Futian Tang
YOU?
Author Swipe
View article: Limited Proteolysis-Coupled Mass Spectrometry (LiP-MS): A Cutting-Edge Tool for De Novo Drug Target Discovery
Limited Proteolysis-Coupled Mass Spectrometry (LiP-MS): A Cutting-Edge Tool for De Novo Drug Target Discovery Open
The identification of drug targets is fundamental to drug development. Traditional affinity-based target screening methods, including chemical biology probes and biotin labeling techniques, rely on the presumption of pre-existing knowledge…
Multimodal artificial intelligence technology in the precision diagnosis and treatment of gastroenterology and hepatology: Innovative applications and challenges Open
With the rapid development of artificial intelligence (AI) technology, multimodal data integration has become an important means to improve the accuracy of diagnosis and treatment in gastroenterology and hepatology. This article systematic…
Cholecystitis and cholangiocarcinoma: a two-sample Mendelian randomization study Open
We found evidence supporting a causal effect between cholecystitis and cholangiocarcinoma, indicating an increased likelihood of cholangiocarcinoma in patients with cholecystitis through MR analysis.These findings may help inform clinical …
View article: <scp>BCL</scp>‐2 Inhibitor Regulates Number, Function, and Antitumor Immunity of T Cells by Influencing Glycolysis in <scp>AML</scp>
<span>BCL</span>‐2 Inhibitor Regulates Number, Function, and Antitumor Immunity of T Cells by Influencing Glycolysis in <span>AML</span> Open
BCL‐2 is one of the key genes in the mitochondrial apoptotic pathway, and BCL‐2 inhibitor Venetoclax (VEN) is the preferred targeted drug for acute myeloid leukemia (AML) patients. However, the effects of VEN on immune cells and antitumor …
View article: Study on the mechanism of gracillin inhibiting the<i> proliferation</i> of lung cancer NCI-H1299 cells based on MAPK signaling pathway
Study on the mechanism of gracillin inhibiting the<i> proliferation</i> of lung cancer NCI-H1299 cells based on MAPK signaling pathway Open
In this study, we investigated the potential of gracillin, a steroidal saponin compound, as an anticancer agent against non-small cell lung cancer (NSCLC) and explored its impact on autophagy mechanisms. Gracillin significantly inhibited N…
Endoscopic treatment of benign esophageal strictures: Advances and challenges Open
Benign esophageal stricture is characterized by the narrowing of the digestive tract lumen due to multiple factors. Endoscopic treatment is the first treatment choice and includes endoscopic dilatation, drug injection, stenosis incision, s…
The role of TMEM119 in gastric adenocarcinoma and its specific effects on immunity Open
Objective To investigate the prognostic significance and immunological implication of transmembrane protein 119 (TMEM119) in stomach adenocarcinoma (STAD). Methods This study included STAD-associated data obtained from The Cancer Genome At…
ITGA4 as a potential prognostic and immunotherapeutic biomarker in human cancer and its clinical significance in gastric cancer: an integrated analysis and validation Open
Background Integrin Subunit Alpha 4 (ITGA4), a member of the integrin protein family, is involved in the progression of malignant tumors. However, its role across different cancer types is not well understood. Methods Utilizing multi-omics…
The dual role of gut microbiota in pancreatic cancer: new insights into onset and treatment Open
Pancreatic cancer ranks among the most lethal digestive malignancies, exhibiting a steadily increasing incidence and mortality worldwide. Despite significant advances in cancer research, the 5-year survival rate remains below 10%, predomin…
Establishment and validation of a novel CD8+ T cell-associated prognostic signature for predicting clinical outcomes and immunotherapy response in hepatocellular carcinoma via integrating single-cell RNA-seq and bulk RNA-seq Open
CD8+ T lymphocytes are critical in the immune response against neoplasms, yet the prognostic relevance of CD8+ T cell-associated genes in hepatocellular carcinoma (HCC) is not fully understood. We sourced single-cell RNA-sequencing (scRNA-…
Cholecystitis and cholangiocarcinoma: a two-sample mendelian randomization study Open
Background In recent years, the incidence of cholangiocarcinoma increases. Epidemiological studies suggest that cholecystitis elevates the risk of hepatobiliary cancer. However, an independent causal relationship remains unrevealed. Observ…
UBE2L3 expression in human gastric cancer and its clinical significance Open
Purpose Gastric cancer (GC) is prevalent as one of the most common malignant tumors globally, with a particularly high incidence in China. The role of UBE2L3 in the initiation and progression of various cancers has been well documented, bu…
Use of Transcriptome Sequencing to Analyze the Effects of Different Doses of an Astragalus-Rhubarb-Saffron Mixture in Mice with Diabetic Kidney Disease Open
A high-dose of the Astragalus-rhubarb-saffron TCM provided the best prevention of DKD. Analysis of the kidney transcriptome suggested that this TCM mixture may prevent DKD by altering immune responses and oxygen delivery by hemoglobin.
Synchronous occurrence of gastric cancer and gastrointestinal stromal tumor: A case report and review of the literature Open
Minimally invasive surgery is increasingly indicated in the management of malignant disease. Although oesophagectomy is a difficult operation, with a long learning curve, there is actually a shift towards the laparoscopic/thoracoscopic/ ro…
Angiotensin Receptor Neprilysin Inhibition mediates Renal Protection by ARNI (Sacubatril Valsartan) in Rats with Spontaneous Hypertension Open
Background This article aims to present research pertaining to the effect of angiotensin receptor-neprilysin double blocker on blocking the inflammatory mechanism mediated by NLRP3 inflammasome on hypertensive nephropathy. ARNI has not onl…
Calpain-1 Mediated Mitochondria ROS/NLRP3 Inflammasome in Atherosclerosis Open
Calpains are calcium-activated cysteine proteases. There are two main isoforms of calpain that are ubiquitously expressed in tissues, calpain μ or calpain 1, which requires micromolar Ca2+ for activation, and calpain or 2, which requires m…
View article: The yin-yang of immunity: Immune dysregulation in myelodysplastic syndrome with different risk stratification
The yin-yang of immunity: Immune dysregulation in myelodysplastic syndrome with different risk stratification Open
Myelodysplastic syndrome (MDS) is a heterogeneous group of myeloid clonal diseases with diverse clinical courses, and immune dysregulation plays an important role in the pathogenesis of MDS. However, immune dysregulation is complex and het…
ZNF165 as a potential novel immunotherapeutic target for gastric cancer Open
Background: Cancer testis antigens (CTAs) are an extensive gene family with a unique expression pattern restricted to testis tissues, but aberrantly high expressed in a variety of cancer tissues. In view of this, CTAs are typically conside…
Inhibition of miRNA-1-Mediated Inflammation and Autophagy by Astragaloside IV Improves Lipopolysaccharide-Induced Cardiac Dysfunction in Rats Open
These results suggest that AS-IV attenuated cardiac dysfunction caused by LPS by inhibiting miR-1-mediated inflammation and autophagy, thereby providing a novel mechanism for the protection against cardiac diseases.
Special Chimeric Antigen Receptor (CAR) Modifications of T Cells: A Review Open
Chimeric antigen receptor (CAR) -T cell therapy has become one of the hot topics in tumor immunity research in recent years. Although CAR-T cell therapy is highly effective in treating hematological malignancies, there are numerous obstacl…
A Bibliometric and Knowledge-Map Analysis of CAR-T Cells From 2009 to 2021 Open
Objectives A bibliometric and knowledge-map analysis is used to explore hotspots’ evolution and development trends in the CAR-T cell field. By looking for research hotspots and new topics, we can provide new clues and ideas for researchers…
Echinocystic acid induces the apoptosis, and inhibits the migration and invasion of non-small cell lung cancer cells Open
An increasing amount of evidence has demonstrated the anticancer activity of triterpenes extracted from traditional medicines. Echinocystic acid (EA), a natural triterpene isolated from Eclipta prostrata (L.) L., has previously been shown …