative diseases, such as osteoarthritis (OA) and intervertebral disc degeneration (I…
View article: Prognostic value of long non-coding RNA CCAT1 expression in patients with cancer: A meta-analysis
Prognostic value of long non-coding RNA CCAT1 expression in patients with cancer: A meta-analysis Open
The meta-analysis results from present study suggested that increased expression level of CCAT1 was associated with poor prognosis and can serve as an independent biomarker. And the expression level of CCAT1 was associated with clinicopath…
View article: Mesenchymal Stem Cells Protect Nucleus Pulposus Cells from Compression-Induced Apoptosis by Inhibiting the Mitochondrial Pathway
Mesenchymal Stem Cells Protect Nucleus Pulposus Cells from Compression-Induced Apoptosis by Inhibiting the Mitochondrial Pathway Open
Objective . Excessive apoptosis of nucleus pulposus cells (NPCs) induced by various stresses, including compression, contributes to the development of intervertebral disc degeneration (IVDD). Mesenchymal stem cells (MSCs) can benefit the r…