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View article: The DREAM Programme, lessons learnt from 20 years of experience
The DREAM Programme, lessons learnt from 20 years of experience Open
We describe characteristics and results from the DREAM Program, a public health program initiated in Mozambique in 2002 to fight AIDS and other chronic diseases in Sub Saharan Africa. The DREAM Program is currently implemented in 10 countr…
View article: The global response to HIV/AIDS in sub-Saharan Africa: achievements, challenges, and perspectives for the future
The global response to HIV/AIDS in sub-Saharan Africa: achievements, challenges, and perspectives for the future Open
Over four decades, the global response to HIV/AIDS has transformed the disease into a manageable chronic condition, driven by advances in antiretroviral therapy, global financing, and ambitious targets like the 90-90-90 and 95-95-95 goals.…
View article: Hypertension outcomes in a fragile setting: predictors of blood pressure reduction and control in the Central African Republic
Hypertension outcomes in a fragile setting: predictors of blood pressure reduction and control in the Central African Republic Open
Background Hypertension is a leading contributor to cardiovascular disease and early mortality, and its impact is growing rapidly in low-income countries. In the Central African Republic, the condition represents a major and under-addresse…
View article: HIV Dolutegravir resistance and multiclass failure in Mozambique: findings from a real-world cohort
HIV Dolutegravir resistance and multiclass failure in Mozambique: findings from a real-world cohort Open
View article: The warning bell of Dolutegravir resistance: rethinking HIV service models in Africa
The warning bell of Dolutegravir resistance: rethinking HIV service models in Africa Open
The emergence of resistance to Dolutegravir (DTG)—the cornerstone of first-line antiretroviral therapy—marks a critical turning point in the fight against HIV in Africa. Once considered unlikely due to DTG’s high genetic barrier, resistanc…
View article: A comparative analysis of Africa's regional demographic and epidemiological transitions: Policy implications for public health
A comparative analysis of Africa's regional demographic and epidemiological transitions: Policy implications for public health Open
These findings suggest the need for region-specific public health strategies across Africa. Northern and Southern Africa should prioritize NCD prevention and management, with early detection, care, and lifestyle interventions. Western and …
View article: Assessing changes in frailty status in an elderly population: Analysis of results from the SFGE tool
Assessing changes in frailty status in an elderly population: Analysis of results from the SFGE tool Open
This pilot study explores the relationship between frailty and public health in older adults, evaluating the impact of an Individualized Care Plan (ICP) on frailty status over time. The study involved 125 individuals aged 65 and over recru…
View article: Between war and pestilence: the impact of armed conflicts on vaccination efforts: a review of literature
Between war and pestilence: the impact of armed conflicts on vaccination efforts: a review of literature Open
Armed conflicts profoundly undermine vaccination efforts, disrupting healthcare systems, displacing populations, and enabling the resurgence of vaccine-preventable diseases (VPDs). This narrative review explores the relationship between co…
View article: Italian Oncology at the Crossroads: Between Hospital Bed Cuts and the Need for a Transition to Integrated Community-Based Simultaneous Care
Italian Oncology at the Crossroads: Between Hospital Bed Cuts and the Need for a Transition to Integrated Community-Based Simultaneous Care Open
Background: In Italy, public health investments have not kept pace with the rising demand for cancer care. Hospitalization costs are increasing, and length of stay (LOS) remains a critical metric for hospital efficiency and care quality. M…
View article: HIV Dolutegravir Resistance and Multiclass Failure in Mozambique: Findings from a Real-World Cohort
HIV Dolutegravir Resistance and Multiclass Failure in Mozambique: Findings from a Real-World Cohort Open
Background Dolutegravir (DTG) is the anchor drug of the first-line agent for HIV treatment globally, including low- and middle-income countries. Although clinical trials report low rates of integrase inhibitor resistance, real-world data f…
View article: The role of high-sensitivity C-reaction protein in the prediction of long-term mortality in people living with HIV: Results from the IDEA-TB cohort study in Kenya
The role of high-sensitivity C-reaction protein in the prediction of long-term mortality in people living with HIV: Results from the IDEA-TB cohort study in Kenya Open
View article: Brief communication: virological outcomes and dolutegravir resistance mutations in HIV-infected patients: a multicenter retrospective cohort study in Mozambique
Brief communication: virological outcomes and dolutegravir resistance mutations in HIV-infected patients: a multicenter retrospective cohort study in Mozambique Open
View article: Virological Outcomes and Dolutegravir Resistance Mutations in HIV-infected Patients: A Multicenter Retrospective Cohort Study in Mozambique
Virological Outcomes and Dolutegravir Resistance Mutations in HIV-infected Patients: A Multicenter Retrospective Cohort Study in Mozambique Open
Introduction The global HIV epidemic remains a public health challenge. Dolutegravir (DTG) has become a cornerstone of antiretroviral therapy (ART) regimens due to its efficacy and tolerability. However, the emergence of DTG resistance is …
View article: Determinants of gender-equitable attitudes among adult men in a health education program: a cross-sectional study in Southern Malawi
Determinants of gender-equitable attitudes among adult men in a health education program: a cross-sectional study in Southern Malawi Open
View article: Exploring diseases burden in HIV population: Results from the CHAO (Comorbidities in HIV/AIDS outpatients) cross-sectional study in Kenya
Exploring diseases burden in HIV population: Results from the CHAO (Comorbidities in HIV/AIDS outpatients) cross-sectional study in Kenya Open
View article: Perception of Utility and Efficacy of Implementation of <scp>TEC</scp>‐<scp>MED</scp> Model of Care for Frail Older People and Their Caregivers: A Qualitative Study
Perception of Utility and Efficacy of Implementation of <span>TEC</span>‐<span>MED</span> Model of Care for Frail Older People and Their Caregivers: A Qualitative Study Open
Introduction The global population is ageing, and healthcare systems continue to adopt outdated social models of ageing that do not respond to older people's needs. The aim of this study was to explore the experiences of participants in th…
View article: The financial burden of healthcare-associated infections: a propensity score analysis in an Italian healthcare setting
The financial burden of healthcare-associated infections: a propensity score analysis in an Italian healthcare setting Open
View article: Seroprotection against tetanus in HIV-exposed and HIV-unexposed infants in Malawi in 2019–2020
Seroprotection against tetanus in HIV-exposed and HIV-unexposed infants in Malawi in 2019–2020 Open
In Malawi, tetanus toxoid vaccination (TTV) is recommended in pregnancy, but few studies have assessed the prevalence of infant seroprotection against tetanus. Anti-TT levels from 84 6-week-old infants, born in 2019–2020 to mothers living …
View article: Device associated healthcare associated infection (DA-HAI): a detailed analysis of risk factors and outcomes in a university hospital in Rome, Italy
Device associated healthcare associated infection (DA-HAI): a detailed analysis of risk factors and outcomes in a university hospital in Rome, Italy Open
This study suggests that specific invasive procedures, such as temporary tracheostomy, significantly increase HAI risks. The results highlighting the need for targeted infection prevention and control procedures and supports the need for i…
View article: The impact of COVID-19 pandemic in tuberculosis diagnosis in sub-Saharan Africa: data from DREAM program in Mozambique
The impact of COVID-19 pandemic in tuberculosis diagnosis in sub-Saharan Africa: data from DREAM program in Mozambique Open
Background: TB is a global emergency, COVID-19 reversed the trend in TB mortality reduction to 2017 levels. Mozambique is one of the highest-burden countries with 368 new cases per 100.000 population in 2020.Objectives: This analysis aims …
View article: Implementing HbA1c monitoring in sub-Saharan Africa: Lessons learnt from a pilot project in Mozambique
Implementing HbA1c monitoring in sub-Saharan Africa: Lessons learnt from a pilot project in Mozambique Open
View article: Not only COVID-19: a systematic review of anti-COVID-19 measures and their effect on healthcare-associated infections
Not only COVID-19: a systematic review of anti-COVID-19 measures and their effect on healthcare-associated infections Open
Anti-COVID-19 measures have shown selective efficacy in preventing HAIs. The study emphasizes the need for context-specific strategies and increased focus on regions with limited resources. Continued research is essential to refine infecti…
View article: PA-749 Gender power dynamics in healthcare decision-making: a cross-section study in Southern Malawi
PA-749 Gender power dynamics in healthcare decision-making: a cross-section study in Southern Malawi Open
Background Gender is a social determinant of health. Gender power dynamics can impact women's and children's health outcomes. The Demographic and Health Survey (2015) showed that 68% of women participated in decisions about their own healt…
View article: COVID-19 infection rate and mortality in a local health authority in Italy: Differences between home-dwelling and residential older adults
COVID-19 infection rate and mortality in a local health authority in Italy: Differences between home-dwelling and residential older adults Open
These findings confirm the high mortality in Long-Term Care Facilities and provide new information on the infection rate. The containment measures adopted in the Long-Term Care Facilities during the COVID-19 pandemic, show limited correlat…
View article: Costs and control strategies of healthcare-associated infections in an Italian university hospital
Costs and control strategies of healthcare-associated infections in an Italian university hospital Open
Backgrounds Healthcare-associated infections (HAIs) increase morbidity, mortality, and costs, necessitating effective prevention strategies. This study estimates the additional costs of HAIs in a university hospital in Rome, Italy Policlin…
View article: Men's Views on Gender Equality: Attitudes and Behaviors at Male-Friendly Clinics in Malawi
Men's Views on Gender Equality: Attitudes and Behaviors at Male-Friendly Clinics in Malawi Open
Background Malawi ranks 173 out of 188 on the UN's Gender Inequality Index (GII) and Malawi has the eighth highest child marriage rate in the world. While previous research has mostly focused on understanding gender roles and norms from wo…
View article: Insufficient measles antibody protection in 6‐month‐old Malawian infants: Reconsider vaccination schedule?
Insufficient measles antibody protection in 6‐month‐old Malawian infants: Reconsider vaccination schedule? Open
Measles vaccination is currently recommended at 9 months, since maternal antibodies are supposed to protect infants until that age. In this study of 6‐month‐old Malawian infants 98.3% (58/59) had non‐protective IgG levels against measles, …
View article: Micronutrient and Nutritional Status of HIV-Exposed and HIV-Unexposed Malawian Infants in the First Year of Life: Assessment of Ferritin, Vitamin A, and D Status and Its Association with Growth
Micronutrient and Nutritional Status of HIV-Exposed and HIV-Unexposed Malawian Infants in the First Year of Life: Assessment of Ferritin, Vitamin A, and D Status and Its Association with Growth Open
Breastfed Malawian infants from Human Immunodeficiency Virus (HIV)-uninfected and HIV-infected women who received antiretroviral therapy were followed until 12 months of age, allowing us to evaluate plasma levels of ferritin, vitamin A (as…
View article: Rates of Seroprotection against Vaccine-Preventable Infectious Diseases in HIV-Exposed and -Unexposed Malawian Infants
Rates of Seroprotection against Vaccine-Preventable Infectious Diseases in HIV-Exposed and -Unexposed Malawian Infants Open
Background: The evaluation of seroprotection rates against vaccine-preventable infectious diseases allows for the identification of risk populations. HIV-exposed infants, even if not infected with HIV, have higher morbidity and mortality i…
View article: On-Field Test of Tuberculosis Diagnosis through Exhaled Breath Analysis with a Gas Sensor Array
On-Field Test of Tuberculosis Diagnosis through Exhaled Breath Analysis with a Gas Sensor Array Open
Tuberculosis (TB) is among the more frequent causes of death in many countries. For pulmonary TB, early diagnosis greatly increases the efficiency of therapies. Although highly sensitive tests based on nucleic acid amplification tests (NAA…