Fatemeh Abbaszadeh
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View article: Deciphering the effects of polydatin on neuropathic pain and motor performance in a chronic constriction injury model: role of GABA and opioid receptors and neuroprotective properties
Deciphering the effects of polydatin on neuropathic pain and motor performance in a chronic constriction injury model: role of GABA and opioid receptors and neuroprotective properties Open
Background Chronic nerve pain is a complex and debilitating condition. Considering the complex pathophysiology of chronic nerve pain, researchers aim to develop novel multi-targeting agents. Polydatin (PLD), a natural multi-targeting compo…
View article: Polydatin Relieves Nociceptive Pain: Possible Role of L-arginine/NO/cGMP/K<sub>ATP</sub> Channel Signaling Pathway in Mice
Polydatin Relieves Nociceptive Pain: Possible Role of L-arginine/NO/cGMP/K<sub>ATP</sub> Channel Signaling Pathway in Mice Open
Background: The role of the L-arginine (L-Arg)/nitric oxide (NO)/cyclic GMP (cGMP)/ATP-sensitive potassium channel (KATP) channel pathway in pain regulation is well-known. Previous studies have confirmed the pain-relieving effects of polyd…
View article: Role of autophagy in neurotoxic protein’s clearance following post-ischemic stroke: where we are and what we know?
Role of autophagy in neurotoxic protein’s clearance following post-ischemic stroke: where we are and what we know? Open
BACKGROUND: The role of autophagy following stroke and its underlying cascades have not yet been investigated in detail. The ischemic brain is characterized by complex pathophysiological mechanisms, including increased excitotoxicity, oxid…
View article: Neurovascular Mediators and Psychological Symptoms in Systemic Sclerosis: A Cross-sectional Study
Neurovascular Mediators and Psychological Symptoms in Systemic Sclerosis: A Cross-sectional Study Open
Introduction Recent research has demonstrated the role of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in both systemic sclerosis (SSc) and other neurological disorders. These molecules are central to ne…
View article: Exploring the neuroprotective potential of naringin following spinal cord injury in rats: improving sensory and motor function through combating inflammation and oxidative stress
Exploring the neuroprotective potential of naringin following spinal cord injury in rats: improving sensory and motor function through combating inflammation and oxidative stress Open
Introduction Spinal cord injury (SCI) leads to widespread cascades of inflammatory and oxidative factors. This pathological condition damages nerves and causes neurological disorders. To address these complex conditions, it is important to…
View article: Pelargonidin improves functional recovery and attenuates neuropathic pain following spinal cord injury in rats: relevance to its neuroprotective, antioxidant, and anti-inflammatory effects
Pelargonidin improves functional recovery and attenuates neuropathic pain following spinal cord injury in rats: relevance to its neuroprotective, antioxidant, and anti-inflammatory effects Open
Background Spinal cord injury (SCI) significantly impairs individuals’ sensorimotor functions, hindering daily activities. Current therapeutic options often demonstrate limited efficacy and lead to undesirable side effects. Emerging resear…
View article: Unveiling the effects of Rosa canina oligosaccharide liposome on neuropathic pain and motor dysfunction following spinal cord injury in rats: relevance to its antioxidative effects
Unveiling the effects of Rosa canina oligosaccharide liposome on neuropathic pain and motor dysfunction following spinal cord injury in rats: relevance to its antioxidative effects Open
Background Spinal cord injury (SCI) is a leading cause of sensorimotor disorders, impacting millions of people globally. The absence of effective treatments and the side effects of existing medications highlight the need for innovative res…
View article: Serum TLR2 and S100B in Substance Abuse: A Clinical Perspective
Serum TLR2 and S100B in Substance Abuse: A Clinical Perspective Open
Background: Substance abuse leads to blood-brain barrier dysfunction and activation of neuro-inflammatory pathways. However, the contribution of serum levels of Toll-like receptor 2 (TLR-2) and S100 calcium-binding protein B (S100B) to neu…
View article: Anti-neuropathic effects of astaxanthin in a rat model of chronic constriction injury: passing through opioid/benzodiazepine receptors and relevance to its antioxidant and anti-inflammatory effects
Anti-neuropathic effects of astaxanthin in a rat model of chronic constriction injury: passing through opioid/benzodiazepine receptors and relevance to its antioxidant and anti-inflammatory effects Open
Introduction Neuropathic pain is a debilitating neurological disorder and is on the rise. Since no effective treatment has been so far approved to combat the complex pathological mechanisms behind neuropathic pain, finding new therapeutic …
View article: Polydatin attenuated neuropathic pain and motor dysfunction following spinal cord injury in rats by employing its anti-inflammatory and antioxidant effects
Polydatin attenuated neuropathic pain and motor dysfunction following spinal cord injury in rats by employing its anti-inflammatory and antioxidant effects Open
Background Considering the complex pathological mechanisms behind spinal cord injury (SCI) and the adverse effects of present non-approved drugs against SCI, new studies are needed to introduce novel multi-target active ingredients with hi…
View article: Intranasal CEPO-FC prevents attention deficits in streptozotocin-induced rat model of Alzheimer's disease: Focus on synaptic plasticity-related factors
Intranasal CEPO-FC prevents attention deficits in streptozotocin-induced rat model of Alzheimer's disease: Focus on synaptic plasticity-related factors Open
Alzheimer's disease remains an issue of great controversy due to its pathology. It is characterized by cognitive impairments and neuropsychiatric symptoms. The FDA approved medications for this disease, can only mitigate the symptoms. One …
View article: Intrathecal administration of naringenin improves motor dysfunction and neuropathic pain following compression spinal cord injury in rats: relevance to its antioxidant and anti-inflammatory activities
Intrathecal administration of naringenin improves motor dysfunction and neuropathic pain following compression spinal cord injury in rats: relevance to its antioxidant and anti-inflammatory activities Open
BACKGROUND: Spinal cord injury (SCI) is one of the most debilitating disorders throughout the world, causing persistent sensory-motor dysfunction, with no effective treatment. Oxidative stress and inflammatory responses play key roles in t…
View article: Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury
Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury Open
Despite the progression in targeting the complex pathophysiological mechanisms of neurodegenerative diseases (NDDs) and spinal cord injury (SCI), there is a lack of effective treatments. Moreover, conventional therapies suffer from associa…
View article: Sex influence on sensory responses following spinothalamic tract injury in rats
Sex influence on sensory responses following spinothalamic tract injury in rats Open
View article: On the therapeutic targets and pharmacological treatments for pain relief following spinal cord injury: A mechanistic review
On the therapeutic targets and pharmacological treatments for pain relief following spinal cord injury: A mechanistic review Open
Spinal cord injury (SCI) is globally considered as one of the most debilitating disorders, which interferes with daily activities and life of the affected patients. Despite many developments in related recognizing and treating procedures, …
View article: The effects of intrathecal ketamine on improving sensory-motor function in a rat model of compression spinal cord injury
The effects of intrathecal ketamine on improving sensory-motor function in a rat model of compression spinal cord injury Open
The effects of intrathecal ketamine on improving sensory-motor function in a rat model of compression spinal cord injury
View article: Sex Differences and Role of Gonadal Hormones on Glutamate Level, After Spinal Cord Injury in Rats: A Microdialysis Study
Sex Differences and Role of Gonadal Hormones on Glutamate Level, After Spinal Cord Injury in Rats: A Microdialysis Study Open
The significant differences in glutamate levels between both intact and gonadectomized SCI male and female rats show the sex-hormone-related mechanisms underlying the molecular events in the second phase of SCI. It seems that the role of m…