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View article: Thoracic Spinal Sclerosing Epithelioid Fibrosarcoma Mimicking Schwannoma: Case Report and Literature Review
Thoracic Spinal Sclerosing Epithelioid Fibrosarcoma Mimicking Schwannoma: Case Report and Literature Review Open
Background/Objectives: Sclerosing epithelioid fibrosarcoma (SEF) is a rare soft tissue sarcoma with high rates of local recurrence and distant metastasis. Primary spinal involvement is exceedingly uncommon and often misdiagnosed due to rad…
View article: P03.08.A A PILOT EXPERIENCE OF APPLICATION OF RANO 2D AND 3D IN PATIENTS WITH NEWLY-DIAGNOSED ASTROCYTOMA IDH MUTANT CNS WHO GRADE 4
P03.08.A A PILOT EXPERIENCE OF APPLICATION OF RANO 2D AND 3D IN PATIENTS WITH NEWLY-DIAGNOSED ASTROCYTOMA IDH MUTANT CNS WHO GRADE 4 Open
BACKGROUND The WHO 2021 classification of central nervous system (CNS) tumors introduced astrocytoma IDH mutant WHO grade 4 (AG4) as a novel and distinct entity with better outcome compared to glioblastoma IDH wild type (GBM). Volumetric a…
View article: Cervical vertebral metastases from a recurrent intracranial anaplastic meningioma: illustrative case
Cervical vertebral metastases from a recurrent intracranial anaplastic meningioma: illustrative case Open
BACKGROUND Meningiomas represent the most prevalent primary tumors of the central nervous system, with the majority classified as benign (WHO grade I) and exhibiting favorable prognoses. However, a rare subset of meningiomas show malignant…
View article: Circumferential lumbar arthrodesis and decompression for degenerative disorders: robot- assisted exoscope with head-mounted display versus traditional microscope
Circumferential lumbar arthrodesis and decompression for degenerative disorders: robot- assisted exoscope with head-mounted display versus traditional microscope Open
Introduction Lumbar degenerative diseases, including lumbar spinal stenosis, spondylolisthesis, and degenerative disc disease, are a growing concern in aging populations. Circumferential lumbar arthrodesis and decompression are effective s…
View article: Exploring the Role of ADCs in Brain Metastases and Primary Brain Tumors: Insight and Future Directions
Exploring the Role of ADCs in Brain Metastases and Primary Brain Tumors: Insight and Future Directions Open
Primary and secondary brain tumors have always been a challenge due to their high morbidity and poor prognosis. The incidence of brain metastasis is also increasing with the advent of effective new treatments. Traditional systemic treatmen…
View article: Upper Limb Neural Tension Test and Spinal Biomechanics: Insights from a Longitudinal Pilot Study
Upper Limb Neural Tension Test and Spinal Biomechanics: Insights from a Longitudinal Pilot Study Open
Background: The Upper Limb Neural Tension Test (ULNTT) is a common assessment for neurodynamic function, yet the relationship between ULNTT findings and specific spinal biomechanical patterns remains poorly understood, particularly in the …
View article: The Fleece of Stilling: History of cerebellar white matter
The Fleece of Stilling: History of cerebellar white matter Open
Introduction The cerebellum harbours different functions, ranging from motor to cognitive and linguistic skills. This complex functional landscape is founded on a specific architecture of intracerebellar white matter fibres surrounding the…
View article: Neurological Outcome of Spinal Hemangioblastomas: An International Observational Multicenter Study About 35 Surgical Cases
Neurological Outcome of Spinal Hemangioblastomas: An International Observational Multicenter Study About 35 Surgical Cases Open
Introduction: Hemangioblastomas (HBs) are benign, highly vascular tumors that can be found intracranially or in the spinal region, representing around 2–15% of primary intramedullary tumors. They can occur sporadically or in association wi…
View article: Proliferation-Diffusion Modeling in Glioblastoma: Impact of Supramaximal Resection on Survival
Proliferation-Diffusion Modeling in Glioblastoma: Impact of Supramaximal Resection on Survival Open
Purpose: To evaluate the role of tumor invasiveness profile in a homogeneous cohort of patients with newly diagnosed GBM (2021 WHO) that underwent SUPR by the RANO criteria, and to analyze its impact on survival outcomes. Methods: Patients…
View article: Hybrid Therapy with SBRT Target-Tailored Tumor Resection for High-Grade Metastatic Epidural Spinal Cord Compression (MESCC): Illustrative Case
Hybrid Therapy with SBRT Target-Tailored Tumor Resection for High-Grade Metastatic Epidural Spinal Cord Compression (MESCC): Illustrative Case Open
Background: Spinal metastases affect approximately 40% of patients with systemic cancers; metastatic epidural spinal cord compression (MESCC) occurs in up to 20% of cases and leads to potential significant morbidity. Recent advancements in…
View article: Lumbopelvic Fixation: How to Be Less Invasive When You Cannot Be Minimally Invasive—A New Subcutaneous Supra-Fascial Approach to Minimize Open Iliac Screwing
Lumbopelvic Fixation: How to Be Less Invasive When You Cannot Be Minimally Invasive—A New Subcutaneous Supra-Fascial Approach to Minimize Open Iliac Screwing Open
Background/Objectives: Lumbopelvic fixation (LPF) is essential for stabilizing the lumbosacral junction (LSJ) in cases of trauma, tumors, and other pathologies. While minimally invasive percutaneous techniques are preferred when feasible, …
View article: In Reply to the Letter to the Editor Regarding: "Predictive Factors of Long-Term Neurologic Outcome and Progression-Free Survival in Intramedullary Spinal Cord Tumors: A 10-Year Single-Center Cohort Study and Review of the Literature"
In Reply to the Letter to the Editor Regarding: "Predictive Factors of Long-Term Neurologic Outcome and Progression-Free Survival in Intramedullary Spinal Cord Tumors: A 10-Year Single-Center Cohort Study and Review of the Literature" Open
View article: Extracellular vesicles released by glioblastoma cancer cells drive tumor invasiveness via Connexin-43 gap junctions
Extracellular vesicles released by glioblastoma cancer cells drive tumor invasiveness via Connexin-43 gap junctions Open
Background Although invasiveness is one of the major determinants of the poor glioblastoma (GBM) outcome, the mechanisms of GBM invasion are only partially understood. Among the intrinsic and environmental processes promoting cell-to-cell …
View article: THE DENTATE NUCLEUS AND THE FLEECE OF STILLING: NARRATIVE REVIEW ON THE HISTORY OF INTRACEREBELLAR WHITE MATTER ANATOMY
THE DENTATE NUCLEUS AND THE FLEECE OF STILLING: NARRATIVE REVIEW ON THE HISTORY OF INTRACEREBELLAR WHITE MATTER ANATOMY Open
Introduction: The cerebellum harbors a variety of different functions, ranging from motor to cognitive and linguistic skills. This complex functional landscape is founded on an intricate and specific architecture of intracerebellar white m…
View article: Persistent primitive trigeminal artery in stroke: A review and clinical insights
Persistent primitive trigeminal artery in stroke: A review and clinical insights Open
The persistent primitive trigeminal artery is the most common remnant of the embryonic carotid-basilar connection. While its anatomy is well documented, its clinical significance in strokes remains debated. Some studies suggest it predispo…
View article: SURGERY AND NEUROLOGICAL OUTCOMES FOR SPINAL HEMANGIOBLASTOMAS: AN INTERNATIONAL MULTICENTER RETROSPECTIVE STUDY OF 35 CASES
SURGERY AND NEUROLOGICAL OUTCOMES FOR SPINAL HEMANGIOBLASTOMAS: AN INTERNATIONAL MULTICENTER RETROSPECTIVE STUDY OF 35 CASES Open
View article: Gamma Knife Radiosurgery for Tumor-related Trigeminal Neuralgia: a Single-center Retrospective Study
Gamma Knife Radiosurgery for Tumor-related Trigeminal Neuralgia: a Single-center Retrospective Study Open
View article: Comparative analysis of mini-open trans-thoracic transpleural and posterior approaches in thoracic disc herniation surgery: A 10-year retrospective review
Comparative analysis of mini-open trans-thoracic transpleural and posterior approaches in thoracic disc herniation surgery: A 10-year retrospective review Open
Both approaches effectively alleviate symptoms in symptomatic TDHs. The anterior approach offers greater neurological improvement but carries higher complication risks. Surgical strategy should be tailored based on herniation characteristi…
View article: The Impact of Intraoperative CT-Based Navigation in Congenital Craniovertebral Junction Anomalies: New Concepts of Treatment
The Impact of Intraoperative CT-Based Navigation in Congenital Craniovertebral Junction Anomalies: New Concepts of Treatment Open
Background: Congenital craniovertebral junction anomalies (CCVJAs) encompass a diverse range of conditions characterized by distorted anatomy and significant variation in the pathways of neurovascular structures. This study aims to assess …
View article: Microvascular decompression in trigeminal neuralgia using a robot-assisted exoscope and head-mounted display
Microvascular decompression in trigeminal neuralgia using a robot-assisted exoscope and head-mounted display Open
OBJECTIVE Microvascular decompression (MVD) in trigeminal neuralgia (TN) is currently managed using an operating microscope (OM). Recent experiences with endoscopy-assisted, fully endoscopic, and exoscopic surgery have been described, aimi…
View article: Glioblastoma invasion patterns from a clinical perspective—a systematic review
Glioblastoma invasion patterns from a clinical perspective—a systematic review Open
View article: Surgical management of congenital cervical spondylolytic spondylolisthesis: illustrative case
Surgical management of congenital cervical spondylolytic spondylolisthesis: illustrative case Open
BACKGROUND Congenital cervical spondylolytic spondylolisthesis is a rare and complex disorder of the cervical spine. Surgical treatment is reserved for those symptomatic patients who do not improve with conservative management. OBSERVATION…
View article: Gliomagenesis, Epileptogenesis, and Remodeling of Neural Circuits: Relevance for Novel Treatment Strategies in Low- and High-Grade Gliomas
Gliomagenesis, Epileptogenesis, and Remodeling of Neural Circuits: Relevance for Novel Treatment Strategies in Low- and High-Grade Gliomas Open
Gliomas present a complex challenge in neuro-oncology, often accompanied by the debilitating complication of epilepsy. Understanding the biological interaction and common pathways between gliomagenesis and epileptogenesis is crucial for im…
View article: Aggressive giant dumbell-shaped thoracic vertebral hemangioma: illustrative case
Aggressive giant dumbell-shaped thoracic vertebral hemangioma: illustrative case Open
BACKGROUND Vertebral hemangioma is the most common benign tumor of the spine, diagnosed incidentally in most cases. In 0.4% of patients, the lesion is considered aggressive, causing neurological deficits. This subtype of hemangioma is char…
View article: From data to practice: brain meningioma treatment in elderly patients – a survey of the Italian Society of Neurosurgery (SINch®) and systematic review and meta-analysis
From data to practice: brain meningioma treatment in elderly patients – a survey of the Italian Society of Neurosurgery (SINch®) and systematic review and meta-analysis Open
View article: Dissecting the prognostic signature of patients with astrocytoma isocitrate dehydrogenase-mutant grade 4: a large multicenter, retrospective study
Dissecting the prognostic signature of patients with astrocytoma isocitrate dehydrogenase-mutant grade 4: a large multicenter, retrospective study Open
This is the largest experience in Western countries exploring the prognostic signature of patients with A IDHm CNS G4. Our results show that MGMT promoter methylation and TERT promoter mutation may impact clinical outcomes. This may suppor…
View article: The role of preoperative [11C]methionine PET in defining tumor-related epilepsy and predicting short-term postoperative seizure control in temporal lobe low-grade gliomas
The role of preoperative [11C]methionine PET in defining tumor-related epilepsy and predicting short-term postoperative seizure control in temporal lobe low-grade gliomas Open
OBJECTIVE Surgery is the mainstay of treatment for low-grade glioma (LGG)–related epilepsy. However, the goal of achieving both oncological radical resection and seizure freedom can be challenging. PET with [ 11 C]methionine (MET) has been…
View article: T Cell Features in Glioblastoma May Guide Therapeutic Strategies to Overcome Microenvironment Immunosuppression
T Cell Features in Glioblastoma May Guide Therapeutic Strategies to Overcome Microenvironment Immunosuppression Open
Glioblastoma (GBM) is the most aggressive and lethal primary brain tumor, bearing a survival estimate below 10% at five years, despite standard chemoradiation treatment. At recurrence, systemic treatment options are limited and the standar…
View article: Dataset related to article "The prognostic power of [11C]methionine PET in IDH-wildtype diffuse gliomas with lower-grade histological features: venturing beyond WHO classification"
Dataset related to article "The prognostic power of [11C]methionine PET in IDH-wildtype diffuse gliomas with lower-grade histological features: venturing beyond WHO classification" Open
<p>This record contains raw data related to article “The prognostic power of [<sup>11</sup>C]methionine PET in IDH-wildtype diffuse gliomas with lower-grade histological features: venturing beyond WHO classification…
View article: Multimodal Intraoperative Neurophysiological Monitoring in Intramedullary Spinal Cord Tumors: A 10-Year Single Center Experience
Multimodal Intraoperative Neurophysiological Monitoring in Intramedullary Spinal Cord Tumors: A 10-Year Single Center Experience Open
Objective: The study aimed at evaluating the efficacy and the ability of D-wave monitoring combined with somatosensory evoked potentials (SSEPs) and motor evoked potentials (MEPs) to predict functional outcomes in intramedullary spinal cor…