Fedor Šimko
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View article: Melatonin stabilizes atherosclerotic plaques: an association that should be clinically exploited
Melatonin stabilizes atherosclerotic plaques: an association that should be clinically exploited Open
Atherosclerosis is the underlying factor in the premature death of millions of humans annually. The cause of death is often a result of the rupture of an atherosclerotic plaque followed by the discharge of the associated molecular debris i…
View article: Considering chronotype to improve hypertension management
Considering chronotype to improve hypertension management Open
View article: Pharmacological stimulation of the parasympathetic system – a promising means of cardioprotection in heart failure
Pharmacological stimulation of the parasympathetic system – a promising means of cardioprotection in heart failure Open
View article: Sacubitril/Valsartan Alleviates Cardiac Remodeling and Dysfunction in L-NAME-Induced Hypertension and Hypertensive Heart Disease
Sacubitril/Valsartan Alleviates Cardiac Remodeling and Dysfunction in L-NAME-Induced Hypertension and Hypertensive Heart Disease Open
There is ample evidence on the benefit of angiotensin receptor-neprilysin inhibitors (ARNIs) in heart failure, yet data regarding the potential protective action of ARNIs in hypertensive heart disease are sparse. The aim of this study was …
View article: Effect of sacubitril/valsartan on the hypertensive heart in continuous light-induced and lactacystin-induced pre-hypertension: Interactions with the renin-angiotensin-aldosterone system
Effect of sacubitril/valsartan on the hypertensive heart in continuous light-induced and lactacystin-induced pre-hypertension: Interactions with the renin-angiotensin-aldosterone system Open
This study investigated whether sacubitril/valsartan or valsartan are able to prevent left ventricular (LV) fibrotic remodelling and dysfunction in two experimental models of pre-hypertension induced by continuous light (24 hours/day) expo…
View article: Mitochondrial Melatonin: Beneficial Effects in Protecting against Heart Failure
Mitochondrial Melatonin: Beneficial Effects in Protecting against Heart Failure Open
Cardiovascular disease is the cause of physical infirmity and thousands of deaths annually. Typically, during heart failure, cardiomyocyte mitochondria falter in terms of energy production and metabolic processing. Additionally, inflammati…
View article: The effect of zofenopril on the cardiovascular system of spontaneously hypertensive rats treated with the ACE2 inhibitor MLN-4760
The effect of zofenopril on the cardiovascular system of spontaneously hypertensive rats treated with the ACE2 inhibitor MLN-4760 Open
View article: Ivabradine curbs isoproterenol-induced kidney fibrosis
Ivabradine curbs isoproterenol-induced kidney fibrosis Open
This study investigated whether chronic isoproterenol administration could induce kidney alterations and whether ivabradine, a heart rate (HR)-reducing substance exerting cardiovascular protection, is able to attenuate potential kidney dam…
View article: Melatonin as a Potential Approach to Anxiety Treatment
Melatonin as a Potential Approach to Anxiety Treatment Open
Anxiety disorders are the most common mental diseases. Anxiety and the associated physical symptoms may disturb social and occupational life and increase the risk of somatic diseases. The pathophysiology of anxiety development is complex a…
View article: Lactacystin-induced kidney fibrosis: Protection by melatonin and captopril
Lactacystin-induced kidney fibrosis: Protection by melatonin and captopril Open
Lactacystin is a specific proteasome inhibitor that blocks the hydrolysis of intracellular proteins by ubiquitin/proteasome system inhibition. The administration of lactacystin to rats induced hypertension and remodeling of the left ventri…
View article: Sacubitril/Valsartan and Ivabradine Attenuate Left Ventricular Remodelling and Dysfunction in Spontaneously Hypertensive Rats: Different Interactions with the Renin–Angiotensin–Aldosterone System
Sacubitril/Valsartan and Ivabradine Attenuate Left Ventricular Remodelling and Dysfunction in Spontaneously Hypertensive Rats: Different Interactions with the Renin–Angiotensin–Aldosterone System Open
This study investigated whether sacubitril/valsartan and ivabradine are able to prevent left ventricular (LV) fibrotic remodelling and dysfunction in a rat experimental model of spontaneous hypertension (spontaneously hypertensive rats, SH…
View article: Early Treatment of Acute Myocardial Infarction with Melatonin: Effects on MMP-9 and Adverse Cardiac Events
Early Treatment of Acute Myocardial Infarction with Melatonin: Effects on MMP-9 and Adverse Cardiac Events Open
Background: Matrix metalloproteinase-9 (MMP-9) is crucial in tissue remodeling after an adverse cardiac event. In experimental studies, melatonin has been found to attenuate MMP-9 activation. The present study assessed the effects of syste…
View article: Melatonin use for SARS‐CoV‐2 infection: Time to diversify the treatment portfolio
Melatonin use for SARS‐CoV‐2 infection: Time to diversify the treatment portfolio Open
We were pleased to read the publication by Lan and colleagues [1] which included a meta-analysis of the Randomized Controlled Trials (RTCs) in which melatonin was used as a treatment for COVID-19.This article is protected by copyright. All…
View article: Melatonin: highlighting its use as a potential treatment for SARS-CoV-2 infection
Melatonin: highlighting its use as a potential treatment for SARS-CoV-2 infection Open
View article: Commentary: Effect of Angiotensin-Converting-Enzyme Inhibitor and Angiotensin II Receptor Antagonist Treatment on ACE2 Expression and SARS-CoV-2 Replication in Primary Airway Epithelial Cells
Commentary: Effect of Angiotensin-Converting-Enzyme Inhibitor and Angiotensin II Receptor Antagonist Treatment on ACE2 Expression and SARS-CoV-2 Replication in Primary Airway Epithelial Cells Open
GENERAL COMMENTARY article Front. Pharmacol., 28 January 2022Sec. Translational Pharmacology Volume 13 - 2022 | https://doi.org/10.3389/fphar.2022.842512
View article: Cardiovascular therapeutics: A new potential for anxiety treatment?
Cardiovascular therapeutics: A new potential for anxiety treatment? Open
Besides the well‐recognized risk factors, novel conditions increasing cardiovascular morbidity and mortality are emerging. Undesirable emotions and behavior such as anxiety and depression, appear to participate in worsening cardiovascular …
View article: Chronotherapy of cardiovascular pathologies: a hopeful strategy
Chronotherapy of cardiovascular pathologies: a hopeful strategy Open
View article: Monitoring Non-dipping Heart Rate by Consumer-Grade Wrist-Worn Devices: An Avenue for Cardiovascular Risk Assessment in Hypertension
Monitoring Non-dipping Heart Rate by Consumer-Grade Wrist-Worn Devices: An Avenue for Cardiovascular Risk Assessment in Hypertension Open
OPINION article Front. Cardiovasc. Med., 23 July 2021 | https://doi.org/10.3389/fcvm.2021.711417
View article: Hypertension chronotherapy: does dosing antihypertensive medication at bedtime determine cardiovascular prognosis?
Hypertension chronotherapy: does dosing antihypertensive medication at bedtime determine cardiovascular prognosis? Open
tejto práci rovnakou mierou, a
View article: The Impact of microRNAs in Renin–Angiotensin-System-Induced Cardiac Remodelling
The Impact of microRNAs in Renin–Angiotensin-System-Induced Cardiac Remodelling Open
Current knowledge on the renin–angiotensin system (RAS) indicates its central role in the pathogenesis of cardiovascular remodelling via both hemodynamic alterations and direct growth and the proliferation effects of angiotensin II or aldo…
View article: Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat?
Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat? Open
Angiotensin-converting enzyme 2 (ACE2) is the leading player of the protective renin–angiotensin system (RAS) pathway but also the entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). RAS inhibitors seemed to in…
View article: Renin–Angiotensin–Aldosterone System: Friend or Foe—The Matter of Balance. Insight on History, Therapeutic Implications and COVID-19 Interactions
Renin–Angiotensin–Aldosterone System: Friend or Foe—The Matter of Balance. Insight on History, Therapeutic Implications and COVID-19 Interactions Open
The renin–angiotensin–aldosterone system (RAAS) ranks among the most challenging puzzles in cardiovascular medicine [...]
View article: Ivabradine and Blood Pressure Reduction: Underlying Pleiotropic Mechanisms and Clinical Implications
Ivabradine and Blood Pressure Reduction: Underlying Pleiotropic Mechanisms and Clinical Implications Open
OPINION article Front. Cardiovasc. Med., 10 February 2021 | https://doi.org/10.3389/fcvm.2021.607998
View article: Duálna inhibícia neprilyzínu a receptora typu 1 pre angiotenzín II vo svetle klinických štúdií / Dual inhibition of neprilysin and angiotensin II type 1 receptor in light of clinical studies
Duálna inhibícia neprilyzínu a receptora typu 1 pre angiotenzín II vo svetle klinických štúdií / Dual inhibition of neprilysin and angiotensin II type 1 receptor in light of clinical studies Open
Despite advances in heart failure (HF) pharmacotherapy over the last three decades, the residual mortality with HF remains high.The antipode to the drug-induced inhibition of vasoconstrictive and proliferative substances could be an increa…
View article: Renin–Angiotensin System: An Important Player in the Pathogenesis of Acute Respiratory Distress Syndrome
Renin–Angiotensin System: An Important Player in the Pathogenesis of Acute Respiratory Distress Syndrome Open
Acute respiratory distress syndrome (ARDS) is characterized by massive inflammation, increased vascular permeability and pulmonary edema. Mortality due to ARDS remains very high and even in the case of survival, acute lung injury can lead …
View article: Ivabradine improves survival and attenuates cardiac remodeling in isoproterenol‐induced myocardial injury
Ivabradine improves survival and attenuates cardiac remodeling in isoproterenol‐induced myocardial injury Open
This study investigated whether ivabradine, a selective I f current inhibitor reducing heart rate (HR), is able to improve survival and prevent left ventricular (LV) remodeling in isoproterenol‐induced heart damage. Wistar rats were treate…
View article: Melatonin as a putative protection against myocardial injury in COVID-19 infection
Melatonin as a putative protection against myocardial injury in COVID-19 infection Open
KEYWORDS: COVID-19SARS-CoV-2acute myocardial injurycytokine stormRASmelatoninantioxidantantiinflammation
View article: Ivabradine Ameliorates Kidney Fibrosis in L-NAME-Induced Hypertension
Ivabradine Ameliorates Kidney Fibrosis in L-NAME-Induced Hypertension Open
Hypertension-induced renal injury is characterized by structural kidney alterations and function deterioration. Therapeutics for kidney protection are limited, thus novel renoprotectives in hypertension are being continuously sought out. I…
View article: Is melatonin deficiency a unifying pathomechanism of high risk patients with COVID-19?
Is melatonin deficiency a unifying pathomechanism of high risk patients with COVID-19? Open
View article: Renin-angiotensin system and SARS-CoV-2 interaction: underlying mechanisms and potential clinical implications
Renin-angiotensin system and SARS-CoV-2 interaction: underlying mechanisms and potential clinical implications Open
Renin-angiotensin system (RAS) inhibition supposedly increases the expression of angiotensin converting enzyme 2, serving as a binding site for SARS-CoV-2. Concerns arose regarding therapy with RAS inhibition during the COVID-19 pandemic. …