Fay Y. Womer
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View article: Identifying transdiagnostic neurobiomarkers for precision major psychiatric disorders <i>via</i> machine learning: Causes, findings, and future directions
Identifying transdiagnostic neurobiomarkers for precision major psychiatric disorders <i>via</i> machine learning: Causes, findings, and future directions Open
The diagnostic criteria of psychiatric disorders rest solely on symptoms rather than etiologies; this led to the lack of objective biomarkers for diagnosis, differential diagnosis and treatment of major psychiatric disorders (MPDs) includi…
View article: Evaluation of the efficacy of group cognitive behavioral therapy on anxiety in college students based on wearable devices and mobile applications: a randomized controlled trial
Evaluation of the efficacy of group cognitive behavioral therapy on anxiety in college students based on wearable devices and mobile applications: a randomized controlled trial Open
ClinicalTrials.gov (NCT05913349), trial registration date: June 13, 2023 (retrospectively registered).
View article: Characterizing the distinct imaging phenotypes, clinical behavior, and genetic vulnerability of brain maturational subtypes in mood disorders
Characterizing the distinct imaging phenotypes, clinical behavior, and genetic vulnerability of brain maturational subtypes in mood disorders Open
Background Mood disorders are characterized by great heterogeneity in clinical manifestation. Uncovering such heterogeneity using neuroimaging-based individual biomarkers, clinical behaviors, and genetic risks, might contribute to elucidat…
View article: Unmasking the mental health scars of COVID-19: A longitudinal investigation of children and adolescents in post-lockdown China
Unmasking the mental health scars of COVID-19: A longitudinal investigation of children and adolescents in post-lockdown China Open
The long-term mental health consequences of COVID-19 in children and adolescents remain unclear. We investigated the impact of COVID-19 infection on mental health after China's zero-COVID policy relaxation, focusing on symptom-specific and…
View article: Digital Dietary Behaviors in Individuals With Depression: Real-World Behavioral Observation
Digital Dietary Behaviors in Individuals With Depression: Real-World Behavioral Observation Open
Background Depression is often accompanied by changes in behavior, including dietary behaviors. The relationship between dietary behaviors and depression has been widely studied, yet previous research has relied on self-reported data which…
View article: Integrative omics analysis reveals epigenomic and transcriptomic signatures underlying brain structural deficits in major depressive disorder
Integrative omics analysis reveals epigenomic and transcriptomic signatures underlying brain structural deficits in major depressive disorder Open
Several lines of evidence support the involvement of transcriptomic and epigenetic mechanisms in the brain structural deficits of major depressive disorder (MDD) separately. However, research in these two areas has remained isolated. In th…
View article: Towards a neuroimaging biomarker for predicting cognitive behavioural therapy outcomes in treatment-naive depression: Preliminary findings
Towards a neuroimaging biomarker for predicting cognitive behavioural therapy outcomes in treatment-naive depression: Preliminary findings Open
Clear prognostic indicators of cognitive behavioural therapy (CBT) are lacking for depression. This study aims to identify a biomarker that predicts CBT outcomes in depression. We developed a machine learning algorithm to predict post-CBT …
View article: School-based Evaluation Advancing Response for Child Health (SEARCH): a mixed longitudinal cohort study from multifaceted perspectives in Jiangsu, China
School-based Evaluation Advancing Response for Child Health (SEARCH): a mixed longitudinal cohort study from multifaceted perspectives in Jiangsu, China Open
Background Schools play a crucial role in providing mental health services to children and adolescents. However, the vastness of the student population and mental health workforce shortage in China severely limit the capacity for adequate …
View article: Visual cortex repetitive transcranial magnetic stimulation (<scp>rTMS</scp>) reversing neurodevelopmental impairments in adolescents with major psychiatric disorders (<scp>MPDs</scp>): A cross‐species translational study
Visual cortex repetitive transcranial magnetic stimulation (<span>rTMS</span>) reversing neurodevelopmental impairments in adolescents with major psychiatric disorders (<span>MPDs</span>): A cross‐species translational study Open
Aims Neurodevelopmental impairments are closely linked to the basis of adolescent major psychiatric disorders (MPDs). The visual cortex can regulate neuroplasticity throughout the brain during critical periods of neurodevelopment, which ma…
View article: Digital Dietary Behaviors in Individuals With Depression: Real-World Behavioral Observation (Preprint)
Digital Dietary Behaviors in Individuals With Depression: Real-World Behavioral Observation (Preprint) Open
BACKGROUND Depression is often accompanied by changes in behavior, including dietary behaviors. The relationship between dietary behaviors and depression has been widely studied, yet previous research has relied on self-reported data whic…
View article: Neurodevelopmental trajectories, polygenic risk, and lipometabolism in vulnerability and resilience to schizophrenia
Neurodevelopmental trajectories, polygenic risk, and lipometabolism in vulnerability and resilience to schizophrenia Open
Background Schizophrenia (SZ) arises from a complex interplay involving genetic and molecular factors. Early intervention of SZ hinges upon understanding its vulnerability and resiliency factors in study of SZ and genetic high risk for SZ …
View article: Cross-species neuroimaging intermediate phenotypes deepen our understanding of depression
Cross-species neuroimaging intermediate phenotypes deepen our understanding of depression Open
Multiple genetic variants and their interplay with environmental factors have hindered the progress of mental disease research and the development of effective markers of neuropsychiatric disorders. Intermediate phenotypes like neuroimagin…
View article: Cross-species neuroimaging intermediate phenotypes deepen our understanding of depression
Cross-species neuroimaging intermediate phenotypes deepen our understanding of depression Open
Multiple genetic variants and their interplay with environmental factors have hindered the progress of mental disease research and the development of effective markers of neuropsychiatric disorders. Intermediate phenotypes like neuroimagin…
View article: A Neuroimaging-based Precision Medicine Framework for Depression
A Neuroimaging-based Precision Medicine Framework for Depression Open
Objective Developing a neuroimaging-based precision medicine framework for depression. Methods The study was conducted in two stages at two sites: development of a neuroimaging-based subtyping and precise repetitive transcranial magnetic s…
View article: A Real-World Observation of Antipsychotic Effects on Brain Volumes and Intrinsic Brain Activity in Schizophrenia
A Real-World Observation of Antipsychotic Effects on Brain Volumes and Intrinsic Brain Activity in Schizophrenia Open
Background The confounding effects of antipsychotics that led to the inconsistencies of neuroimaging findings have long been the barriers to understanding the pathophysiology of schizophrenia (SZ). Although it is widely accepted that antip…
View article: Neurobiological substrates of major psychiatry disorders: transdiagnostic associations between white matter abnormalities, neuregulin 1 and clinical manifestation
Neurobiological substrates of major psychiatry disorders: transdiagnostic associations between white matter abnormalities, neuregulin 1 and clinical manifestation Open
Background: Schizophrenia, bipolar disorder and major depressive disorder are increasingly being conceptualized as a transdiagnostic continuum. Disruption of white matter is a common alteration in these psychiatric disorders, but the molec…
View article: Antipsychotic Effects on Cortical Morphology in Schizophrenia and Bipolar Disorders
Antipsychotic Effects on Cortical Morphology in Schizophrenia and Bipolar Disorders Open
Background: Previous studies of atypical antipsychotic effects on cortical structures in schizophrenia (SZ) and bipolar disorder (BD) have findings that vary between the short and long term. In particular, there has not been a study explor…
View article: Transdiagnostic time‐varying dysconnectivity across major psychiatric disorders
Transdiagnostic time‐varying dysconnectivity across major psychiatric disorders Open
Dynamic functional connectivity (DFC) analysis can capture time‐varying properties of connectivity. However, studies on large samples using DFC to investigate transdiagnostic dysconnectivity across schizophrenia (SZ), bipolar disorder (BD)…
View article: Identifying and validating subtypes within major psychiatric disorders based on frontal–posterior functional imbalance via deep learning
Identifying and validating subtypes within major psychiatric disorders based on frontal–posterior functional imbalance via deep learning Open
Converging evidence increasingly implicates shared etiologic and pathophysiological characteristics among major psychiatric disorders (MPDs), such as schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD). Examining…
View article: Applying dimensional psychopathology: transdiagnostic associations among regional homogeneity, leptin and depressive symptoms
Applying dimensional psychopathology: transdiagnostic associations among regional homogeneity, leptin and depressive symptoms Open
Dimensional psychopathology and its neurobiological underpinnings could provide important insights into major psychiatric disorders, including major depressive disorder, bipolar disorder and schizophrenia. In a dimensional transdiagnostic …
View article: Structural and Functional Abnormities of Amygdala and Prefrontal Cortex in Major Depressive Disorder With Suicide Attempts
Structural and Functional Abnormities of Amygdala and Prefrontal Cortex in Major Depressive Disorder With Suicide Attempts Open
Finding neural features of suicide attempts (SA) in major depressive disorder (MDD) may be helpful in preventing suicidal behavior. The ventral and medial prefrontal cortex (PFC), as well as the amygdala form a circuit implicated in emotio…
View article: The Relationship Between Cognitive Dysfunction and Symptom Dimensions Across Schizophrenia, Bipolar Disorder, and Major Depressive Disorder
The Relationship Between Cognitive Dysfunction and Symptom Dimensions Across Schizophrenia, Bipolar Disorder, and Major Depressive Disorder Open
Background: Cognitive dysfunction is considered a core feature among schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD). Despite abundant literature comparing cognitive dysfunction among these disorders, the rel…
View article: Spontaneous low-frequency fluctuations in the neural system for emotional perception in major psychiatric disorders: amplitude similarities and differences across frequency bands
Spontaneous low-frequency fluctuations in the neural system for emotional perception in major psychiatric disorders: amplitude similarities and differences across frequency bands Open
Background: Growing evidence indicates both shared and distinct features of emotional perception in schizophrenia, bipolar disorder and major depressive disorder. In these disorders, alterations in spontaneous low-frequency fluctuations ha…
View article: Dynamic changes of functional segregation and integration in vulnerability and resilience to schizophrenia
Dynamic changes of functional segregation and integration in vulnerability and resilience to schizophrenia Open
Schizophrenia (SZ) is a highly heritable disease with neurodevelopmental origins and significant functional brain network dysfunction. Functional network is heavily influenced by neurodevelopment processes and can be characterized by the d…