Fatimah K. Khalaf
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View article: Pulsed Wave Mode of Fractional Radiofrequency Microneedling as a New Advance in the Treatment of Inflammatory Acne Vulgaris
Pulsed Wave Mode of Fractional Radiofrequency Microneedling as a New Advance in the Treatment of Inflammatory Acne Vulgaris Open
Inflammatory acne vulgaris (IAV) is a common skin condition characterized by the presence of reddish, inflamed, and painful lesions on the skin. IAV can drastically affect individuals, specifically their self-esteem, psychological health, …
View article: Aerosolized Harmful Algal Bloom Toxin Microcystin-LR Induces Type 1/Type 17 Inflammation of Murine Airways
Aerosolized Harmful Algal Bloom Toxin Microcystin-LR Induces Type 1/Type 17 Inflammation of Murine Airways Open
Harmful algal blooms are increasing globally and pose serious health concerns releasing cyanotoxins. Microcystin-LR (MC-LR), one of the most frequently produced cyanotoxins, has recently been detected in aerosols generated by the normal mo…
View article: Paraoxonases at the Heart of Neurological Disorders
Paraoxonases at the Heart of Neurological Disorders Open
Paraoxonase enzymes serve as an important physiological redox system that participates in the protection against cellular injury caused by oxidative stress. The PON enzymes family consists of three members (PON-1, PON-2, and PON-3) that sh…
View article: Microcystin-LR aerosol induces inflammatory responses in healthy human primary airway epithelium
Microcystin-LR aerosol induces inflammatory responses in healthy human primary airway epithelium Open
Harmful algal blooms plague bodies of freshwater globally. These blooms are often composed of outgrowths of cyanobacteria capable of producing the heptapeptide Microcystin-LR (MC-LR) which is a well-known hepatotoxin. Recently, MC-LR has b…
View article: Evaluating the Roles of Different Types of Laser Therapy in Becker’s Nevus Treatment
Evaluating the Roles of Different Types of Laser Therapy in Becker’s Nevus Treatment Open
Becker’s nevus (BN) is a cutaneous hamartoma of benign nature that develops through adolescence and affects mostly young men. The nevus is usually located unilaterally and is characterized by hypertrichosis and hyperpigmentation. Despite r…
View article: Paraoxonase-1 Regulation of Renal Inflammation and Fibrosis in Chronic Kidney Disease
Paraoxonase-1 Regulation of Renal Inflammation and Fibrosis in Chronic Kidney Disease Open
Papraoxonase-1 (PON1) is a hydrolytic lactonase enzyme that is synthesized in the liver and circulates attached to high-density lipoproteins (HDL). Clinical studies have demonstrated an association between diminished PON-1 and the progress…
View article: A PON for All Seasons: Comparing Paraoxonase Enzyme Substrates, Activity and Action including the Role of PON3 in Health and Disease
A PON for All Seasons: Comparing Paraoxonase Enzyme Substrates, Activity and Action including the Role of PON3 in Health and Disease Open
Paraoxonases (PONs) are a family of hydrolytic enzymes consisting of three members, PON1, PON2, and PON3, located on human chromosome 7. Identifying the physiological substrates of these enzymes is necessary for the elucidation of their bi…
View article: Getting to the Heart and Soul of Chronic Kidney Disease
Getting to the Heart and Soul of Chronic Kidney Disease Open
View article: Renal Fibrosis Is Significantly Attenuated Following Targeted Disruption of <i>Cd40</i> in Experimental Renal Ischemia
Renal Fibrosis Is Significantly Attenuated Following Targeted Disruption of <i>Cd40</i> in Experimental Renal Ischemia Open
Background Renal artery stenosis is a common cause of renal ischemia, contributing to the development of chronic kidney disease. To investigate the role of local CD 40 expression in renal artery stenosis, Goldblatt 2‐kidney 1‐clip surgery …
View article: Epithelial and Endothelial Adhesion of Immune Cells Is Enhanced by Cardiotonic Steroid Signaling Through Na <sup>+</sup> /K <sup>+</sup> ‐ATPase‐α‐1
Epithelial and Endothelial Adhesion of Immune Cells Is Enhanced by Cardiotonic Steroid Signaling Through Na <sup>+</sup> /K <sup>+</sup> ‐ATPase‐α‐1 Open
Background Recent studies have highlighted a critical role for a group of natriuretic hormones, cardiotonic steroid ( CTS ), in mediating renal inflammation and fibrosis associated with volume expanded settings, such as chronic kidney dise…
View article: Proinflammatory Effects of Cardiotonic Steroids Mediated by NKA α-1 (Na+/K+-ATPase α-1)/Src Complex in Renal Epithelial Cells and Immune Cells
Proinflammatory Effects of Cardiotonic Steroids Mediated by NKA α-1 (Na+/K+-ATPase α-1)/Src Complex in Renal Epithelial Cells and Immune Cells Open
Cardiotonic steroids (CTSs) are NKA α-1 (Na + /K + -ATPase α-1) ligands that are increased in volume expanded states and associated with cardiac and renal diseases. Although initiation and resolution of inflammation is an important compone…