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View article: Fatty Acid Profiling and Thymoquinone Quantification of Cold-Pressed Oils from Turkish- and Syrian-Originated Nigella sativa Seeds
Fatty Acid Profiling and Thymoquinone Quantification of Cold-Pressed Oils from Turkish- and Syrian-Originated Nigella sativa Seeds Open
Nigella sativa L. (black cumin) is an annual herb of the Ranunculaceae family, traditionally used in Middle Eastern and Asian medicine for the management of various health conditions. Its seeds and oils are rich in bioactive compounds, inc…
View article: 3-Hydroxytyrosol as a phenolic cholinesterase inhibitor with antiamnesic activity: a multimethodological study of selected plant phenolics
3-Hydroxytyrosol as a phenolic cholinesterase inhibitor with antiamnesic activity: a multimethodological study of selected plant phenolics Open
Background Plant phenolics are increasingly being investigated for their diverse biological activities, including neuroprotective effects relevant to conditions like Alzheimer’s disease. Objective The neurobiological potential of 37 plant …
View article: Evaluation of Enzyme Inhibitory Effects and Phytochemical Analysis by LC-Q-ToF MS of Some Polygonum L. Species Growing in Türkiye
Evaluation of Enzyme Inhibitory Effects and Phytochemical Analysis by LC-Q-ToF MS of Some Polygonum L. Species Growing in Türkiye Open
Polygonum species have strong biological activity due to their important bioactive components. Polygonum species have been studied for enzyme inhibition activity, wound healing, anti-inflammatory, antibacterial, antiviral, antioxidant effe…
View article: From Ethnopharmacology to Active Compound: Effects of Traditional Plant Extracts on Varicose Vein-Related Enzymes and Isolation of Active Flavonoids from Helichrysum plicatum DC. subsp. plicatum
From Ethnopharmacology to Active Compound: Effects of Traditional Plant Extracts on Varicose Vein-Related Enzymes and Isolation of Active Flavonoids from Helichrysum plicatum DC. subsp. plicatum Open
Background: Varicose veins and chronic venous insufficiency are chronic venous disorders involving abnormalities in the venous system. Inflammation, an increase in proteolytic enzymes, and free radicals are important factors that play a ro…
View article: Investigating COX-2 and 5-LOX Enzyme-Related Anti-Inflammatory and Antioxidant Activities and Phytochemical Features of Scutellaria salviifolia Benth
Investigating COX-2 and 5-LOX Enzyme-Related Anti-Inflammatory and Antioxidant Activities and Phytochemical Features of Scutellaria salviifolia Benth Open
Scutellaria species are widely utilized and have demonstrated diverse biological effects for various diseases, both globally and in traditional Chinese medicine, due to the presence of bioactive compounds with unique structures. This study…
View article: Evaluation of the Anti-Aging Properties of Ethanolic Extracts from Selected Plant Species and Propolis by Enzyme Inhibition Assays and 2D/3D Cell Culture Methods
Evaluation of the Anti-Aging Properties of Ethanolic Extracts from Selected Plant Species and Propolis by Enzyme Inhibition Assays and 2D/3D Cell Culture Methods Open
Background: Skin aging is a complex biological process affected by internal and external factors that disrupt the skin structure, especially in sun-exposed areas. Elastin and collagen in the dermis layer, responsible for the skin’s resista…
View article: Chromatographic Analysis and Enzyme Inhibition Potential of Reynoutria japonica Houtt.: Computational Docking, ADME, Pharmacokinetic, and Toxicokinetic Analyses of the Major Compounds
Chromatographic Analysis and Enzyme Inhibition Potential of Reynoutria japonica Houtt.: Computational Docking, ADME, Pharmacokinetic, and Toxicokinetic Analyses of the Major Compounds Open
Background: Reynoutria japonica Houtt. has been used for inflammatory diseases, skin burns, and high cholesterol in traditional Chinese medicine, and the roots and rhizomes of the plant were registered in the Chinese Pharmacopoeia. This st…
View article: Assessment of the Anti-Acne Properties of Some Medicinal Plants and Development of an Herbal Anti-Acne Formulation
Assessment of the Anti-Acne Properties of Some Medicinal Plants and Development of an Herbal Anti-Acne Formulation Open
Background: Acne is a prevalent dermatological condition characterized by the blockage of hair follicles and sebaceous glands, leading to the formation of acne. The anaerobe pathogen Cutibacterium acnes (formerly known as Propionibacterium…
View article: Evaluation of Selected Plant Phenolics via Beta-Secretase-1 Inhibition, Molecular Docking, and Gene Expression Related to Alzheimer’s Disease
Evaluation of Selected Plant Phenolics via Beta-Secretase-1 Inhibition, Molecular Docking, and Gene Expression Related to Alzheimer’s Disease Open
Background: The goal of the current study was to investigate the inhibitory activity of six phenolic compounds, i.e., rosmarinic acid, gallic acid, oleuropein, epigallocatechin gallate (EGCG), 3-hydroxytyrosol, and quercetin, against β-sit…
View article: Enzyme Inhibitory Activities and RP‐HPLC Analysis of <i>Geranium</i> and <i>Erodium</i> Species
Enzyme Inhibitory Activities and RP‐HPLC Analysis of <i>Geranium</i> and <i>Erodium</i> Species Open
The genera Geranium and Erodium (Geraniaceae) have been documented to possess diverse ethnopharmacological uses, including diabetes mellitus. Relevant to their ethnopharmacological use, the current study aimed to evaluate the α‐glucosidase…
View article: Natural treatment approaches for varicose veins: A brief review of the literature
Natural treatment approaches for varicose veins: A brief review of the literature Open
Chronic venous insufficiency (CVI) is a widespread condition affecting millions worldwide. Each year, approximately 150,000 new patients are diagnosed with CVI, and nearly $500 million is used in the care of these patients. The venous syst…
View article: Imperative Role of Natural Product Chemistry in Cosmeceutical R&D - Phytonanocosmeceuticals
Imperative Role of Natural Product Chemistry in Cosmeceutical R&D - Phytonanocosmeceuticals Open
Natural product chemistry has always been attractive for drug and cosmetic industries as natural products can address these industries very well. By consumer demand, the cosmetic industry is looking for innovative, safer, more effective, a…
View article: Potential of Mushrooms Bioactive for the Treatment of Skin Diseases and Disorders
Potential of Mushrooms Bioactive for the Treatment of Skin Diseases and Disorders Open
Mushrooms have long been revered not only as a staple food source but also for their potential medicinal properties. Their role as a natural repository of bioactive compounds positions them uniquely in the pharmaceutical domain, with parti…
View article: CCDC 2161839: Experimental Crystal Structure Determination
CCDC 2161839: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: X-ray crystalographic data, absolute configuration, and anticholinesterase effect of dihydromyricitrin 3-O-rhamnoside
X-ray crystalographic data, absolute configuration, and anticholinesterase effect of dihydromyricitrin 3-O-rhamnoside Open
Based on our continuous effort to investigate chemistry and biology of the plant secondary metabolites, we were able to isolate a glycosidal flavonoid 1 from the Wild Egyptian Artichoke. The activity of dihydromyricetin 3- O -rhamnoside (s…
View article: Novel 2,6-disubstituted-3-(2H)-pyridazones as Cholinesterase Inhibitors: In vitro Enzyme Inhibition and In silico Molecular Modelling and Dynamic Studies
Novel 2,6-disubstituted-3-(2H)-pyridazones as Cholinesterase Inhibitors: In vitro Enzyme Inhibition and In silico Molecular Modelling and Dynamic Studies Open
The approach proposed as the cholinergic hypothesis for Alzheimer's Disease contributed significantly to the explanation of cognitive decline observed in the elderly and Alzheimer's patients due to dysfunction of neurons containing acetylc…
View article: Kombucha – An ancient fermented beverage with desired bioactivities: A narrowed review
Kombucha – An ancient fermented beverage with desired bioactivities: A narrowed review Open
Kombucha, originated in China 2000 years ago, is a sour and sweet-tasted drink, prepared traditionally through fermentation of black tea. During the fermentation of kombucha, consisting of mainly acidic compounds, microorganisms, and a tin…
View article: Antiproliferative and Cytotoxic Activity of Geraniaceae Plant Extracts Against Five Tumor Cell Lines
Antiproliferative and Cytotoxic Activity of Geraniaceae Plant Extracts Against Five Tumor Cell Lines Open
This is the first study to report the potential antiproliferative effects of ethanol extracts of several Geraniaceae species.
View article: Outlining In Vitro and In Silico Cholinesterase Inhibitory Activity of Twenty-Four Natural Products of Various Chemical Classes: Smilagenin, Kokusaginine, and Methyl Rosmarinate as Emboldening Inhibitors
Outlining In Vitro and In Silico Cholinesterase Inhibitory Activity of Twenty-Four Natural Products of Various Chemical Classes: Smilagenin, Kokusaginine, and Methyl Rosmarinate as Emboldening Inhibitors Open
Cholinesterase (ChE) inhibition is an important treatment strategy for Alzheimer’s disease (AD) as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are involved in the pathology of AD. In the current work, ChE inhibitory potent…
View article: Massachusetts General Hospital Hairpulling Scale: Validity and Reliability Study of the Turkish Form
Massachusetts General Hospital Hairpulling Scale: Validity and Reliability Study of the Turkish Form Open
This study showed that the MGH-HPS-TR can be used as a valid and reliable psychometric tool in Turkey.
View article: Cholinesterase and Tyrosinase Inhibitory Potential and Antioxidant Capacity of <İ>Lysimachia verticillaris</İ> L. and Isolation of the Major Compounds
Cholinesterase and Tyrosinase Inhibitory Potential and Antioxidant Capacity of <İ>Lysimachia verticillaris</İ> L. and Isolation of the Major Compounds Open
LV may be a potential herbal source for treatment of neurodegenerative diseases based on its strong antioxidant activity and significant cholinesterase inhibition similar to that of the reference.
View article: Norditerpenoids with Selective Anti-Cholinesterase Activity from the Roots of Perovskia atriplicifolia Benth.
Norditerpenoids with Selective Anti-Cholinesterase Activity from the Roots of Perovskia atriplicifolia Benth. Open
Inhibition of cholinesterases remains one of a few available treatment strategies for neurodegenerative dementias such as Alzheimer’s disease and related conditions. The current study was inspired by previous data on anticholinesterase pro…
View article: Evaluation of collagenase, elastase and tyrosinase inhibitory activities of Cotinus coggygria Scop. through in vitro and in silico approaches
Evaluation of collagenase, elastase and tyrosinase inhibitory activities of Cotinus coggygria Scop. through in vitro and in silico approaches Open
Cotinus coggygria Scop. (Anacardiaceae, syn: Rhus cotinus L.) is known as "boyacı sumağı, sarı boya, duman ağacı" in Turkish and "smoke tree" in English. It is commonly grown in Southern Europe and Anatolia. The leaves have been used due t…
View article: Molecular approach to promising cholinesterase inhibitory effect of several amaryllidaceae alkaloids: Further re-investigation
Molecular approach to promising cholinesterase inhibitory effect of several amaryllidaceae alkaloids: Further re-investigation Open
All cholinesterase (ChE) inhibitory drugs in clinical use are nitrogenous compounds and among them, galanthamine as the latest anticholinesterase drug, contains a tetrahydroisoquinoline structure. For this reason, isoquinoline alkaloids se…
View article: Golden Pigment Curcumin: An Inspiring Antiviral Molecular Model for COVID-19 Drug Design
Golden Pigment Curcumin: An Inspiring Antiviral Molecular Model for COVID-19 Drug Design Open
COVID-19 caused by a new type of coronavirus (SARS-CoV-2) originated in China has speedily become a frightening pandemic all over the world. Despite of intense efforts relevant to experimental and clinical studies since the start of the CO…
View article: Yuccalechins A–C from the Yucca schidigera Roezl ex Ortgies Bark: Elucidation of the Relative and Absolute Configurations of Three New Spirobiflavonoids and Their Cholinesterase Inhibitory Activities
Yuccalechins A–C from the Yucca schidigera Roezl ex Ortgies Bark: Elucidation of the Relative and Absolute Configurations of Three New Spirobiflavonoids and Their Cholinesterase Inhibitory Activities Open
The ethyl acetate fraction of the methanolic extract of Yucca schidigera Roezl ex Ortgies bark exhibited moderate acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity (IC50 47.44 and 47.40 µg mL−1, respectively)…
View article: Studies on Natural Cosmetic R & D – From Laboratory to Prototype Product
Studies on Natural Cosmetic R & D – From Laboratory to Prototype Product Open
Cosmetic sector has been developing day by day and more products based on scientific search are released to the market. In this sector, particularly natural cosmetics are in a great demand, which also raises the need for more effective and…