Faustine Henot
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View article: Toward Site-Specific Characterization of Structural Perturbations on Glycosylated Fc Using NMR at Natural Abundance
Toward Site-Specific Characterization of Structural Perturbations on Glycosylated Fc Using NMR at Natural Abundance Open
Monoclonal antibodies (mAbs) are leading therapeutic agents due to their high specificity and limited side effects. Ensuring their structural integrity under stress and maintaining batch consistency require robust quality control. Methyl 2…
View article: A fast and efficient strategy for the NMR assignment of Fab methyl groups
A fast and efficient strategy for the NMR assignment of Fab methyl groups Open
Owing to their high specificity and therapeutic effectiveness, monoclonal antibodies (mAbs) have rapidly become one of the leading classes of biologic drugs used to treat critical illnesses. The antigen-binding fragment (Fab) of mAbs plays…
View article: Visualizing the transiently populated closed-state of human HSP90 ATP binding domain
Visualizing the transiently populated closed-state of human HSP90 ATP binding domain Open
HSP90 are abundant molecular chaperones, assisting the folding of several hundred client proteins, including substrates involved in tumor growth or neurodegenerative diseases. A complex set of large ATP-driven structural changes occurs dur…
View article: HSP90 une cible thérapeutique dynamique : modulation des conformations peuplées par la liaison de ligands
HSP90 une cible thérapeutique dynamique : modulation des conformations peuplées par la liaison de ligands Open
HSP90 is a major chaperone engaged in the folding, stabilization and aggregation prevention of a plethora of client proteins. Among HSP90 clients are found numerous oncoproteins implicated in the hallmarks of cancer. Additionally, it has a…
View article: Visualizing the Transiently Populated Closed-State of Human HSP90 ATP Binding Domain
Visualizing the Transiently Populated Closed-State of Human HSP90 ATP Binding Domain Open
HSP90 are abundant molecular chaperones, assisting the folding of several hundred client proteins, including substrates involved in tumor growth or neurodegenerative diseases. A complex set of large ATP-driven structural changes occurs dur…