F.B. Bianchi
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View article: Clinical trial: peg‐interferon alfa‐2b and ribavirin for the treatment of genotype‐1 hepatitis C recurrence after liver transplantation
Clinical trial: peg‐interferon alfa‐2b and ribavirin for the treatment of genotype‐1 hepatitis C recurrence after liver transplantation Open
Summary Background Treatment of hepatitis C virus (HCV) recurrence after liver transplantation (LT) is difficult with low response rates. Aim To assess the safety and efficacy of pegylated‐interferon (PEG‐IFN) alfa‐2b + ribavirin (RBV) in …
View article: HCV liver infection and liver steatosis: evidence for indirect mechanisms in genotype 3?
HCV liver infection and liver steatosis: evidence for indirect mechanisms in genotype 3? Open
Summary Background : Hepatitis C virus (HCV) infection is associated with the appearance of liver steatosis. Aim : To search for a correlation between the number of HCV infected hepatocytes and the presence, amount and distribution of stea…
View article: Detailed analysis of the E2–IgM complex in hepatitis C‐related type II mixed cryoglobulinaemia
Detailed analysis of the E2–IgM complex in hepatitis C‐related type II mixed cryoglobulinaemia Open
Summary. Hepatitis C virus (HCV) plays a major role in the induction of type II mixed cryoglobulinaemia (MCII). The role of HCV proteins and virus–host interaction in the pathogenesis of MC remains to be defined. To address this issue, we …
View article: Serum autoantibodies in chronic hepatitis C: Comparison with autoimmune hepatitis and impact on the disease profile
Serum autoantibodies in chronic hepatitis C: Comparison with autoimmune hepatitis and impact on the disease profile Open
Antibodies to nuclei (ANA), smooth muscle (SMA), and liver/kidney microsomes type 1 (anti-LKM1) may occur in chronic hepatitis C. Distinct subspecificities, including ANA with the homogeneous pattern (ANA-H) and SMA with antiactin specific…
View article: Quantification of hepatitis C virus-infected peripheral blood mononuclear cells by in situ reverse transcriptase-polymerase chain reaction
Quantification of hepatitis C virus-infected peripheral blood mononuclear cells by in situ reverse transcriptase-polymerase chain reaction Open
Hepatitis C virus (HCV) is known to infect peripheral blood mononuclear cells (PBMC) of patients with chronic hepatitis C, but the proportion of HCV-infected circulating cells is not detectable by conventional reverse transcriptase-polymer…
View article: Quantitation of hepatitis C virus genome molecules in plasma samples
Quantitation of hepatitis C virus genome molecules in plasma samples Open
A competitive reverse transcription PCR (cRT-PCR)-based assay for the quantitative detection of hepatitis C virus (HCV) viremia was developed, optimized, and applied to the direct molecular analysis of clinical samples from nine patients w…
View article: Serum non-organ specific autoantibodies in human immunodeficiency virus 1 infection.
Serum non-organ specific autoantibodies in human immunodeficiency virus 1 infection. Open
Serum samples from 66 seropositive subjects (56 with a history of intravenous drug abuse), including asymptomatic carriers and patients with persistent generalised lymphadenopathy (PGL), AIDS related complex (ARC), and AIDS, were tested by…
View article: Heterogeneity of antimitochondrial antibodies with the M2-M4 pattern by immunofluorescence as assessed by Western immunoblotting and enzyme linked immunosorbent assay.
Heterogeneity of antimitochondrial antibodies with the M2-M4 pattern by immunofluorescence as assessed by Western immunoblotting and enzyme linked immunosorbent assay. Open
Seventy seven sera with antimitochondrial antibody exhibiting the M2-M4 pattern in immunofluorescence (56 from primary biliary cirrhosis (PBC), 21 from non-primary biliary cirrhosis patients) were studied by the combined use of Western imm…
View article: Precipitating antibodies to rabbit thymus extractable antigens in chronic liver disease: relationship with anti-actin antibodies.
Precipitating antibodies to rabbit thymus extractable antigens in chronic liver disease: relationship with anti-actin antibodies. Open
Using counterimmunoelectrophoresis (CIE), serum antibodies to rabbit thymus extractable antigens were detected in 15% (38/259) of patients with chronic liver disease (CLD) of various aetiologies and 33% (41/124) of patients with miscellane…
View article: Antibodies to cardiac conducting tissue and abnormalities of cardiac conduction in rheumatoid arthritis.
Antibodies to cardiac conducting tissue and abnormalities of cardiac conduction in rheumatoid arthritis. Open
The prevalence of antibodies to cardiac conducting tissue and cardiac conduction electrocardiographic abnormalities were studied in 60 patients with rheumatoid arthritis (RA). Complete or incomplete right bundle branch block (RBBB) was fou…
View article: HBsAg-induced hypertrophic smooth endoplasmic reticulum as a target for liver-kidney microsomal (LKM) antibodies.
HBsAg-induced hypertrophic smooth endoplasmic reticulum as a target for liver-kidney microsomal (LKM) antibodies. Open
To test the hypothesis that LKM antibodies are directed against antigen(s) of the smooth endoplasmic reticulum, liver biopsies from patients with HBsAg chronic hepatitis, rich in liver cells with HBsAg-induced hypertrophic SER, were used. …
View article: Ultrastructural localization and characterization of a ribosomal antibody detected by immunofluorescence in systemic lupus erythematosus.
Ultrastructural localization and characterization of a ribosomal antibody detected by immunofluorescence in systemic lupus erythematosus. Open
The ribosomal antibody detected by tissue immunofluorescence in about 1% of SLE patients was conjugated with peroxidase and its antigen localized by immunoelectronmicroscopy, using rat stomach as substrate. The antibody stained ribosomes o…
View article: Mitochondrial antibodies in primary biliary cirrhosis. V. Ultrastructural localization of the antigen to the inner mitochondrial membrane using a direct peroxidase conjugate.
Mitochondrial antibodies in primary biliary cirrhosis. V. Ultrastructural localization of the antigen to the inner mitochondrial membrane using a direct peroxidase conjugate. Open
The IgG fraction of a primary biliary cirrhosis serum with high titre of mitochondrial antibodies was conjugated with peroxidase and applied to 20 μm cryostat sections of various rat tissues (stomach, kidney and liver). Results at the ultr…
View article: The ultrastructure of Australia antigen in the presence and the absence of specific antibodies.
The ultrastructure of Australia antigen in the presence and the absence of specific antibodies. Open
The technical conditions which allow high resolution electron microscopy of Australia (AU) antigen have been investigated. It was found that uranyl acetate, used as a negative stain, provided reliable and consistent results. AU antigen may…