Fatih Alioglu
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View article: Accelerated Endosomal Escape of Splice-Switching Oligonucleotides Enables Efficient Hepatic Splice Correction
Accelerated Endosomal Escape of Splice-Switching Oligonucleotides Enables Efficient Hepatic Splice Correction Open
Splice-switching oligonucleotides (SSOs) can restore protein functionality in pathologies and are promising tools for manipulating the RNA-splicing machinery. Delivery vectors can considerably improve SSO functionality in vivo and allow do…
View article: Investigating 3R In Vivo Approaches for Bio‐Distribution and Efficacy Evaluation of Nucleic Acid Nanocarriers: Studies on Peptide‐Mimicking Ionizable Lipid
Investigating 3R In Vivo Approaches for Bio‐Distribution and Efficacy Evaluation of Nucleic Acid Nanocarriers: Studies on Peptide‐Mimicking Ionizable Lipid Open
Formulations based on ionizable amino‐lipids have been put into focus as nucleic acid delivery systems. Recently, the in vitro efficacy of the lipid formulation OH4:DOPE has been explored. However, in vitro performance of nanomedicines can…
View article: Peptide-Targeted Polyplexes for Aerosol-Mediated Gene Delivery to CD49f-Overexpressing Tumor Lesions in Lung
Peptide-Targeted Polyplexes for Aerosol-Mediated Gene Delivery to CD49f-Overexpressing Tumor Lesions in Lung Open
Peptide ligands can enhance delivery of nucleic acid-loaded nanoparticles to tumors by promoting their cell binding and internalization. Lung tumor lesions accessible from the alveolar side can be transfected, in principle, using gene vect…
View article: Bacterial ghosts as adjuvant to oxaliplatin chemotherapy in colorectal carcinomatosis
Bacterial ghosts as adjuvant to oxaliplatin chemotherapy in colorectal carcinomatosis Open
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and a major cause of cancer mortality worldwide. At late stage of the disease CRC often shows (multiple) metastatic lesions in the peritoneal cavity which cannot be effi…