Federico Perdomo-Celis
YOU?
Author Swipe
View article: Impact of rosuvastatin on the memory potential and functionality of CD8+ T cells from people with HIV
Impact of rosuvastatin on the memory potential and functionality of CD8+ T cells from people with HIV Open
View article: A low pre-existing anti-NS1 humoral immunity to DENV is associated with microcephaly development after gestational ZIKV exposure
A low pre-existing anti-NS1 humoral immunity to DENV is associated with microcephaly development after gestational ZIKV exposure Open
Background Gestational Zika virus (ZIKV) infection is associated with the development of congenital Zika syndrome (CZS), which includes microcephaly and fetal demise. The magnitude and quality of orthoflavivirus-specific humoral immunity h…
View article: Benefits of INSTI‐Based Regimens in a Real‐World Setting of People Living With HIV‐1 in Colombia
Benefits of INSTI‐Based Regimens in a Real‐World Setting of People Living With HIV‐1 in Colombia Open
Objective: The objective is to compare the clinical, virological, and immunological characteristics of people living with HIV‐1 who were treated with first‐line integrase inhibitors (INSTIs) versus those treated with other antiretrovirals.…
View article: Sustained HIV remission after allogeneic hematopoietic stem cell transplantation with wild-type CCR5 donor cells
Sustained HIV remission after allogeneic hematopoietic stem cell transplantation with wild-type CCR5 donor cells Open
View article: Evaluation of Four Humanized NOD-Derived Mouse Models for Dengue Virus-2 Infection
Evaluation of Four Humanized NOD-Derived Mouse Models for Dengue Virus-2 Infection Open
Dengue is a significant public health problem with no specific viral treatment. One of the main challenges in studying dengue is the lack of adequate animal models recapitulating human immune responses. Most studies on humanized mice use N…
View article: Dynamics of virological and immunological markers of HIV persistence after allogeneic haematopoietic stem-cell transplantation in the IciStem cohort: a prospective observational cohort study
Dynamics of virological and immunological markers of HIV persistence after allogeneic haematopoietic stem-cell transplantation in the IciStem cohort: a prospective observational cohort study Open
View article: Update on Early-Life T Cells: Impact on Oral Rotavirus Vaccines
Update on Early-Life T Cells: Impact on Oral Rotavirus Vaccines Open
Rotavirus infection continues to be a significant public health problem in developing countries, despite the availability of several vaccines. The efficacy of oral rotavirus vaccines in young children may be affected by significant immunol…
View article: A low pre-existing anti-NS1 humoral immunity to DENV is associated with microcephaly development after gestational ZIKV exposure
A low pre-existing anti-NS1 humoral immunity to DENV is associated with microcephaly development after gestational ZIKV exposure Open
Background Gestational Zika virus (ZIKV) infection is associated with the development of congenital Zika syndrome (CZS), which includes microcephaly and fetal demise. The magnitude and quality of orthoflavivirus-specific humoral immunity h…
View article: Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8+ T-cells
Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8+ T-cells Open
View article: Corrigendum: Cross-reactive humoral and CD4+ T cell responses to Mu and Gamma SARS-CoV-2 variants in a Colombian population
Corrigendum: Cross-reactive humoral and CD4+ T cell responses to Mu and Gamma SARS-CoV-2 variants in a Colombian population Open
[This corrects the article DOI: 10.3389/fimmu.2023.1241038.].
View article: Cross-reactive humoral and CD4+ T cell responses to Mu and Gamma SARS-CoV-2 variants in a Colombian population
Cross-reactive humoral and CD4+ T cell responses to Mu and Gamma SARS-CoV-2 variants in a Colombian population Open
The SARS CoV-2 antibody and CD4 + T cell responses induced by natural infection and/or vaccination decline over time and cross-recognize other viral variants at different levels. However, there are few studies evaluating the levels and dur…
View article: A Comparison of Lymphoid and Myeloid Cells Derived from Human Hematopoietic Stem Cells Xenografted into NOD-Derived Mouse Strains
A Comparison of Lymphoid and Myeloid Cells Derived from Human Hematopoietic Stem Cells Xenografted into NOD-Derived Mouse Strains Open
Humanized mice are an invaluable tool for investigating human diseases such as cancer, infectious diseases, and graft-versus-host disease (GvHD). However, it is crucial to understand the strengths and limitations of humanized mice and sele…
View article: Recent advances in CD8+ T cell-based immune therapies for HIV cure
Recent advances in CD8+ T cell-based immune therapies for HIV cure Open
Achieving a cure for HIV infection is a global priority. There is substantial evidence supporting a central role for CD8+ T cells in the natural control of HIV, suggesting the rationale that these cells may be exploited to achie…
View article: Early antiretroviral therapy favors post-treatment SIV control associated with expansion of enhanced memory CD8+ T cells. pVISCONTI study
Early antiretroviral therapy favors post-treatment SIV control associated with expansion of enhanced memory CD8+ T cells. pVISCONTI study Open
Post-treatment HIV controllers (PTCs) offer evidence that HIV remission can be achieved in some people after antiretroviral treatment (ART) discontinuation. However, the circumstances and mechanisms leading to PTC remain unclear. We evalua…
View article: Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection
Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection Open
View article: In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation
In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation Open
View article: Reprogramming dysfunctional CD8+ T cells to promote properties associated with natural HIV control
Reprogramming dysfunctional CD8+ T cells to promote properties associated with natural HIV control Open
In Figure 1E, the data for BCL-6 was inadvertently omitted, with a duplicate of the data for TOX shown on that line instead.
View article: Identification of CD8+ T cell subsets that normalize in early-treated people living with HIV receiving antiretroviral therapy
Identification of CD8+ T cell subsets that normalize in early-treated people living with HIV receiving antiretroviral therapy Open
View article: Limits of detection of antibody pairs to detect DENV Serotype.
Limits of detection of antibody pairs to detect DENV Serotype. Open
The limits of detection (LoD) and dissociation constant (Kd) were calculated for each antibody pair for the detection of its respective dengue serotype using ELISA (a) and dipstick (b) formats. (DOCX)
View article: Serotype-specific detection of dengue viruses in a nonstructural protein 1-based enzyme-linked immunosorbent assay validated with a multi-national cohort
Serotype-specific detection of dengue viruses in a nonstructural protein 1-based enzyme-linked immunosorbent assay validated with a multi-national cohort Open
Our study demonstrates a robust antibody screening strategy that enabled the development of a serotype NS1-based ELISA with maximized specific and sensitive antigen binding. This sensitive and specific assay also utilized the most expansiv…
View article: High activation and skewed T cell differentiation are associated with low IL-17A levels in a hu-PBL-NSG-SGM3 mouse model of HIV infection
High activation and skewed T cell differentiation are associated with low IL-17A levels in a hu-PBL-NSG-SGM3 mouse model of HIV infection Open
Summary The humanized NOD/SCID/IL-2 receptor γ-chainnull (NSG) mouse model has been widely used for the study of HIV pathogenesis. Here, NSG mice with transgenic expression of human stem cell factor (SCF), granulocyte–macrophage colony-sti…
View article: Characterization of CXCR5+ CD8+ T-cells in humanized NSG mice
Characterization of CXCR5+ CD8+ T-cells in humanized NSG mice Open
Humanized NOD/SCID/IL-2 receptor γ-chainnull (huNSG) mice recapitulate some features of human T-cell populations that can be exploited in basic and pre-clinical research. CXCR5+ T CD8+ T-cells play an impor…
View article: CD8+ T-Cell Response to HIV Infection in the Era of Antiretroviral Therapy
CD8+ T-Cell Response to HIV Infection in the Era of Antiretroviral Therapy Open
Although the combined antiretroviral therapy (cART) has decreased the deaths associated with the immune deficiency acquired syndrome (AIDS), non-AIDS conditions have emerged as an important cause of morbidity and mortality in HIV-infected …
View article: HIV Replication in Humanized IL-3/GM-CSF-Transgenic NOG Mice
HIV Replication in Humanized IL-3/GM-CSF-Transgenic NOG Mice Open
The development of mouse models that mimic the kinetics of Human Immunodeficiency Virus (HIV) infection is critical for the understanding of the pathogenesis of disease and for the design of novel therapeutic strategies. Here, we describe …
View article: T-Cell Response to Viral Hemorrhagic Fevers
T-Cell Response to Viral Hemorrhagic Fevers Open
Viral hemorrhagic fevers (VHF) are a group of clinically similar diseases that can be caused by enveloped RNA viruses primarily from the families Arenaviridae, Filoviridae, Hantaviridae, and Flaviviridae. Clinically, this group of diseases…
View article: An altered cytotoxic program of CD8+ T-cells in HIV-infected patients despite HAART-induced viral suppression
An altered cytotoxic program of CD8+ T-cells in HIV-infected patients despite HAART-induced viral suppression Open
Despite the suppression of viral replication induced by the highly active anti-retroviral therapy (HAART), an increased immune activation and inflammatory state persists in HIV-infected patients, contributing to lower treatment response an…
View article: A Low Frequency of IL-17-Producing CD8+ T-Cells Is Associated With Persistent Immune Activation in People Living With HIV Despite HAART-Induced Viral Suppression
A Low Frequency of IL-17-Producing CD8+ T-Cells Is Associated With Persistent Immune Activation in People Living With HIV Despite HAART-Induced Viral Suppression Open
Immune activation is the hallmark of HIV infection, even in patients with highly active anti-retroviral therapy (HAART)-induced viral suppression. A major cause of immune activation during HIV infection is the intestinal microbial transloc…
View article: Identification and Characterization at the Single-Cell Level of Cytokine-Producing Circulating Cells in Children With Dengue
Identification and Characterization at the Single-Cell Level of Cytokine-Producing Circulating Cells in Children With Dengue Open
In this study, we identified, at the single-cell level, naturally induced cytokine-producing circulating cells (CPCCs) in children with dengue virus (DENV) infection ranging clinically from mild to severe disease. Tumor necrosis factor alp…
View article: Follicular CD8+ T Cells: Origin, Function and Importance during HIV Infection
Follicular CD8+ T Cells: Origin, Function and Importance during HIV Infection Open
The lymphoid follicle is critical for the development of humoral immune responses. Cell circulation to this site is highly regulated by the differential expression of chemokine receptors. This feature contributes to the establishment of vi…
View article: Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum
Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum Open
A low-cost, equipment-free rapid antigen test distinguishes dengue virus serotypes and Zika virus in patient sera without detectable cross-reactivity.