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View article: HDL-associated phosphatidylserine blunts myeloid activation and protects from atherosclerosis
HDL-associated phosphatidylserine blunts myeloid activation and protects from atherosclerosis Open
Background and aims Lipids play a critical role in atherosclerosis. Low-density lipoprotein (LDL)-cholesterol and certain lipid classes like sphingomyelins are associated with inflammation and poor cardiovascular outcomes. Phosphatidylseri…
View article: Circadian Control of Neutrophils Drives Collateral Perfusion and Stroke Outcome
Circadian Control of Neutrophils Drives Collateral Perfusion and Stroke Outcome Open
BACKGROUND: Stroke remains a leading cause of mortality and disability, driven by complex, time-dependent mechanisms that aggravate ischemic injury. Collateral perfusion dictates infarct size, expansion rate, and penumbral preservation, ye…
View article: Pharmacogenomics and chronotherapy of drug-induced cardioprotection in acute myocardial infarction
Pharmacogenomics and chronotherapy of drug-induced cardioprotection in acute myocardial infarction Open
Acute myocardial infarction remains a leading cause of morbidity and mortality worldwide. Pharmacogenetic and chronotherapeutic approaches are increasingly applied to optimize therapy in chronic cardiovascular diseases. While gene variants…
View article: Atherosclerotic disease activity is associated with glycolytic enzyme expression across multiple cell types and is trackable by FDG-PET
Atherosclerotic disease activity is associated with glycolytic enzyme expression across multiple cell types and is trackable by FDG-PET Open
Positron emission tomography (PET) imaging with the radiolabeled glucose analog fluorodeoxyglucose ( 18 FDG) is used to monitor atherosclerosis in clinical trials, but there is uncertainty regarding the plaque cell types that accumulate FD…
View article: Lamin A/C Expression in Hematopoietic Cells Declines During Human Aging and Constrains Atherosclerosis in Mice
Lamin A/C Expression in Hematopoietic Cells Declines During Human Aging and Constrains Atherosclerosis in Mice Open
BACKGROUND: Aging is the primary risk factor for atherosclerosis, a degenerative process regulated by immune cells and the leading cause of death worldwide. Previous studies on premature aging syndromes have linked atherosclerosis to defec…
View article: Exploration of fecal microbiota in newly diagnosed patients with inflammatory bowel disease using shotgun metagenomics
Exploration of fecal microbiota in newly diagnosed patients with inflammatory bowel disease using shotgun metagenomics Open
Introduction Dysbiosis is a key mechanism in inflammatory bowel disease (IBD) pathophysiology. Previous microbiota studies in IBD generally have involved patients treated with immunosuppressive agents, which can affect the results. We aime…
View article: Titin cleavage is a driver of cardiomyocyte disengagement and reactive myocardial fibrosis
Titin cleavage is a driver of cardiomyocyte disengagement and reactive myocardial fibrosis Open
Myocardial remodeling including cardiomyocyte-death-independent, reactive fibrosis and disconnection of cardiomyocytes is at the basis of prevalent cardiac conditions converging into arrhythmias and heart failure. However, the molecular me…
View article: Long-Term Elite Controllers of HIV-1 Infection Exhibit a Deep Perturbation of Monocyte Homeostasis
Long-Term Elite Controllers of HIV-1 Infection Exhibit a Deep Perturbation of Monocyte Homeostasis Open
Elite controllers (ECs) represent a unique subset of people living with HIV (PLWHs), who can suppress viral replication without requiring antiretroviral therapy (ART). However, despite this viral control, ECs exhibit increased incidences o…
View article: A Survey for Human Tissue-Level Determinants of CAV1 Regulation and Function
A Survey for Human Tissue-Level Determinants of CAV1 Regulation and Function Open
CAV1 is a protein-coding gene linked to several disorders, including cancer, lipodystrophy, and cardiovascular diseases. While its ability to respond to various mechanical and metabolic stimuli has been documented, a comprehensive understa…
View article: Circadian Modulation of Neutrophil Function Determines Collateral Perfusion and Outcome After Ischemic Stroke
Circadian Modulation of Neutrophil Function Determines Collateral Perfusion and Outcome After Ischemic Stroke Open
Stroke is a leading cause of mortality and disability, driven by complex and time-dependent mechanisms that aggravate ischemic damage. Among them, collateral perfusion determines the initial size of the ischemic core, the rate of its expan…
View article: Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow
Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow Open
Impairment of the intestinal barrier allows the systemic translocation of commensal bacteria, inducing a proinflammatory state in the host. Here, we investigated innate immune responses following increased gut permeability upon administrat…
View article: Translocation of gut<i>Enterococcus faecalis</i>trains myeloid bone marrow progenitors via the C-type lectin receptor Mincle
Translocation of gut<i>Enterococcus faecalis</i>trains myeloid bone marrow progenitors via the C-type lectin receptor Mincle Open
Summary Impairment of the intestinal barrier allows the systemic translocation of commensal bacteria, inducing a pro-inflammatory state in the host. To address potential mechanisms underlying this link, we explored innate immune responses …
View article: Endothelial YAP/TAZ activation promotes atherosclerosis in a mouse model of Hutchinson-Gilford progeria syndrome
Endothelial YAP/TAZ activation promotes atherosclerosis in a mouse model of Hutchinson-Gilford progeria syndrome Open
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare disease caused by the expression of progerin, an aberrant protein produced by a point mutation in the LMNA gene. HGPS patients show accelerated aging and die prematurely main…
View article: Unidirectional association of clonal hematopoiesis with atherosclerosis development
Unidirectional association of clonal hematopoiesis with atherosclerosis development Open
Clonal hematopoiesis, a condition in which acquired somatic mutations in hematopoietic stem cells lead to the outgrowth of a mutant hematopoietic clone, is associated with a higher risk of hematological cancer and a growing list of nonhema…
View article: Endothelial-to-Mesenchymal Transition Contributes to Accelerated Atherosclerosis in Hutchinson-Gilford Progeria Syndrome
Endothelial-to-Mesenchymal Transition Contributes to Accelerated Atherosclerosis in Hutchinson-Gilford Progeria Syndrome Open
BACKGROUND: Atherosclerosis is the main medical problem in Hutchinson-Gilford progeria syndrome, a rare premature aging disorder caused by the mutant lamin-A protein progerin. Recently, we found that limiting progerin expression to vascula…
View article: Single‐cell <scp>RNA</scp> sequencing of human blood eosinophils reveals plasticity and absence of canonical cell subsets
Single‐cell <span>RNA</span> sequencing of human blood eosinophils reveals plasticity and absence of canonical cell subsets Open
Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAM
View article: T Cell Homeostasis Disturbances in a Cohort of Long-Term Elite Controllers of HIV Infection
T Cell Homeostasis Disturbances in a Cohort of Long-Term Elite Controllers of HIV Infection Open
Elite controllers (ECs) are people living with HIV (PLWH) able to control HIV replication without antiretroviral therapy and have been proposed as a model of a functional HIV cure. Much evidence suggests that this spontaneous control of HI…
View article: A specific natural killer cells phenotypic signature associated to long term elite control of HIV infection
A specific natural killer cells phenotypic signature associated to long term elite control of HIV infection Open
Elite controllers (ECs) are an exceptional group of people living with HIV (PLWH) that control HIV replication without therapy. Among the mechanisms involved in this ability, natural killer (NK)‐cells have recently gained much attention. W…
View article: Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy
Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy Open
Myosin inhibitor mavacamten is the only targeted treatment available for hypertrophic cardiomyopathy (HCM), a disease caused by hundreds of genetic variants that affect mainly sarcomeric myosin and its negative regulator cardiac myosin-bin…
View article: SpatialDDLS: an R package to deconvolute spatial transcriptomics data using neural networks
SpatialDDLS: an R package to deconvolute spatial transcriptomics data using neural networks Open
Summary Spatial transcriptomics has changed our way to study tissue structure and cellular organization. However, there are still limitations in its resolution, and most available platforms do not reach a single cell resolution. To address…
View article: Apolipoprotein E-ε2 and Resistance to Atherosclerosis in Midlife: The PESA Observational Study
Apolipoprotein E-ε2 and Resistance to Atherosclerosis in Midlife: The PESA Observational Study Open
BACKGROUND: APOE is a known genetic contributor to cardiovascular disease, but the differential role APOE alleles play in subclinical atherosclerosis remains unclear. METHODS: The PESA (Progression of Early Subclinical Atherosclerosis) is …
View article: Epigenetic priming of embryonic lineages in the mammalian epiblast
Epigenetic priming of embryonic lineages in the mammalian epiblast Open
Summary Understanding the diversification of mammalian cell lineages is an essential to embryonic development, organ regeneration and tissue engineering. Shortly after implantation in the uterus, the pluripotent cells of the mammalian epib…
View article: P010 Faecal microbiota composition by shotgun metagenomic sequencing approach in a newly diagnosed cohort of inflammatory bowel disease patients: results from the IBDomics project
P010 Faecal microbiota composition by shotgun metagenomic sequencing approach in a newly diagnosed cohort of inflammatory bowel disease patients: results from the IBDomics project Open
Background Most studies examining differences in gut microbiota composition between healthy individuals and inflammatory bowel disease (IBD) patients, have been conducted on patients receiving immunosuppressive therapy. Such treatments can…