Bin Zheng
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View article: Effect of Fascia Iliaca Compartment Block with Liposomal Bupivacaine on the Quality of Recovery After Hip Fracture Surgery: A Prospective, Randomized, Controlled Clinical Study
Effect of Fascia Iliaca Compartment Block with Liposomal Bupivacaine on the Quality of Recovery After Hip Fracture Surgery: A Prospective, Randomized, Controlled Clinical Study Open
Fascia iliaca compartment block with liposomal bupivacaine can significantly improve the quality of postoperative recovery and reduce opioid consumption in patients undergoing hip fracture surgery.
View article: GSK3179106 ameliorates lipopolysaccharide-induced inflammation and acute lung injury by targeting P38 MAPK
GSK3179106 ameliorates lipopolysaccharide-induced inflammation and acute lung injury by targeting P38 MAPK Open
Acute lung injury (ALI) is a serious acute respiratory disease that can cause alveolar-capillary barrier disruption and pulmonary edema, respiratory failure and multiple organ dysfunction syndrome. However, there is no effective drugs in c…
View article: Multi-functional PEEK implants enhance osseointegration in OVX rat by remodeling the bone immune microenvironment
Multi-functional PEEK implants enhance osseointegration in OVX rat by remodeling the bone immune microenvironment Open
Osseointegration is significantly impeded in osteoporotic conditions due to the elevated levels of reactive oxygen species (ROS) and inflammation at the site of injury. To enhance bone regeneration in osteoporotic conditions, a modified po…
View article: Crocus sativus L. produces anti-inflammatory effects and regulates the NLRP3–NF-κB pathway
Crocus sativus L. produces anti-inflammatory effects and regulates the NLRP3–NF-κB pathway Open
Objective: This study aimed to evaluate the anti-inflammatory effects of petal and stamen extracts of saffron crocus ( Crocus sativus ) and explore the underlying mechanism. Methods: Local and systemic inflammation models were used to inve…
View article: Prediction of Remaining Fatigue Life of In-Service Bridge Cranes
Prediction of Remaining Fatigue Life of In-Service Bridge Cranes Open
At present, bridge crane accidents occur frequently, resulting in significant losses and casualties; to ensure the safe use of in-service bridge cranes, it is necessary to predict the residual fatigue life of in-service bridge cranes. Firs…
View article: The Particle Generation Method Utilizing an Arbitrary 2D Model for Smoothed Particle Hydrodynamics Modeling and Its Application in the Field of Snowdrift
The Particle Generation Method Utilizing an Arbitrary 2D Model for Smoothed Particle Hydrodynamics Modeling and Its Application in the Field of Snowdrift Open
This paper uses the SPH method to study snow disasters, including the snow flow model of a vertical water diffusion equation and heat balance equation. The advantage of the SPH method is that it can capture particles’ positions, which can …
View article: Numerical Simulation of Pollutant Spread in a Double-Deck Viaduct
Numerical Simulation of Pollutant Spread in a Double-Deck Viaduct Open
This study uses the computational fluid dynamics (CFD) method to investigate the effects of the depth-width ratio of a three-dimensional street valley and wind velocity on the flow field and pollutant spread in street valleys with double-d…
View article: Numerical Simulation and Parameter Optimization of a New Reed–Nylon Net Combined Sand Fence
Numerical Simulation and Parameter Optimization of a New Reed–Nylon Net Combined Sand Fence Open
This paper introduces a kind of double-row reed–nylon net combined sand barrier. Using the computational fluid dynamics (CFD) method and the Euler–Euler double-fluid model, the new sand fences’ windproof effect and airflow features are sim…
View article: Low-Dose Dexmedetomidine as a Perineural Adjuvant for Postoperative Analgesia: A Randomized Controlled Trial
Low-Dose Dexmedetomidine as a Perineural Adjuvant for Postoperative Analgesia: A Randomized Controlled Trial Open
PurposeDexmedetomidine has been proposed as an additive to local anesthetics to prolong peripheral nerve block duration; however, perineural dexmedetomidine has been associated with an increased risk of bradycardia and hypotension This ran…
View article: Lung Inflation With Hydrogen During the Cold Ischemia Phase Alleviates Lung Ischemia-Reperfusion Injury by Inhibiting Pyroptosis in Rats
Lung Inflation With Hydrogen During the Cold Ischemia Phase Alleviates Lung Ischemia-Reperfusion Injury by Inhibiting Pyroptosis in Rats Open
Background: Lung inflation with hydrogen is an effective method to protect donor lungs from lung ischemia-reperfusion injury (IRI). This study aimed to examine the effect of lung inflation with 3% hydrogen during the cold ischemia phase on…
View article: A systematic review and meta-analysis compare surgical treatment and conservative treatment in patients with cervical spondylotic myelopathy
A systematic review and meta-analysis compare surgical treatment and conservative treatment in patients with cervical spondylotic myelopathy Open
This meta-analysis suggested that surgical treatment may be more advantageous than conservative treatment in patients with CSM. However, these findings should be verified with larger, multi-centered, follow-up, controlled trials.
View article: Application of Transversus Thoracis Muscle Plane Plus Rectus Sheath Block in the Perioperative Pain Management of Cardiac Surgery：Study Protocol of a Randomized Double-blind Controlled Trial
Application of Transversus Thoracis Muscle Plane Plus Rectus Sheath Block in the Perioperative Pain Management of Cardiac Surgery：Study Protocol of a Randomized Double-blind Controlled Trial Open
BackgroundTraditional cardiac surgical anesthesia is characterized by the use of large doses of opioids, accompanied by side effects such as oversedation, respiratory depression, long ventilator duration, prolonged ICU stay, opioid toleran…
View article: Protective effects of molecular hydrogen on lung injury from lung transplantation
Protective effects of molecular hydrogen on lung injury from lung transplantation Open
Lung grafts may experience multiple injuries during lung transplantation, such as warm ischaemia, cold ischaemia, and reperfusion injury. These injuries all contribute to primary graft dysfunction, which is a major cause of morbidity and m…
View article: Expression of LRP8 in gastric cancer and its significance in tumorigenesis
Expression of LRP8 in gastric cancer and its significance in tumorigenesis Open
Background and purpose: Low-density lipoprotein receptor-related protein 8 (LRP8) plays an important role in the development of liver cancer, lung cancer, breast cancer, colorectal cancer and other tumors. This study aimed to explore the e…
View article: cRGD peptide-conjugated polyethylenimine-based lipid nanoparticle for intracellular delivery of siRNA in hepatocarcinoma therapy
cRGD peptide-conjugated polyethylenimine-based lipid nanoparticle for intracellular delivery of siRNA in hepatocarcinoma therapy Open
The effective delivery system plays an important role in the application of siRNA in the antitumor study. However, until now, researches on the delivery systems targeting hepatocarcinoma cells are still being explored. Here we designed and…
View article: Dexmedetomidine inhibits inflammatory response and autophagy through the circLrp1b/miR-27a-3p/Dram2 pathway in a rat model of traumatic brain injury
Dexmedetomidine inhibits inflammatory response and autophagy through the circLrp1b/miR-27a-3p/Dram2 pathway in a rat model of traumatic brain injury Open
Circular RNAs (circRNAs) have a regulatory function on inflammation and autophagy, of which rno-circRNA_010705 (circLrp1b) appears to be significantly up-regulated following traumatic brain injury (TBI). Dexmedetomidine (DEX) shows improve…
View article: A simple, sustained and sufficient calcium regulation scheme during perioperative period for the secondary hyperparathyroidism
A simple, sustained and sufficient calcium regulation scheme during perioperative period for the secondary hyperparathyroidism Open
Background: Patients of secondary hyperparathyroidism (SHPT) with chronic renal failure treated by long-term dialysis have received surgical treatment. The severe complications, especially convulsions caused by severe hypocalcemia, would e…
View article: Corrigendum to “Pseudolaric Acid B Induces Caspase‐Dependent and Caspase‐Independent Apoptosis in U87 Glioblastoma Cells”
Corrigendum to “Pseudolaric Acid B Induces Caspase‐Dependent and Caspase‐Independent Apoptosis in U87 Glioblastoma Cells” Open
[This corrects the article DOI: 10.1155/2012/957568.].
View article: Comparison of Inhibitory Effects of Safflower Decoction and Safflower Injection on Protein and mRNA Expressions of iNOS and IL-1<i>β</i> in LPS-Activated RAW264.7 Cells
Comparison of Inhibitory Effects of Safflower Decoction and Safflower Injection on Protein and mRNA Expressions of iNOS and IL-1<i>β</i> in LPS-Activated RAW264.7 Cells Open
Objective. Safflower has antioxidant and anti-inflammatory activities. The two forms of preparations for safflower which are widely used in China are injection and decoction. The first step of the process for preparing an injection involve…
View article: Delivery of Antisense Oligonucleotide LOR-2501 Using Transferrin-conjugated Polyethylenimine-based Lipid Nanoparticle
Delivery of Antisense Oligonucleotide LOR-2501 Using Transferrin-conjugated Polyethylenimine-based Lipid Nanoparticle Open
Data demonstrated the potential utility of TPSH-LP for oligonucleotide delivery in cancer therapy.
View article: Delivery of antisense oligonucleotide using polyethylenimine-based lipid nanoparticle modified with cell penetrating peptide
Delivery of antisense oligonucleotide using polyethylenimine-based lipid nanoparticle modified with cell penetrating peptide Open
Efficient and stable delivery system of antisense oligonucleotide (ASO) is important and urgently needed. Here, an ASO delivery system, Lp-PPRP, which contains a cationic polymer based on PEI (branched, 25 kDa), named PEI-PC and a palmitic…
View article: Administration of Dexmedetomidine inhibited NLRP3 inflammasome and microglial cell activities in hippocampus of traumatic brain injury rats
Administration of Dexmedetomidine inhibited NLRP3 inflammasome and microglial cell activities in hippocampus of traumatic brain injury rats Open
The abnormally high nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activity is a typical characteristic of traumatic brain injury (TBI). Dexmedetomidine (Dex) is a highly…
View article: Oleic acid derivative of polyethylenimine-functionalized proliposomes for enhancing oral bioavailability of extract of <i>Ginkgo biloba</i>
Oleic acid derivative of polyethylenimine-functionalized proliposomes for enhancing oral bioavailability of extract of <i>Ginkgo biloba</i> Open
The present systematic study focused to investigate the oleic acid derivative of branched polyethylenimine (bPEI-OA)-functionalized proliposomes for improving the oral delivery of extract of Ginkgo biloba (GbE). The GbE proliposomes were p…
View article: Improvement of oral availability of ginseng fruit saponins by a proliposome delivery system containing sodium deoxycholate
Improvement of oral availability of ginseng fruit saponins by a proliposome delivery system containing sodium deoxycholate Open
Ginseng fruit saponins (GFS) extracted from the ginseng fruit are the bioactive triterpenoid saponin components. The aim of the present study was to develop a drug delivery system called proliposome using sodium deoxycholate (NaDC) as a bi…
View article: Comparative pharmacokinetics of a proliposome formulation of Ginkgo biloba extract and Ginaton in rats by a sensitive ultra performance liquid chromatography–tandem mass spectrometry method
Comparative pharmacokinetics of a proliposome formulation of Ginkgo biloba extract and Ginaton in rats by a sensitive ultra performance liquid chromatography–tandem mass spectrometry method Open
As a novel oral drug delivery system, proliposome was applied to improve the solubility of active components of Ginkgo biloba extract (GbE). There are currently few reports focusing on the pharmacokinetic characteristics of proliposome of …