Félix Viana
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View article: Transduction Mechanisms for Cold Temperature in Mouse Trigeminal and Vagal Ganglion Neurons Innervating Different Peripheral Organs
Transduction Mechanisms for Cold Temperature in Mouse Trigeminal and Vagal Ganglion Neurons Innervating Different Peripheral Organs Open
Aim To elucidate the molecular mechanism of cold sensing by visceral sensory endings, a side‐by‐side characterization of cold‐sensitive (CS) neurons in adult mouse trigeminal (TG) and vagal ganglia (VG) was performed. Methods A combination…
View article: A specialized cold sensing system in the naked mole-rat
A specialized cold sensing system in the naked mole-rat Open
Summary Avoiding cold or seeking warmth are universal animal needs. Homeothermic mammals maintain a constant body temperature despite fluctuating ambient temperatures. One exception is the naked mole-rat which lacks effective thermogenesis…
View article: Piezo2 channels and tactile pain: an intriguing voltage connection
Piezo2 channels and tactile pain: an intriguing voltage connection Open
This scientific commentary refers to ‘Piezo2 voltage-block regulates mechanical pain sensitivity’ by Sánchez-Carranza et al. (https://doi.org/10.1093/brain/awae227).
View article: The ion channel TRPM8 is a direct target of the immunosuppressant rapamycin in primary sensory neurons
The ion channel TRPM8 is a direct target of the immunosuppressant rapamycin in primary sensory neurons Open
Background and Purpose The mechanistic target of rapamycin (mTOR) signalling pathway is a key regulator of cell growth and metabolism. Its deregulation is implicated in several diseases. The macrolide rapamycin, a specific inhibitor of mTO…
View article: The ion channel TRPM8 is a direct target of the immunosuppressant rapamycin in primary sensory neurons
The ion channel TRPM8 is a direct target of the immunosuppressant rapamycin in primary sensory neurons Open
Background and Purpose The mechanistic target of rapamycin (mTOR) signaling pathway is a key regulator of cell growth and metabolism. Its deregulation is implicated in several diseases. The macrolide rapamycin (RAP), a specific inhibitor o…
View article: MODULATION OF TRPM8 TRAFFICKING BY PHOSPHORYLATION
MODULATION OF TRPM8 TRAFFICKING BY PHOSPHORYLATION Open
View article: Sex differences in thermoregulation in mammals: Implications for energy homeostasis
Sex differences in thermoregulation in mammals: Implications for energy homeostasis Open
Thermal homeostasis is a fundamental process in mammals, which allows the maintenance of a constant internal body temperature to ensure an efficient function of cells despite changes in ambient temperature. Increasing evidence has revealed…
View article: Validation of Six Commercial Antibodies for the Detection of Heterologous and Endogenous TRPM8 Ion Channel Expression
Validation of Six Commercial Antibodies for the Detection of Heterologous and Endogenous TRPM8 Ion Channel Expression Open
TRPM8 is a non-selective cation channel expressed in primary sensory neurons and other tissues, including the prostate and urothelium. Its participation in different physiological and pathological processes such as thermoregulation, pain, …
View article: Validation of six commercial antibodies for detection of heterologous and endogenous TRPM8 ion channel expression
Validation of six commercial antibodies for detection of heterologous and endogenous TRPM8 ion channel expression Open
TRPM8 is a non-selective cation channel expressed in primary sensory neurons and other tissues, including prostate and urothelium. Its participation in different physiological and pathological processes such as thermoregulation, pain, itch…
View article: The cold‐sensing ion channel <scp>TRPM8</scp> regulates central and peripheral clockwork and the circadian oscillations of body temperature
The cold‐sensing ion channel <span>TRPM8</span> regulates central and peripheral clockwork and the circadian oscillations of body temperature Open
Aim Physiological functions in mammals show circadian oscillations, synchronized by daily cycles of light and temperature. Central and peripheral clocks participate in this regulation. Since the ion channel TRPM8 is a critical cold sensor,…
View article: TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy
TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy Open
Chemotherapy-induced peripheral neuropathy is a frequent, disabling side effect of anticancer drugs. Oxaliplatin, a platinum compound used in the treatment of advanced colorectal cancer, often leads to a form of chemotherapy-induced periph…
View article: Origins of direction selectivity in the primate retina
Origins of direction selectivity in the primate retina Open
View article: Origins of direction selectivity in the primate retina
Origins of direction selectivity in the primate retina Open
From mouse to primate, there is a striking discontinuity in our current understanding of the neural coding of motion direction. In non-primate mammals, directionally selective cell types and circuits are a signature feature of the retina, …
View article: Constitutive Phosphorylation as a Key Regulator of TRPM8 Channel Function
Constitutive Phosphorylation as a Key Regulator of TRPM8 Channel Function Open
In mammals, environmental cold sensing conducted by peripheral cold thermoreceptor neurons mostly depends on TRPM8, an ion channel that has evolved to become the main molecular cold transducer. This TRP channel is activated by cold, coolin…
View article: Transduction mechanisms for cold temperature in mouse trigeminal and vagal ganglion neurons innervating different peripheral organs
Transduction mechanisms for cold temperature in mouse trigeminal and vagal ganglion neurons innervating different peripheral organs Open
Thermal signals are critical elements in the operation of interoceptive and exteroceptive neural circuits, essential for triggering thermally-driven reflexes and conscious behaviors. A fraction of cutaneous and visceral sensory endings are…
View article: Early postnatal development of thyrotropin-releasing hormone (TRH) expression, TRH receptor binding, and TRH responses in neurons of rat brainstem
Early postnatal development of thyrotropin-releasing hormone (TRH) expression, TRH receptor binding, and TRH responses in neurons of rat brainstem Open
We investigated the postnatal development of the thyrotropin-releasing hormone (TRH)-containing raphe system in the brainstem of neonatal rats. Postnatal changes in TRH expression in nucleus (n.) raphe obscurus (ROb) and n. raphe pallidus …
View article: Piezo2 Mediates Low-Threshold Mechanically Evoked Pain in the Cornea
Piezo2 Mediates Low-Threshold Mechanically Evoked Pain in the Cornea Open
Mammalian Piezo2 channels are essential for transduction of innocuous mechanical forces by proprioceptors and cutaneous touch receptors. In contrast, mechanical responses of somatosensory nociceptor neurons evoking pain, remain intact or a…
View article: Detecting Warm Temperatures Is a Cool Kind of Thing
Detecting Warm Temperatures Is a Cool Kind of Thing Open
View article: The Immunosuppressant Macrolide Tacrolimus Activates Cold-Sensing TRPM8 Channels
The Immunosuppressant Macrolide Tacrolimus Activates Cold-Sensing TRPM8 Channels Open
TRPM8 is a polymodal, nonselective cation channel activated by cold temperature and cooling agents that plays a critical role in the detection of environmental cold. We found that TRPM8 is a pharmacological target of tacrolimus (FK506), a …
View article: Cone type specific dendritic calcium signaling in the blue-yellow color opponent ganglion cells of the primate retina
Cone type specific dendritic calcium signaling in the blue-yellow color opponent ganglion cells of the primate retina Open
View article: Morphological and functional changes in TRPM8‐expressing corneal cold thermoreceptor neurons during aging and their impact on tearing in mice
Morphological and functional changes in TRPM8‐expressing corneal cold thermoreceptor neurons during aging and their impact on tearing in mice Open
Morphological and functional alterations of peripheral somatosensory neurons during the aging process lead to a decline of somatosensory perception. Here, we analyze the changes occurring with aging in trigeminal ganglion (TG), TRPM8‐expre…
View article: Deletion of the Cold Thermoreceptor TRPM8 Increases Heat Loss and Food Intake Leading to Reduced Body Temperature and Obesity in Mice
Deletion of the Cold Thermoreceptor TRPM8 Increases Heat Loss and Food Intake Leading to Reduced Body Temperature and Obesity in Mice Open
The coupling of energy homeostasis to thermoregulation is essential to maintain homeothermy in changing external environments. We studied the role of the cold thermoreceptor TRPM8 in this interplay in mice of both sexes. We demonstrate tha…
View article: New Insight in Cold Pain: Role of Ion Channels, Modulation, and Clinical Perspectives
New Insight in Cold Pain: Role of Ion Channels, Modulation, and Clinical Perspectives Open
Cold temperature detection involves the process of sensory transduction in cutaneous primary sensory nerve terminals, which converts thermal stimuli into depolarizations of the membrane. This transformation into electrical signals is follo…
View article: TRPA1 channels: molecular sentinels of cellular stress and tissue damage
TRPA1 channels: molecular sentinels of cellular stress and tissue damage Open
TRPA1 is a non‐selective cation channel expressed in mammalian peripheral pain receptors, with a major role in chemonociception. TRPA1 has also been implicated in noxious cold and mechanical pain sensation. TRPA1 has an ancient origin and …
View article: Chemical structure of the drugs with TRPM8 antagonist activity used in this study.
Chemical structure of the drugs with TRPM8 antagonist activity used in this study. Open
Chemical structure of the drugs with TRPM8 antagonist activity used in this study.
View article: TRPM8 is a neuronal osmosensor that regulates eye blinking in mice
TRPM8 is a neuronal osmosensor that regulates eye blinking in mice Open