Explanipedia

Disability Worsening Phenotypes in Multiple Sclerosis and Impact of Disease-Modifying Treatments Open

Raffaello Bonacchi, M. Betti, Matteo Foschi, Diana Ferraro, Pietro Annovazzi , et al. · 2025

We identified 4 clinically relevant disability worsening phenotypes in relapse-onset MS, primarily driven by PIRA, with greater CNS involvement linked to early and rapid progression. Despite reliance on EDSS alone, these phenotypes may inf…

Recent Advances in Androgen Receptor Pathway Inhibitors for Castration-Sensitive Prostate Cancer Open

Andrea Lancia, Marco Oderda, Federico Camilli, Eleonora Festa, Marta Bottero , et al. · 2025

Prostate cancer (PCa) is the second most common cancer in men, and it is frequently diagnosed at an advanced stage of the disease. Androgen Deprivation Therapy (ADT) has traditionally represented the backbone of therapy for high-risk, recu…

The cascade sign in aquaporin-4-IgG positive (AQP4-IgG+) NMOSD Open

Luigi Bonan, Federico Camilli, Marco Bombardi, Chiara Leoni, Francesca Rondelli , et al. · 2025

Background: The cascade sign was reported in 2003 as pathognomonic of the parenchymal form of neuro-Behçet’s. At the time, diencephalo-mesencephalic lesions in neuromyelitis optica (NMO) were largely ignored. Only with the 2015 revision of…

Hypogammaglobulinemia and severe infections in Multiple Sclerosis patients on anti-CD20 agents: A multicentre study Open

Krzysztof Smolik, Federico Camilli, Ivan Panzera, Alessia Fiore, Alessio Franceschini , et al. · 2024

IgG and IgM HG occurred in a considerable proportion of patients. IgG HG increased the risk of SI, which were, nevertheless, relatively infrequent. Our results highlight the importance of monitoring immunoglobulin levels during treatment w…

Biology-guided radiotherapy in metastatic prostate cancer: time to push the envelope? Open

Andrea Lancia, Gianluca Ingrosso, Beatrice Detti, Eleonora Festa, Elisabetta Bonzano , et al. · 2024

The therapeutic landscape of metastatic prostate cancer has undergone a profound revolution in recent years. In addition to the introduction of novel molecules in the clinics, the field has witnessed a tremendous development of functional …

A systematic review and meta-analysis of intraoperative electron radiation therapy delivered with a dedicated mobile linac for partial breast irradiation in early breast cancer Open

Cynthia Aristei, Federico Camilli, Valeria Epifani, Simona Borghesi, Isabella Palumbo , et al. · 2024

Dissipation of Motor Sleep Inertia and Motor Wake Inertia in Early Relapsing–Remitting Multiple Sclerosis Open

Lorenzo Tonetti, Federico Camilli, Sara Giovagnoli, Alessandra Lugaresi, Vincenzo Natale · 2023

While previous studies have described the time course of the dissipation of motor sleep inertia (around 70 min after wake-up time) and motor wake inertia (around 20 min after bedtime) in healthy controls (HCs), the corresponding knowledge …

External validation of three prognostic scores for brain metastasis velocity in patients treated with intracranial stereotactic radiotherapy Open

Sebastian M. Christ, Kim Borsky, Johannes Kraft, Simon Frei, Jonas Willmann , et al. · 2023

This study externally validated cBMV and iBMV as prognostic scores for OS in patients treated with SRT for BMs whereas validation of vBMV was not achieved.

Difference in safety and humoral response to mRNA SARS-CoV-2 vaccines in patients with autoimmune neurological disorders: the ANCOVAX study Open

Maria Pia Giannoccaro, Veria Vacchiano, Marta Leone, Federico Camilli, Corrado Zenesini , et al. · 2022

COVID-19 Severity in Multiple Sclerosis Open

Maria Pia Sormani, Irene Schiavetti, Luca Carmisciano, Cinzia Cordioli, Massimo Filippi , et al. · 2021

Background and objectives: It is unclear how multiple sclerosis (MS) affects the severity of COVID-19. The aim of this study is to compare COVID-19-related outcomes collected in an Italian cohort of patients with MS with the outcomes expec…

Inflammatory optic neuropathy following SARS-CoV-2 mRNA vaccine: Description of two cases Open

Valentina Barone, Federico Camilli, Michela Crisci, Cinzia Scandellari, Piero Barboni , et al. · 2021

SARS-CoV-2 serology after COVID-19 in multiple sclerosis: An international cohort study Open

Maria Pia Sormani, Irene Schiavetti, Doriana Landi, Luca Carmisciano, Nicola De Rossi , et al. · 2021

Background: The MuSC-19 project is an Italian cohort study open to international partners that collects data on multiple sclerosis (MS) patients with COVID-19. During the second wave of the pandemic, serological tests became routinely avai…

A Pilot Study of 24-h Motor Activity Patterns in Multiple Sclerosis: Pre-Planned Follow-Up at 2 Years Open

Lorenzo Tonetti, Federico Camilli, Sara Giovagnoli, Vincenzo Natale, Alessandra Lugaresi · 2021

Early multiple sclerosis (MS) predictive markers of disease activity/prognosis have been proposed but are not universally accepted. Aim of this pilot prospective study is to verify whether a peculiar hyperactivity, observed at baseline (T0…

Circadian Activity Rhythm in Early Relapsing–Remitting Multiple Sclerosis Open

Lorenzo Tonetti, Federico Camilli, Sara Giovagnoli, Vincenzo Natale, Alessandra Lugaresi · 2019

While relapsing–remitting is the most prevalent course of multiple sclerosis, the prognostic/predictive markers of the worsening of symptomatology are still debated. With reference to other diseases, the study of the circadian activity rhy…

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