Federica Piani
YOU?
Author Swipe
View article: New Insights into Uric Acid Metabolism in the Pathophysiology of Ischaemic Heart Disease
New Insights into Uric Acid Metabolism in the Pathophysiology of Ischaemic Heart Disease Open
The role of hyperuricaemia as an independent cardiovascular risk factor remains controversial and subject to debate. Nonetheless, multiple studies have highlighted the central role of uric acid (UA) in conditions such as hypertension, meta…
View article: Importance of STAT3 signaling in preeclampsia (Review)
Importance of STAT3 signaling in preeclampsia (Review) Open
Placentation is a key process that is tightly regulated that ensures the normal placenta and fetal development. Preeclampsia (PE) is a hypertensive pregnancy‑associated disorder characterized by increased oxidative stress and inflammation.…
View article: Sphingosine-1-Phosphate, a Marker of Endothelial Injury and Disease Severity in Preeclampsia
Sphingosine-1-Phosphate, a Marker of Endothelial Injury and Disease Severity in Preeclampsia Open
BACKGROUND: Preeclampsia is a hypertensive pregnancy disorder marked by endothelial damage. Healthy endothelium is covered by a protective glycocalyx layer, which, when degraded, releases detectable products into the blood. Sphingosine-1-p…
View article: Editorial: Gestational diabetes: where are we and where are we going?
Editorial: Gestational diabetes: where are we and where are we going? Open
NA
View article: The Role of Xanthine Oxidase in Pregnancy Complications: A Systematic Review
The Role of Xanthine Oxidase in Pregnancy Complications: A Systematic Review Open
Xanthine oxidoreductase (XOR) is an enzyme involved in the oxidation of hypoxanthine and xanthine to uric acid. XOR has two isoforms: xanthine dehydrogenase and xanthine oxidase (XO). XO plays a major role in oxidative stress, causing the …
View article: Causal relationship between serum uric acid and cardiovascular disease: A Mendelian randomization study
Causal relationship between serum uric acid and cardiovascular disease: A Mendelian randomization study Open
View article: Long-term reduction of endothelial glycocalyx thickness 6 years after preeclampsia
Long-term reduction of endothelial glycocalyx thickness 6 years after preeclampsia Open
Objective.The endothelial glycocalyx (EG) is a complex structure composed of proteoglycans, glycoproteins, and glycolip-
View article: Gender-Specific Medicine in the European Society of Cardiology Guidelines from 2018 to 2023: Where Are We Going?
Gender-Specific Medicine in the European Society of Cardiology Guidelines from 2018 to 2023: Where Are We Going? Open
Background/Objectives: Evidence-based medicine (EBM) shapes most clinical guidelines. Although the advent of EBM marked a significant advancement, failure to include sex differences in the study design and analysis of most trials leads to …
View article: Role of SLC7A11/xCT in Ovarian Cancer
Role of SLC7A11/xCT in Ovarian Cancer Open
Ovarian cancer is one of the most dangerous gynecologic cancers worldwide and has a high fatality rate due to diagnosis at an advanced stage of the disease as well as a high recurrence rate due to the occurrence of chemotherapy resistance.…
View article: Correction to: When pregnancy-associated hypertriglyceridemia goes above and beyond the risk of pancreatitis
Correction to: When pregnancy-associated hypertriglyceridemia goes above and beyond the risk of pancreatitis Open
View article: Role of CD93 in Health and Disease
Role of CD93 in Health and Disease Open
CD93 (also known as complement protein 1 q subcomponent receptor C1qR1 or C1qRp), is a transmembrane glycoprotein encoded by a gene located on 20p11.21 and composed of 652 amino acids. CD93 can be present in two forms: soluble (sCD93) and …
View article: Modulation of NRF2/KEAP1 Signaling in Preeclampsia
Modulation of NRF2/KEAP1 Signaling in Preeclampsia Open
Placentation is a key and tightly regulated process that ensures the normal development of the placenta and fetal growth. Preeclampsia (PE) is a hypertensive pregnancy-related disorder involving about 5–8% of all pregnancies and clinically…
View article: Serum uric acid to creatinine ratio and risk of preeclampsia and adverse pregnancy outcomes
Serum uric acid to creatinine ratio and risk of preeclampsia and adverse pregnancy outcomes Open
Objective: Preeclampsia is one of the most severe diseases among the hypertensive disorders of pregnancy (HDP) and the leading cause of maternal and fetal morbidity and mortality. It is of crucial importance to early identify women at a hi…
View article: Diagnostic and Prognostic Role of CD93 in Cardiovascular Disease: A Systematic Review
Diagnostic and Prognostic Role of CD93 in Cardiovascular Disease: A Systematic Review Open
Introduction. Cluster of Differentiation (CD) 93 (also known as complement protein 1 q subcomponent receptor C1qR1 or C1qRp) is a transmembrane glycoprotein that can also be present in a soluble (sCD93) form. Recent studies have investigat…
View article: β1-Integrin blockade prevents podocyte injury in experimental models of minimal change disease
β1-Integrin blockade prevents podocyte injury in experimental models of minimal change disease Open
Podocyte β1 integrin activation is an upstream mediator of FAK phosphorylation and podocyte injury in models of MCD-like injury.
View article: Uric Acid and Chronic Kidney Disease: Still More to Do
Uric Acid and Chronic Kidney Disease: Still More to Do Open
View article: β1-Integrin blockade prevents podocyte injury in experimental models of minimal change disease
β1-Integrin blockade prevents podocyte injury in experimental models of minimal change disease Open
Introduction: Activation of the focal adhesion kinase (FAK) in podocytes is involved in the pathogenesis of minimal change disease (MCD), but the pathway leading to its activation in this disease is unknown. Here, we tested whether podocyt…
View article: Statin therapy may protect against acute kidney injury in patients hospitalized for interstitial SARS-CoV2 pneumonia
Statin therapy may protect against acute kidney injury in patients hospitalized for interstitial SARS-CoV2 pneumonia Open
View article: The Gut Microbiota and Vascular Aging: A State-of-the-Art and Systematic Review of the Literature
The Gut Microbiota and Vascular Aging: A State-of-the-Art and Systematic Review of the Literature Open
The gut microbiota is a critical regulator of human physiology, deleterious changes to its composition and function (dysbiosis) have been linked to the development and progression of cardiovascular diseases. Vascular ageing (VA) is a proce…
View article: Plasma levels of carboxylic acids are markers of early kidney dysfunction in young people with type 1 diabetes
Plasma levels of carboxylic acids are markers of early kidney dysfunction in young people with type 1 diabetes Open
View article: Aminoaciduria and metabolic dysregulation during diabetic ketoacidosis: Results from the diabetic kidney alarm (DKA) study
Aminoaciduria and metabolic dysregulation during diabetic ketoacidosis: Results from the diabetic kidney alarm (DKA) study Open
View article: Hyperuricemia and chronic kidney disease: to treat or not to treat
Hyperuricemia and chronic kidney disease: to treat or not to treat Open
Hyperuricemia is common in chronic kidney disease (CKD) and may be present in 50% of patients presenting for dialysis. Hyperuricemia can be secondary to impaired glomerular filtration rate (GFR) that occurs in CKD. However, hyperuricemia c…
View article: Molecular Mechanisms of Proteinuria in Minimal Change Disease
Molecular Mechanisms of Proteinuria in Minimal Change Disease Open
Minimal change disease (MCD) is the most common type of idiopathic nephrotic syndrome in childhood and represents about 15% cases in adults. It is characterized by massive proteinuria, edema, hypoalbuminemia, and podocyte foot process effa…
View article: Minimal Change Disease Is Associated With Endothelial Glycocalyx Degradation and Endothelial Activation
Minimal Change Disease Is Associated With Endothelial Glycocalyx Degradation and Endothelial Activation Open
View article: Prevalence and Outcomes Associated with Hyperuricemia in Hospitalized Patients with COVID-19
Prevalence and Outcomes Associated with Hyperuricemia in Hospitalized Patients with COVID-19 Open
Introduction: Coronavirus 2019 (COVID-19) can increase catabolism and result in hyperuricemia. Uric acid (UA) potentially causes kidney damage by alteration of renal autoregulation, inhibition of endothelial cell proliferatio…
View article: The Role of Uric Acid in Acute and Chronic Coronary Syndromes
The Role of Uric Acid in Acute and Chronic Coronary Syndromes Open
Uric acid (UA) is the final product of the catabolism of endogenous and exogenous purine nucleotides. While its association with articular gout and kidney disease has been known for a long time, new data have demonstrated that UA is also r…
View article: Uric Acid and Risk of Cardiovascular Disease: A Question of Start and Finish
Uric Acid and Risk of Cardiovascular Disease: A Question of Start and Finish Open
Uric acid (UA) is the final product of purine metabolism and its increase in the circulating blood defines the presence of hyperuricemia commonly considered as a concentration of UA in serum above the threshold level of 7 mg/dL in men and …
View article: Surprises in cardiology: efficacy of gliflozines in heart failure even in the absence of diabetes
Surprises in cardiology: efficacy of gliflozines in heart failure even in the absence of diabetes Open
It is now well-established that the therapy of type II diabetes mellitus has undergone a radical change in the past 15 years: countless innovative drugs, such as SGLT2I, able to guarantee an optimization of glycaemic control without causin…
View article: Tubular injury in diabetic ketoacidosis: Results from the diabetic kidney alarm study
Tubular injury in diabetic ketoacidosis: Results from the diabetic kidney alarm study Open
DKA was characterized by tubular injury, and the degree of injury associated with elevated copeptin and SUA. Tubular injury biomarkers, copeptin and SUA may be able to predict AKI in DKA.
View article: Acute Kidney Injury in Pediatric Diabetic Kidney Disease
Acute Kidney Injury in Pediatric Diabetic Kidney Disease Open
Diabetic kidney disease (DKD) is a common complication of type 1 and 2 diabetes and often presents during adolescence and young adulthood. Given the growing incidence of both type 1 and type 2 diabetes in children and adolescents, DKD repr…