Fatemah Basingab
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View article: Immunomodulatory Effects of Escherichia coli Phage GADS24 on Human Dendritic Cells
Immunomodulatory Effects of Escherichia coli Phage GADS24 on Human Dendritic Cells Open
Background: Multidrug-resistant (MDR) Escherichia coli (E. coli) strains pose a significant public health challenge, which has led to the exploration of alternative therapeutic strategies. Due to their antibacterial and immunomodulatory pr…
View article: Molecular Screening Reveals De Novo Loss-of-Function NR4A2 Variants in Saudi Children with Autism Spectrum Disorders: A Single-Center Study
Molecular Screening Reveals De Novo Loss-of-Function NR4A2 Variants in Saudi Children with Autism Spectrum Disorders: A Single-Center Study Open
Dysregulated expression of nuclear receptor superfamily 4 group A member 2 (NR4A2) has recently been associated with autistic spectrum disorder (ASD), speech impairment, and neurodevelopmental delay (NDD); however, its precise role in the …
View article: Impact of Chitosan Nanoparticles-Coated Dendritic Cell-Based Vaccine as Cancer Immunotherapy
Impact of Chitosan Nanoparticles-Coated Dendritic Cell-Based Vaccine as Cancer Immunotherapy Open
Dendritic cells (DCs) are major contributors to generating an effective immune response due to their ability to present antigens to T cells. Recently, nanoparticles have been widely used in different medical applications, such as drug-deli…
View article: The Immunohistochemical Prognostic Value of Nuclear and Cytoplasmic Silent Information Regulator 1 Protein Expression in Saudi Patients with Breast Cancer
The Immunohistochemical Prognostic Value of Nuclear and Cytoplasmic Silent Information Regulator 1 Protein Expression in Saudi Patients with Breast Cancer Open
Background: The mammalian NAD-dependent deacetylase sirtuin-1 family (named also silent information regulator or SIRT family, where NAD stands for “nicotinamide adenine dinucleotide” (NAD)) appears to have a dual role in several human canc…
View article: From Pioneering Discoveries to Innovative Therapies: A Journey Through the History and Advancements of Nanoparticles in Breast Cancer Treatment
From Pioneering Discoveries to Innovative Therapies: A Journey Through the History and Advancements of Nanoparticles in Breast Cancer Treatment Open
Nanoparticle technology has revolutionized breast cancer treatment by offering innovative solutions addressing the gaps in traditional treatment methods. This paper aimed to comprehensively explore the historical journey and advancements o…
View article: T-Cell Immunoglobulin and Mucin Domain 3 (TIM-3) Gene Expression as a Negative Biomarker of B-Cell Acute Lymphoblastic Leukemia
T-Cell Immunoglobulin and Mucin Domain 3 (TIM-3) Gene Expression as a Negative Biomarker of B-Cell Acute Lymphoblastic Leukemia Open
B-cell acute lymphoblastic leukemia (B-ALL) accounts for 85% of all childhood ALL. Malignancies exhaust T and B cells, resulting in an increased expression of immune checkpoint receptors (ICRs), such as T-cell immunoglobulin and mucin doma…
View article: Gut microbiota of children with autism spectrum disorder and healthy siblings: A comparative study
Gut microbiota of children with autism spectrum disorder and healthy siblings: A comparative study Open
Autism spectrum disorder (ASD) is a neurodevelopmental abnormality that impairs social communication. The human gut microbiome (GM) influences a variety of local processes, including dysbiosis and the defense against pathogenic microorgani…
View article: Synthesis of silver nanoparticles embedded into melamine polyaminal networks as antibacterial and anticancer active agents
Synthesis of silver nanoparticles embedded into melamine polyaminal networks as antibacterial and anticancer active agents Open
View article: Newcastle Disease Virus Virotherapy: Unveiling Oncolytic Efficacy and Immunomodulation
Newcastle Disease Virus Virotherapy: Unveiling Oncolytic Efficacy and Immunomodulation Open
In virotherapy, cancer cells are eradicated via viral infection, replication, and dissemination (oncolysis). Background: This study aims to evaluate the oncolytic potential of Newcastle disease virus (NDV) against colon cancer and explore …
View article: Copy number variations in autistic children
Copy number variations in autistic children Open
Autism spectrum disorder (ASD) manifests as a neurodevelopmental condition marked by challenges in social communication, interaction and the performing of repetitive behaviors. The prevalence of autism increases markedly on an annual basis…
View article: Herpesvirus Entry Mediator as an Immune Checkpoint Target and a Potential Prognostic Biomarker in Myeloid and Lymphoid Leukemia
Herpesvirus Entry Mediator as an Immune Checkpoint Target and a Potential Prognostic Biomarker in Myeloid and Lymphoid Leukemia Open
Herpesvirus entry mediator (HVEM) is a molecular switch that can modulate immune responses against cancer. The significance of HVEM as an immune checkpoint target and a potential prognostic biomarker in malignancies is still controversial.…
View article: Gut microbiota composition in patients with Crohn’s disease in Saudi Arabia
Gut microbiota composition in patients with Crohn’s disease in Saudi Arabia Open
Crohn’s disease (CD) entails intricate interactions with gut microbiome diversity, richness, and composition. The relationship between CD and gut microbiome is not clearly understood and has not been previously characterized in Saudi Arabi…
View article: Interaction between Gut Microbiota and Dendritic Cells in Colorectal Cancer
Interaction between Gut Microbiota and Dendritic Cells in Colorectal Cancer Open
Colorectal cancer (CRC) is a malignancy that manifests in serial stages and has been observed to have an escalating incidence in modern societies, causing a significant global health problem. The development of CRC is influenced by various…
View article: Optimizing the generation of mature bone marrow-derived dendritic cells in vitro: a factorial study design
Optimizing the generation of mature bone marrow-derived dendritic cells in vitro: a factorial study design Open
The analysis of this study indicates a substantial interaction between cytokines combinations and cell densities on BMDC maturation. However, higher cell density is not associated with optimizing DC maturation. Notably, applying DoE in bio…
View article: Herpesvirus entry mediator as a potential biomarker in breast cancer compared with conventional cytotoxic T‑lymphocyte‑associated antigen 4
Herpesvirus entry mediator as a potential biomarker in breast cancer compared with conventional cytotoxic T‑lymphocyte‑associated antigen 4 Open
Breast cancer (BC) is the most common cancer in women worldwide, with 2.3 million cases recorded in 2020. Despite improvements in cancer treatment, patients with BC still succumb to the disease, due to regional and distant metastases when …
View article: Gender Differences in Response to COVID-19 Infection and Vaccination
Gender Differences in Response to COVID-19 Infection and Vaccination Open
Since COVID-19 first appeared, a number of follow-up events have taken place. In an effort to find a solution to this catastrophe, a great deal of study and analysis has been conducted. Because of the high morbidity and exceptionally large…
View article: Legend for Supplementary Figure 1 from IFNγ-Dependent Interactions between ICAM-1 and LFA-1 Counteract Prostaglandin E2–Mediated Inhibition of Antitumor CTL Responses
Legend for Supplementary Figure 1 from IFNγ-Dependent Interactions between ICAM-1 and LFA-1 Counteract Prostaglandin E2–Mediated Inhibition of Antitumor CTL Responses Open
Legend for Supplementary Figure 1
View article: Data from IFNγ-Dependent Interactions between ICAM-1 and LFA-1 Counteract Prostaglandin E2–Mediated Inhibition of Antitumor CTL Responses
Data from IFNγ-Dependent Interactions between ICAM-1 and LFA-1 Counteract Prostaglandin E2–Mediated Inhibition of Antitumor CTL Responses Open
Tumor-expressed ICAM-1 interaction with LFA-1 on naïve tumor-specific CD8+ T cells not only stabilizes adhesion, but, in the absence of classical B7-mediated costimulation, is also able to provide potent alternative costimulator…
View article: Data from IFNγ-Dependent Interactions between ICAM-1 and LFA-1 Counteract Prostaglandin E2–Mediated Inhibition of Antitumor CTL Responses
Data from IFNγ-Dependent Interactions between ICAM-1 and LFA-1 Counteract Prostaglandin E2–Mediated Inhibition of Antitumor CTL Responses Open
Tumor-expressed ICAM-1 interaction with LFA-1 on naïve tumor-specific CD8+ T cells not only stabilizes adhesion, but, in the absence of classical B7-mediated costimulation, is also able to provide potent alternative costimulator…
View article: Supplementary Figure 1 from IFNγ-Dependent Interactions between ICAM-1 and LFA-1 Counteract Prostaglandin E2–Mediated Inhibition of Antitumor CTL Responses
Supplementary Figure 1 from IFNγ-Dependent Interactions between ICAM-1 and LFA-1 Counteract Prostaglandin E2–Mediated Inhibition of Antitumor CTL Responses Open
ICAM-1-LFA-1 interactions reverse the effect of PGE2 on CL4 CD8+ T cell proliferation.
View article: Supplementary Figure 1 from IFNγ-Dependent Interactions between ICAM-1 and LFA-1 Counteract Prostaglandin E2–Mediated Inhibition of Antitumor CTL Responses
Supplementary Figure 1 from IFNγ-Dependent Interactions between ICAM-1 and LFA-1 Counteract Prostaglandin E2–Mediated Inhibition of Antitumor CTL Responses Open
ICAM-1-LFA-1 interactions reverse the effect of PGE2 on CL4 CD8+ T cell proliferation.
View article: Legend for Supplementary Figure 1 from IFNγ-Dependent Interactions between ICAM-1 and LFA-1 Counteract Prostaglandin E2–Mediated Inhibition of Antitumor CTL Responses
Legend for Supplementary Figure 1 from IFNγ-Dependent Interactions between ICAM-1 and LFA-1 Counteract Prostaglandin E2–Mediated Inhibition of Antitumor CTL Responses Open
Legend for Supplementary Figure 1
View article: DNA Methylation Level of Transcription Factor Binding Site in the Promoter Region of Acyl-CoA Synthetase Family Member 3 (ACSF3) in Saudi Autistic Children [Corrigendum]
DNA Methylation Level of Transcription Factor Binding Site in the Promoter Region of Acyl-CoA Synthetase Family Member 3 (ACSF3) in Saudi Autistic Children [Corrigendum] Open
[This corrects the article DOI: 10.2147/PGPM.S346187.].
View article: Tumor necrosis factor alpha and lipopolysaccharides synergistic effects on T-cell immunoglobulin and mucin domain 3 regulation in dendritic cells
Tumor necrosis factor alpha and lipopolysaccharides synergistic effects on T-cell immunoglobulin and mucin domain 3 regulation in dendritic cells Open
Background and objectives: Mature dendritic cells (DCs) are essential inducers of anti-tumor immunity. However, the inflammatory tumor microenvironment (TME) develops tumor associated DCs (TADCs) that adopt different immunosuppressive mech…
View article: Multiple Recurrent Copy Number Variations (CNVs) in Chromosome 22 Including 22q11.2 Associated with Autism Spectrum Disorder
Multiple Recurrent Copy Number Variations (CNVs) in Chromosome 22 Including 22q11.2 Associated with Autism Spectrum Disorder Open
CNV deletion and the duplication of the TBX1 gene could be related to ASD; therefore, this gene needs more analysis in terms of expression levels.
View article: Biodegradation Potential of Phenol and Toluene by Marine Staphylococcus pasteuri Isolated from the Red Sea, Saudi Arabia
Biodegradation Potential of Phenol and Toluene by Marine Staphylococcus pasteuri Isolated from the Red Sea, Saudi Arabia Open
Hydrocarbons including phenol and toluene are considered as the major source of energy and raw material of different industrial products. Although toluene and phenol have various beneficial applications, many studies reported the massive n…
View article: Alterations in Immune-Related Defensin Alpha 4 (DEFA4) Gene Expression in Health and Disease
Alterations in Immune-Related Defensin Alpha 4 (DEFA4) Gene Expression in Health and Disease Open
Defensin Alpha 4 (DEFA4) is the fourth member of the Alpha Defensins family known as a part of antimicrobial peptides in the innate immune system. DEFA4 has a strong preference to kill Gram-negative bacteria more than Gram-positive bacteri…
View article: The Role of Alpha-1-acid Glycoprotein 2 Protein and the Underlying Orosomucoid 2 Gene in Different Diseases
The Role of Alpha-1-acid Glycoprotein 2 Protein and the Underlying Orosomucoid 2 Gene in Different Diseases Open
Alpha-1-Acid glycoprotein 2 (AGP2) or orosomucoid 2 (ORM2) is a major plasma protein. AGP2 is a member of the immunocalin family, a lipocalin subfamily expressed mainly in hepatocytes and also in astrocytes and endothelial cells. The detai…
View article: DNA Methylation Level of Transcription Factor Binding Site in the Promoter Region of Acyl-CoA Synthetase Family Member 3 (ACSF3) in Saudi Autistic Children
DNA Methylation Level of Transcription Factor Binding Site in the Promoter Region of Acyl-CoA Synthetase Family Member 3 (ACSF3) in Saudi Autistic Children Open
Khloud Algothmi,1 Amal Alqurashi,1 Aisha Alrofaidi,1 Mona Alharbi,1 Reem Farsi,1 Najla Alburae,1 Magdah Ganash,1 Sheren Azhari,1 Fatemah Basingab,1 Asma Almuhammadi,1 Amany Alqosaibi,2 Heba Alkhatabi,3,4 Aisha Elaimi,3,4 Mohammed Jan,5 Hes…
View article: Investigating the Changing Levels of Immune Checkpoint Proteins in The Serum of Breast Cancer Patients
Investigating the Changing Levels of Immune Checkpoint Proteins in The Serum of Breast Cancer Patients Open
Breast cancer is the most frequent kind of invasive cancer in women. Biomarker monitoring and prognosis provide outstanding clinical information that may be employed to battle various cancers. This study aimed to examine a variety of bioma…