Fay Newton
YOU?
Author Swipe
View article: Autophagy disruption and mitochondrial stress precede photoreceptor necroptosis in multiple mouse models of inherited retinal disorders
Autophagy disruption and mitochondrial stress precede photoreceptor necroptosis in multiple mouse models of inherited retinal disorders Open
Inherited retinal diseases (IRDs) are a leading cause of blindness worldwide. One of the greatest barriers to developing treatments for IRDs is the heterogeneity of these disorders, with causative mutations identified in over 280 genes. It…
View article: Autophagy disruption and mitochondrial stress precede photoreceptor necroptosis in multiple mouse models of inherited retinal disorders
Autophagy disruption and mitochondrial stress precede photoreceptor necroptosis in multiple mouse models of inherited retinal disorders Open
Inherited retinal diseases (IRDs) are a leading cause of blindness worldwide. One of the greatest barriers to developing treatments for IRDs is the heterogeneity of these disorders, with causative mutations identified in over 280 genes. It…
View article: Ciliary tip actin dynamics regulate photoreceptor outer segment integrity
Ciliary tip actin dynamics regulate photoreceptor outer segment integrity Open
As signalling organelles, cilia regulate their G protein-coupled receptor content by ectocytosis, a process requiring localised actin dynamics to alter membrane shape. Photoreceptor outer segments comprise an expanse of folded membranes (d…
View article: Ciliary tip actin dynamics regulate the cadence of photoreceptor disc formation
Ciliary tip actin dynamics regulate the cadence of photoreceptor disc formation Open
As signalling organelles, primary cilia regulate their membrane G protein-coupled receptor (GPCR) content by ectocytosis, a process requiring localised actin dynamics at their tip to alter membrane shape.(1, 2) Mammalian photoreceptor oute…
View article: The dynamics of protein localisation to restricted zones within <i>Drosophila</i> mechanosensory cilia
The dynamics of protein localisation to restricted zones within <i>Drosophila</i> mechanosensory cilia Open
The Drosophila chordotonal neuron cilium is the site of mechanosensory transduction. The cilium has a 9+0 axoneme structure and is highly sub-compartmentalised, with proximal and distal zones harbouring different TRP channels and the proxi…
View article: Mechanisms of Photoreceptor Death in Retinitis Pigmentosa
Mechanisms of Photoreceptor Death in Retinitis Pigmentosa Open
Retinitis pigmentosa (RP) is the most common cause of inherited blindness and is characterised by the progressive loss of retinal photoreceptors. However, RP is a highly heterogeneous disease and, while much progress has been made in devel…
View article: Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies
Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies Open
The motile cilium/flagellum is an ancient eukaryotic organelle. The molecular machinery of ciliary motility comprises a variety of cilium-specific dynein motor complexes along with other complexes that regulate their activity. Assembling t…
View article: Coordinate post-transcriptional repression of Dpp-dependent transcription factors attenuates signal range during development
Coordinate post-transcriptional repression of Dpp-dependent transcription factors attenuates signal range during development Open
Precise control of the range of signalling molecule action is critical for correct cell fate patterning during development. For example, Drosophila ovarian germline stem cells (GSCs) are maintained by exquisitely short-range BMP signalling…