Faye E. Mendelson
YOU?
Author Swipe
View article: Dietary Fatty Acid Composition Alters Gut Microbiome in Mice with Obesity-Induced Peripheral Neuropathy
Dietary Fatty Acid Composition Alters Gut Microbiome in Mice with Obesity-Induced Peripheral Neuropathy Open
Background: Peripheral neuropathy (PN), a complication of diabetes and obesity, progresses through a complex pathophysiology. Lifestyle interventions to manage systemic metabolism are recommended to prevent or slow PN, given the multifacto…
View article: Human neural stem cells restore spatial memory in a transgenic Alzheimer’s disease mouse model by an immunomodulating mechanism
Human neural stem cells restore spatial memory in a transgenic Alzheimer’s disease mouse model by an immunomodulating mechanism Open
Introduction Stem cells are a promising therapeutic in Alzheimer’s disease (AD) given the complex pathophysiologic pathways involved. However, the therapeutic mechanisms of stem cells remain unclear. Here, we used spatial transcriptomics t…
View article: Immunomodulating mechanisms of human neural stem cell transplantation in a transgenic Alzheimer’s disease mouse model
Immunomodulating mechanisms of human neural stem cell transplantation in a transgenic Alzheimer’s disease mouse model Open
Background Many pathways are implicated in pathogenesis of Alzheimer’s disease (AD). Stem cells are a promising strategy to simultaneously correct multiple pathways; however, therapeutic mechanisms of stem cells are not well described. Her…
View article: Long term high‐fat feeding induces cognitive impairment, alterations in microglial morphology, and spatial transcriptomic changes
Long term high‐fat feeding induces cognitive impairment, alterations in microglial morphology, and spatial transcriptomic changes Open
Background Obesity and metabolic dysfunction (Metabolic Syndrome, prediabetes, and diabetes) increase the risk of later life cognitive impairment, including dementias such as Alzheimer’s Disease 1‐3 . One common etiology that might underly…
View article: Human neural stem cells restore spatial memory in a transgenic Alzheimer’s disease mouse model by an immunomodulating mechanism
Human neural stem cells restore spatial memory in a transgenic Alzheimer’s disease mouse model by an immunomodulating mechanism Open
INTRODUCTION Stem cells are a promising therapeutic in Alzheimer’s disease (AD) given the complex pathophysiologic pathways involved. However, the therapeutic mechanisms of stem cells remain unclear. Here, we used spatial transcriptomics t…
View article: Palmitate and glucose increase amyloid precursor protein in extracellular vesicles: Missing link between metabolic syndrome and Alzheimer's disease
Palmitate and glucose increase amyloid precursor protein in extracellular vesicles: Missing link between metabolic syndrome and Alzheimer's disease Open
The metabolic syndrome (MetS) and Alzheimer's disease share several pathological features, including insulin resistance, abnormal protein processing, mitochondrial dysfunction and elevated inflammation and oxidative stress. The MetS consti…
View article: Dietary interventions improve diabetic kidney disease, but not peripheral neuropathy, in a <i>db/db</i> mouse model of type 2 diabetes
Dietary interventions improve diabetic kidney disease, but not peripheral neuropathy, in a <i>db/db</i> mouse model of type 2 diabetes Open
Patients with type 2 diabetes often develop the microvascular complications of diabetic kidney disease (DKD) and diabetic peripheral neuropathy (DPN), which decrease quality of life and increase mortality. Unfortunately, treatment options …
View article: Single‐cell <scp>RNA</scp>‐seq uncovers novel metabolic functions of Schwann cells beyond myelination
Single‐cell <span>RNA</span>‐seq uncovers novel metabolic functions of Schwann cells beyond myelination Open
Schwann cells (SCs) support peripheral nerves under homeostatic conditions, independent of myelination, and contribute to damage in prediabetic peripheral neuropathy (PN). Here, we used single‐cell RNA sequencing to characterize the transc…
View article: Modeling the innate inflammatory cGAS/STING pathway: sexually dimorphic effects on microglia and cognition in obesity and prediabetes
Modeling the innate inflammatory cGAS/STING pathway: sexually dimorphic effects on microglia and cognition in obesity and prediabetes Open
Introduction The prevalence of obesity, prediabetes, and diabetes continues to grow worldwide. These metabolic dysfunctions predispose individuals to neurodegenerative diseases and cognitive impairment, including dementias such as Alzheime…
View article: Single-cell RNA sequencing identifies hippocampal microglial dysregulation in diet-induced obesity
Single-cell RNA sequencing identifies hippocampal microglial dysregulation in diet-induced obesity Open
Obesity is a growing global concern in adults and youth with a parallel rise in associated complications, including cognitive impairment. Obesity induces brain inflammation and activates microglia, which contribute to cognitive impairment …
View article: Innate immune cGAS/STING in HFD‐induced obesity, prediabetes, and cognitive impairment
Innate immune cGAS/STING in HFD‐induced obesity, prediabetes, and cognitive impairment Open
Background Increasing in parallel with the worldwide aging population are rates of cognitive impairment and dementia, including Alzheimer’s Disease and Alzheimer’s Disease Related‐Dementia. Understanding underlying mechanisms that promote …
View article: cGAS/STING and innate brain inflammation following acute high-fat feeding
cGAS/STING and innate brain inflammation following acute high-fat feeding Open
Obesity, prediabetes, and diabetes are growing in prevalence worldwide. These metabolic disorders are associated with neurodegenerative diseases, particularly Alzheimer’s disease and Alzheimer’s disease related dementias. Innate inflammato…
View article: Natural killer cells associate with amyotrophic lateral sclersois in a sex- and age-dependent manner
Natural killer cells associate with amyotrophic lateral sclersois in a sex- and age-dependent manner Open
NK cells are innate immune cells implicated in ALS; whether NK cells impact ALS in a sex- and age-specific manner was investigated. Herein, NK cells were depleted in male and female SOD1G93A ALS mice, survival and neuroinflammation were as…
View article: Sex differences in insulin resistance, but not peripheral neuropathy, in a diet-induced prediabetes mouse model
Sex differences in insulin resistance, but not peripheral neuropathy, in a diet-induced prediabetes mouse model Open
Peripheral neuropathy (PN) is a common complication of prediabetes and diabetes and is an increasing problem worldwide. Existing PN treatments rely solely on glycemic control, which is effective in type 1 but not type 2 diabetes. Sex diffe…
View article: Differential effects of minocycline on microvascular complications in murine models of type 1 and type 2 diabetes
Differential effects of minocycline on microvascular complications in murine models of type 1 and type 2 diabetes Open
Diabetes is a global healthcare problem associated with enormous healthcare and personal costs. Despite glucose lowering agents that control glycaemia, both type 1 (T1D) and type (T2D) diabetes patients often develop microvascular complica…
View article: Differential Effects of Empagliflozin on Microvascular Complications in Murine Models of Type 1 and Type 2 Diabetes
Differential Effects of Empagliflozin on Microvascular Complications in Murine Models of Type 1 and Type 2 Diabetes Open
Microvascular complications account for the significant morbidity associated with diabetes. Despite tight glycemic control, disease risk remains especially in type 2 diabetes (T2D) patients and no therapy fully prevents nerve, retinal, or …
View article: Cytoplasmic TDP43 Binds microRNAs: New Disease Targets in Amyotrophic Lateral Sclerosis
Cytoplasmic TDP43 Binds microRNAs: New Disease Targets in Amyotrophic Lateral Sclerosis Open
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal, and incurable neurodegenerative disease. Recent studies suggest that dysregulation of gene expression by microRNAs (miRNAs) may play an important role in ALS pathogenesis. The re…
View article: Integrated lipidomic and transcriptomic analyses identify altered nerve triglycerides in mouse models of prediabetes and type 2 diabetes
Integrated lipidomic and transcriptomic analyses identify altered nerve triglycerides in mouse models of prediabetes and type 2 diabetes Open
Peripheral neuropathy (PN) is a complication of prediabetes and type 2 diabetes (T2D). Increasing evidence suggests that factors besides hyperglycaemia contribute to PN development, including dyslipidaemia. The objective of this study was …
View article: The Divergent Roles of Dietary Saturated and Monounsaturated Fatty Acids on Nerve Function in Murine Models of Obesity
The Divergent Roles of Dietary Saturated and Monounsaturated Fatty Acids on Nerve Function in Murine Models of Obesity Open
Neuropathy is the most common complication of prediabetes and diabetes and presents as distal-to-proximal loss of peripheral nerve function in the lower extremities. Neuropathy progression and disease severity in prediabetes and diabetes c…
View article: Juvenile murine models of prediabetes and type 2 diabetes develop neuropathy
Juvenile murine models of prediabetes and type 2 diabetes develop neuropathy Open
Peripheral neuropathy (neuropathy) is a common complication of obesity and type 2 diabetes in children and adolescents. To model this complication in mice, 5-week old male C57BL/6J mice were fed a high-fat diet to induce diet-induced obesi…