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View article: USP7 at the Crossroads of Ubiquitin Signaling, Cell Cycle, and Tumorigenesis
USP7 at the Crossroads of Ubiquitin Signaling, Cell Cycle, and Tumorigenesis Open
Protein homeostasis is a dynamic process essential for cellular function and survival, tightly controlled by the ubiquitin–proteasome system. Within this system, ubiquitin-specific protease 7 (USP7) plays a key role as a deubiquitinating e…
View article: PDE4D: A Multipurpose Pharmacological Target
PDE4D: A Multipurpose Pharmacological Target Open
Phosphodiesterase 4 (PDE4) enzymes catalyze cyclic adenosine monophosphate (cAMP) hydrolysis and are involved in a variety of physiological processes, including brain function, monocyte and macrophage activation, and neutrophil infiltratio…
View article: Investigations of Antioxidant and Anti-Cancer Activities of 5-Aminopyrazole Derivatives
Investigations of Antioxidant and Anti-Cancer Activities of 5-Aminopyrazole Derivatives Open
To further extend the structure-activity relationships (SARs) of 5-aminopyrazoles (5APs) and identify novel compounds able to interfere with inflammation, oxidative stress, and tumorigenesis, 5APs 1–4 have been designed and prepared. Some …
View article: Insights into the Pharmacological Activity of the Imidazo−Pyrazole Scaffold
Insights into the Pharmacological Activity of the Imidazo−Pyrazole Scaffold Open
In previous studies, we synthesized different imidazo−pyrazoles 1 and 2 with interesting anticancer, anti‐angiogenic and anti‐inflammatory activities. To further extend the structure‐activity relationships of imidazo−pyrazole scaffold and …
View article: Scouting Different Phosphodiesterase 4 Inhibitor Chemotypes in Silico To Guide the Design of Anti‐inflammatory/Antioxidant Agents
Scouting Different Phosphodiesterase 4 Inhibitor Chemotypes in Silico To Guide the Design of Anti‐inflammatory/Antioxidant Agents Open
During the last years, we developed a large library of new selective phosphodiesterase 4D inhibitors, maintaining the catechol portion of the well‐known PDE4 inhibitor Rolipram, featuring different substitutions in place of the lactam grou…
View article: New Series of Pyrazoles and Imidazo-Pyrazoles Targeting Different Cancer and Inflammation Pathways
New Series of Pyrazoles and Imidazo-Pyrazoles Targeting Different Cancer and Inflammation Pathways Open
(1) Background: different previously synthesized pyrazoles and imidazo-pyrazoles showed interesting anti-angiogenic action, being able to interfere with ERK1/2, AKT and p38MAPK phosphorylation in different manners and with different potenc…
View article: Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors
Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors Open
View article: L'alfabeto con meno parabaleni. Una proposta per un'educazione alla letto-scrittura in italiano L2 con giovani e adulti scarsamente o non alfabetizzati nella L1 e scarsamente o non scolarizzati.
L'alfabeto con meno parabaleni. Una proposta per un'educazione alla letto-scrittura in italiano L2 con giovani e adulti scarsamente o non alfabetizzati nella L1 e scarsamente o non scolarizzati. Open
The systems for hospitality and social inclusion of migrants in Italy offer a privileged point of view for debating about language education policies. The challenge of literacy education and second language learning for young people and ad…
View article: Pyrazolyl-Ureas as Interesting Scaffold in Medicinal Chemistry
Pyrazolyl-Ureas as Interesting Scaffold in Medicinal Chemistry Open
The pyrazole nucleus has long been known as a privileged scaffold in the synthesis of biologically active compounds. Within the numerous pyrazole derivatives developed as potential drugs, this review is focused on molecules characterized b…
View article: Insight into GEBR-32a: Chiral Resolution, Absolute Configuration and Enantiopreference in PDE4D Inhibition
Insight into GEBR-32a: Chiral Resolution, Absolute Configuration and Enantiopreference in PDE4D Inhibition Open
Alzheimer’s disease is the most common type of dementia, affecting millions of people worldwide. One of its main consequences is memory loss, which is related to downstream effectors of cyclic adenosine monophosphate (cAMP). A well-establi…
View article: New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets
New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets Open
Several anti-inflammatory agents based on pyrazole and imidazopyrazole scaffolds and a large library of substituted catechol PDE4D inhibitors were reported by us in the recent past. To obtain new molecules potentially able to act on differ…
View article: Chiral Resolution of a New Agent against Memory Impairment Connected to Neurodegenerative Diseases
Chiral Resolution of a New Agent against Memory Impairment Connected to Neurodegenerative Diseases Open
Nowadays, the incidence of neurodegenerative diseases is increasing, and these disorders will become one of the main challenges for medicine and public health in future years. Particularly, memory loss characterizes many neurodegenerative …