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View article: Computational identification of microbial metabolites as potential inhibitors of mosquito juvenile hormone binding protein for vector control
Computational identification of microbial metabolites as potential inhibitors of mosquito juvenile hormone binding protein for vector control Open
A group of acyclic sesquiterpenoids, that form the Juvenile hormone is crucial in the developmental physiology of insects. Aedes aegypti is crucial in spreading fatal diseases such as dengue, and dengue hemorrhagic fever. The mosquito unde…
View article: Pathological Response Assessment following Long Course Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer: A Single Institutional Cohort Study
Pathological Response Assessment following Long Course Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer: A Single Institutional Cohort Study Open
Introduction: Neoadjuvant chemoradiation and Total Mesorectal Excision (TME) have shown pathological complete response (pCR) rates of 15-27%. The pCR is a significant predictor of survival. The Mandard Tumour Regression Grading (TRG) syste…
View article: Prospective evaluation of small bowel dose and acute gastrointestinal toxicity during pelvic radiotherapy for gynaecologic malignancies
Prospective evaluation of small bowel dose and acute gastrointestinal toxicity during pelvic radiotherapy for gynaecologic malignancies Open
Introduction: Acute gastrointestinal (GI) toxicity is common in patients receiving pelvic radiotherapy (RT) and the small bowel (SB) is a dose-limiting organ at risk. There is a quandary in the dose constraints for SB while using intensity…
View article: Lumbosacral plexopathy after short-course neoadjuvant radiotherapy for rectal cancer: A case report
Lumbosacral plexopathy after short-course neoadjuvant radiotherapy for rectal cancer: A case report Open
Radiation-induced lumbosacral plexopathy (RILSP) is a rare complication associated with pelvic radiotherapy. Literature is scant about the incidence of RILSP after a neoadjuvant short-course radiotherapy (RT) in rectal cancer. In this repo…
View article: Stereotactic Body Radiation Therapy (SBRT) in prostate cancer in the presence of hip prosthesis – is it a contraindication? A narrative review
Stereotactic Body Radiation Therapy (SBRT) in prostate cancer in the presence of hip prosthesis – is it a contraindication? A narrative review Open
Hip replacement is a common orthopedic surgery in the aging population. With the rising incidence of prostate cancer, metallic hip prosthetics can cause considerable beam hardening and streak artifacts, leading to difficulty in identifying…
View article: Cardiac migration of an implanted hepatic fiducial marker used for stereotactic body radiation therapy - A case report
Cardiac migration of an implanted hepatic fiducial marker used for stereotactic body radiation therapy - A case report Open
Stereotactic body radiation therapy (SBRT) has been increasingly used to treat liver malignancies because large doses of radiation can be delivered precisely to the target with a rapid dose falloff. Real-time tracking of implanted fiducial…
View article: Hypofractionated Radiotherapy for Hematologic Malignancies during the COVID-19 Pandemic and Beyond
Hypofractionated Radiotherapy for Hematologic Malignancies during the COVID-19 Pandemic and Beyond Open
Purpose: Radiotherapy is integral in the management of hematological malignancies (HM). Standard radiotherapy dose fractionation regimens range between 20 and 50 Gy in 10–25 fractions over 2–5 weeks. This study presents the outcomes of pat…
View article: Hypofractionated Radiotherapy for Hematologic Malignancies during the COVID-19 Pandemic and Beyond
Hypofractionated Radiotherapy for Hematologic Malignancies during the COVID-19 Pandemic and Beyond Open
Purpose Radiotherapy is integral in the management of hematological malignancies (HM). Standard radiotherapy dose fractionation regimens range between 20-50 Gy in 10-25 fractions over 2-5 weeks. This study presents the outcomes of patients…
View article: Dosimetric comparison of irradiated small bowel volume with intensity modulated radiotherapy and volumetric modulated arc therapy in adjuvant pelvic radiation therapy for endometrial carcinoma
Dosimetric comparison of irradiated small bowel volume with intensity modulated radiotherapy and volumetric modulated arc therapy in adjuvant pelvic radiation therapy for endometrial carcinoma Open
Newer treatment techniques help in reducing dose to small bowel (SB) which is an organ at risk (OAR) for pelvic radiotherapy (RT). However, instead of SB, bowel bag is contoured routinely and constraints are given. In this retrospective ca…
View article: Radiotherapy for successful symptom control in recurrent refractory endometriosis: A case report
Radiotherapy for successful symptom control in recurrent refractory endometriosis: A case report Open
Endometriosis is a benign gynecological condition which induces a chronic inflammatory process, characterized by the presence of endometrium-like tissue outside the uterus. Treatment options for endometriosis include medical, surgical, or …
View article: Relationship of irradiated bone marrow volume and neutropenia in patients undergoing concurrent chemoradiation therapy for cervical cancer
Relationship of irradiated bone marrow volume and neutropenia in patients undergoing concurrent chemoradiation therapy for cervical cancer Open
Introduction: Concurrent chemoradiation therapy (CCRT) is the standard of care in the management of cervical cancer (International Federation of Gynecology and Obstetrics [FIGO] 2008 Stages IB2-IVA). Apart from the myelotoxic effects of ch…
View article: Updates on systemic therapy for cervical cancer
Updates on systemic therapy for cervical cancer Open
Cervical cancer is one of the most common cancers in the world both in terms of incidence and mortality, more so important in low- and middle-income countries. Surgery and radiotherapy remain the backbone of treatment for non-metastatic ce…
View article: Efficacy of vaginal dilator use in preventing vaginal stenosis among cervical and endometrial cancer patients underwent radiotherapy
Efficacy of vaginal dilator use in preventing vaginal stenosis among cervical and endometrial cancer patients underwent radiotherapy Open
Background: Vaginal dilators (VD) are effective in the prevention of vaginal stenosis in patients undergoing pelvic radiotherapy for gynaecological malignancies. This study was aimed to assess the efficacy of VD use in preventing post radi…
View article: Dosimetric comparison of organs at risk with three-dimensional conformal radiation, intensity-modulated radiation and volumetric-modulated arc therapy in cervical cancer: a cross sectional study
Dosimetric comparison of organs at risk with three-dimensional conformal radiation, intensity-modulated radiation and volumetric-modulated arc therapy in cervical cancer: a cross sectional study Open
Three-dimensional conformal radiation therapy (3DCRT), intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) are the three main radiotherapy treatment techniques for cervical cancer. Whether either techni…
View article: Retrospective Analysis of Early Impact of COVID-19 on Systemic Cancer Treatment—A Pilot Study
Retrospective Analysis of Early Impact of COVID-19 on Systemic Cancer Treatment—A Pilot Study Open
Introduction Cancer care during the coronavirus disease 2019 (COVID-19) pandemic is challenging as the patients are at an increased risk of developing complications compared with the general population. Objectives This study was conducted …