Francesca Frau
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View article: Non-Linear Association Between Phase Angle and Body Fat in a Sample of US Adults
Non-Linear Association Between Phase Angle and Body Fat in a Sample of US Adults Open
Phase angle (PhA) is a widely used bioimpedance index associated with cell mass, membrane integrity, skeletal muscle mass and quality, and body fluid distribution. This study aims to investigate the relationship between PhA and body fat, w…
View article: Phase angle and vector analysis in the evaluation of body composition in sarcopenic obesity: a systematic review
Phase angle and vector analysis in the evaluation of body composition in sarcopenic obesity: a systematic review Open
Research is still quite heterogeneous in terms of methods and diagnostic procedures, which limits the comparability of the results. However, the observed tendencies confirm the suitability of PhA for recognizing the reduced muscle mass ass…
View article: Enhancing marine protected areas with effective ecological and environmental data integration
Enhancing marine protected areas with effective ecological and environmental data integration Open
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View article: Non-Linear Association Between Phase Angle and Body Fat
Non-Linear Association Between Phase Angle and Body Fat Open
Phase angle (PhA) is a widely used bioimpedance index associated with cell mass, membrane integrity, skeletal muscle mass and quality, and body fluid distribution. However, its relationship with body fat is unclear, with inconsistent findi…
View article: Deciphering differential biomarkers for anti-interleukin-6 receptor and anti-tumour necrosis factor-α treatment response in rheumatoid arthritis by multiomics analysis
Deciphering differential biomarkers for anti-interleukin-6 receptor and anti-tumour necrosis factor-α treatment response in rheumatoid arthritis by multiomics analysis Open
Objective To identify blood-based predictive and pharmacodynamic biomarkers at different timepoints in patients with active rheumatoid arthritis (RA) treated with anti-interleukin-6 receptor (anti-IL-6R) and anti-tumour necrosis factor-α (…
View article: Uncovering New Therapeutic Targets for Amyotrophic Lateral Sclerosis and Neurological Diseases Using Real‐World Data
Uncovering New Therapeutic Targets for Amyotrophic Lateral Sclerosis and Neurological Diseases Using Real‐World Data Open
Although attractive for relevance to real‐world scenarios, real‐world data (RWD) is typically used for drug repurposing and not therapeutic target discovery. Repurposing studies have identified few effective options in neurological disease…
View article: Enhancing Marine Protected Areas with Effective Ecological and Environmental Data Integration
Enhancing Marine Protected Areas with Effective Ecological and Environmental Data Integration Open
View article: Learning good therapeutic targets in ALS, neurodegeneration, using observational studies
Learning good therapeutic targets in ALS, neurodegeneration, using observational studies Open
Analysis of real-world data (RWD) is attractive for its applicability to real-world scenarios but RWD is typically used for drug repurposing and not therapeutic target discovery. Repurposing studies have identified few effective options in…
View article: Disease progression strikingly differs in research and real-world Parkinson’s populations
Disease progression strikingly differs in research and real-world Parkinson’s populations Open
Characterization of Parkinson’s disease (PD) progression using real-world evidence could guide clinical trial design and identify subpopulations. Efforts to curate research populations, the increasing availability of real-world data, and a…
View article: Disease progression strikingly differs in research and real-world Parkinson's populations
Disease progression strikingly differs in research and real-world Parkinson's populations Open
Characterization of Parkinson's disease (PD) progression using real-world evidence could guide clinical trial design and identify subpopulations. Efforts to curate research populations, the increasing availability of real-world data and re…
View article: Multiple indices on different habitats and descriptors provide consistent assessments of environmental quality in a marine protected area
Multiple indices on different habitats and descriptors provide consistent assessments of environmental quality in a marine protected area Open
In the last decades, climate change and human pressures have increasingly and dramatically impacted the ocean worldwide, calling for urgent actions to safeguard coastal marine ecosystems. The European Commission, in particular, has set amb…
View article: Peer Review #2 of "Sea urchin harvest inside marine protected areas: an opportunity to investigate the effects of exploitation where trophic upgrading is achieved (v0.1)"
Peer Review #2 of "Sea urchin harvest inside marine protected areas: an opportunity to investigate the effects of exploitation where trophic upgrading is achieved (v0.1)" Open
urchin populations and the assessment of MPA effects on P. lividus populations would be crucial to guide management decisions on regulating harvest permits.Overall, the need to ban sea urchin harvest in the MPAs to avoid extreme reductions…
View article: Sea urchin harvest inside marine protected areas: an opportunity to investigate the effects of exploitation where trophic upgrading is achieved
Sea urchin harvest inside marine protected areas: an opportunity to investigate the effects of exploitation where trophic upgrading is achieved Open
Background Marine protected areas (MPAs) usually have both positive effects of protection for the fisheries’ target species and indirect negative effects for sea urchins. Moreover, often in MPAs sea urchin human harvest is restricted, but …
View article: Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study
Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study Open
Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N = 2,111) underwent a 2-h 75-g oral glucose tolerance test (OGTT) at baseline and 48 mo…
View article: Loggerhead sea turtle, Caretta caretta, presence and its exposure to floating marine litter in the Sardinia Channel and the Strait of Sicily: results from seven years of monitoring using ferry as platform of observation
Loggerhead sea turtle, Caretta caretta, presence and its exposure to floating marine litter in the Sardinia Channel and the Strait of Sicily: results from seven years of monitoring using ferry as platform of observation Open
The loggerhead turtle is the most common sea turtle species in the Mediterranean Sea. Despite relevant research efforts, information of its distribution is still scarce, particularly in the open sea where they may be exposed to different t…
View article: Accelerating diagnosis of Parkinson’s disease through risk prediction
Accelerating diagnosis of Parkinson’s disease through risk prediction Open
View article: Animal Forest Mortality: Following the Consequences of a Gorgonian Coral Loss on a Mediterranean Coralligenous Assemblage
Animal Forest Mortality: Following the Consequences of a Gorgonian Coral Loss on a Mediterranean Coralligenous Assemblage Open
In this work, the consequences of a local gorgonian coral mortality on the whole coralligenous assemblage were studied. A Before/After-Control/Impact sampling design was used: the structure of the coralligenous assemblage was compared befo…
View article: Environmental Engineering Techniques to Restore Degraded Posidonia oceanica Meadows
Environmental Engineering Techniques to Restore Degraded Posidonia oceanica Meadows Open
Seagrass planting techniques have shown to be an effective tool for restoring degraded meadows and ecosystem function. In the Mediterranean Sea, most restoration efforts have been addressed to the endemic seagrass Posidonia oceanica, but c…
View article: Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study
Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study Open
OBJECTIVE We investigated the processes underlying glycemic deterioration in type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS A total of 732 recently diagnosed patients with T2D from the Innovative Medicines Initiative Diabetes Research …
View article: A reference map of potential determinants for the human serum metabolome
A reference map of potential determinants for the human serum metabolome Open
View article: Effort data from the FLT Mediterranean Network 2008-2018
Effort data from the FLT Mediterranean Network 2008-2018 Open
Effort data used for the analysis presented in the manuscript "Trends in summer presence of fin whales in the Western Mediterranean Sea Region: new insights from a long-term monitoring program" - submitted for publication on PeerJ. Shape f…
View article: Effort data from the FLT Mediterranean Network 2008-2018
Effort data from the FLT Mediterranean Network 2008-2018 Open
Effort data used for the analysis presented in the manuscript "Trends in summer presence of fin whales in the Western Mediterranean Sea Region: new insights from a long-term monitoring program" - submitted for publication on PeerJ. Shape f…
View article: Genome-Wide Polygenic Risk Score Identifies Individuals at Elevated Parkinson’s Disease Risk
Genome-Wide Polygenic Risk Score Identifies Individuals at Elevated Parkinson’s Disease Risk Open
SUMMARY Parkinson’s Disease (PD) is the second most common and fastest-growing neurological disorder. Polygenic Risk Scores (PRS) using hundreds to thousands of PD-associated variants support polygenic heritability. Here, for the first tim…
View article: Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts
Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts Open
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious health complications in individuals with and without type 2 diabetes (T2D). Early diagnosis of NAFLD is important, as this can help prevent irreve…
View article: Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study
Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study Open
Background Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious health complications in type 2 diabetes (T2D) and beyond. Early diagnosis of NAFLD is important, as this can help prevent irreversible damage to th…
View article: Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration
Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration Open
View article: Variation in the Plasma Membrane Monoamine Transporter (PMAT) (Encoded by <i>SLC29A4</i> ) and Organic Cation Transporter 1 (OCT1) (Encoded by <i>SLC22A1</i> ) and Gastrointestinal Intolerance to Metformin in Type 2 Diabetes: An IMI DIRECT Study
Variation in the Plasma Membrane Monoamine Transporter (PMAT) (Encoded by <i>SLC29A4</i> ) and Organic Cation Transporter 1 (OCT1) (Encoded by <i>SLC22A1</i> ) and Gastrointestinal Intolerance to Metformin in Type 2 Diabetes: An IMI DIRECT Study Open
OBJECTIVE Gastrointestinal adverse effects occur in 20–30% of patients with metformin-treated type 2 diabetes, leading to premature discontinuation in 5–10% of the cases. Gastrointestinal intolerance may reflect localized high concentratio…
View article: Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension
Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension Open
Recent genetic studies have identified alleles associated with opposite effects on adiposity and risk of type 2 diabetes. We aimed to identify more of these variants and test the hypothesis that such favorable adiposity alleles are associa…
View article: Type-2 diabetes-associated variants with cross-trait relevance: Post-GWAs strategies for biological function interpretation
Type-2 diabetes-associated variants with cross-trait relevance: Post-GWAs strategies for biological function interpretation Open
Genome-wide association studies (GWAs) for type 2 diabetes (T2D) have been successful in identifying many loci with robust association signals. Nevertheless, there is a clear need for post-GWAs strategies to understand mechanism of action …
View article: The LIFE+ project "RES MARIS - Recovering Endangered habitatS in the Capo Carbonara MARIne area, Sardinia": First results
The LIFE+ project "RES MARIS - Recovering Endangered habitatS in the Capo Carbonara MARIne area, Sardinia": First results Open
RES MARIS is an environmental protection project cofinanced by the European Union through the LIFE + Nature and Biodiversity Programme. The project aims at the conservation and recovery of marine and terrestrial ecosystems, included in the…