Federico Baldi
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View article: Three Cases of Human Babesiosis, Italy, 2017–2020
Three Cases of Human Babesiosis, Italy, 2017–2020 Open
We report 3 cases of babesiosis in Italy caused by Babesia species that are rarely reported in humans. The circulation of Babesia spp. among vectors, animals, and humans might be more common than previously thought, and babesiosis might be…
View article: Triple Combination Therapy With 2 Antivirals and Monoclonal Antibodies for Persistent or Relapsed Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Patients
Triple Combination Therapy With 2 Antivirals and Monoclonal Antibodies for Persistent or Relapsed Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Patients Open
Background Severely immunocompromised patients are at risk for prolonged or relapsed Coronavirus Disease 2019 (COVID-19), leading to increased morbidity and mortality. We aimed to evaluate efficacy and safety of combination treatment in im…
View article: Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for COVID-19
Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for COVID-19 Open
COVID-19 in immunocompromised patients is difficult to treat. SARS-CoV-2 interaction with the host immune system and the role of therapy still remains only partly understood. There are no data regarding the use of monoclonal antibodies and…
View article: Short Course of Antifungal Therapy in Patients With Uncomplicated <i>Candida</i> Bloodstream Infection: Another Case of Less Is More in the Clinical Setting?
Short Course of Antifungal Therapy in Patients With Uncomplicated <i>Candida</i> Bloodstream Infection: Another Case of Less Is More in the Clinical Setting? Open
Background The objective of this study was to compare the clinical outcomes of patients receiving a short course (SC) vs a prolonged course (PC) of antifungal therapy for uncomplicated Candida bloodstream infections (BSIs). Methods All epi…
View article: High–temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines
High–temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines Open
Knowledge of the mechanisms underpinning the development of protective immunity conferred by mRNA vaccines is fragmentary. Here, we investigated responses to coronavirus disease 2019 (COVID-19) mRNA vaccination via high–temporal resolution…
View article: High temporal resolution systems profiling reveals distinct patterns of interferon response after Covid-19 mRNA vaccination and SARS-CoV2 infection
High temporal resolution systems profiling reveals distinct patterns of interferon response after Covid-19 mRNA vaccination and SARS-CoV2 infection Open
Knowledge of the mechanisms underpinning the development of protective immunity conferred by mRNA vaccines is fragmentary. Here we investigated responses to COVID-19 mRNA vaccination via ultra-low-volume sampling and high-temporal-resoluti…
View article: Enterococcal bloodstream infections in critically ill patients with COVID-19: a case series
Enterococcal bloodstream infections in critically ill patients with COVID-19: a case series Open
The cumulative incidence of enterococcal BSI is high in critically ill patients with COVID-19. Our results suggest a crucial role of the severity of the acute clinical conditions, to which both the underlying viral pneumonia and the entero…
View article: Kidney disease and all-cause mortality in patients with COVID-19 hospitalized in Genoa, Northern Italy
Kidney disease and all-cause mortality in patients with COVID-19 hospitalized in Genoa, Northern Italy Open
Background The prevalence of kidney involvement during SARS-CoV-2 infection has been reported to be high. Nevertheless, data are lacking about the determinants of acute kidney injury (AKI) and the combined effect of chronic kidney disease …
View article: Tocilizumab and steroid treatment in patients with COVID-19 pneumonia
Tocilizumab and steroid treatment in patients with COVID-19 pneumonia Open
Early adjunctive treatment with tocilizumab, methylprednisolone or both may improve outcomes in non-intubated patients with COVID-19 pneumonia.
View article: Clinical characteristics, management and in-hospital mortality of patients with coronavirus disease 2019 in Genoa, Italy
Clinical characteristics, management and in-hospital mortality of patients with coronavirus disease 2019 in Genoa, Italy Open
View article: Tocilizumab and steroid treatment in patients with COVID-19 pneumonia
Tocilizumab and steroid treatment in patients with COVID-19 pneumonia Open
Introduction Coronavirus disease 2019 (COVID-19) can lead to respiratory failure due to severe immune response. Treatment targeting this immune response might be beneficial but there is limited evidence on its efficacy. The aim of this stu…