Fei Wang
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View article: Assessment of aortic stiffness determinants including smoking status by a novel semiautomatic doppler ultrasound
Assessment of aortic stiffness determinants including smoking status by a novel semiautomatic doppler ultrasound Open
View article: RIOK2 kinase regulates the translocation of the FADD–RIPK1–Caspase-8 complex to the ER and the cleavage of Gasdermin D to drive pyroptosis
RIOK2 kinase regulates the translocation of the FADD–RIPK1–Caspase-8 complex to the ER and the cleavage of Gasdermin D to drive pyroptosis Open
View article: Exportin 1 inhibitor KPT‑330 reverses oxaliplatin resistance via p53 nuclear retention in colorectal cancer
Exportin 1 inhibitor KPT‑330 reverses oxaliplatin resistance via p53 nuclear retention in colorectal cancer Open
Despite the established clinical efficacy of oxaliplatin in colorectal cancer (CRC), resistance to this platinum‑based agent continues to pose a significant therapeutic challenge. Increased exportin 1 (XPO1) expression in CRC has been link…
View article: An Age-Structured Mathematical Model for Human Papillomavirus (HPV) and Cervical Cancer in the Presence of Vaccination and Treatment
An Age-Structured Mathematical Model for Human Papillomavirus (HPV) and Cervical Cancer in the Presence of Vaccination and Treatment Open
This study develops an age-structured mathematical model to investigate the dynamics of Human Papillomavirus (HPV) and cervical cancer progression in the presence of vaccination and treatment. The model stratifies the population into five …
View article: Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke
Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke Open
Chronic neuroinflammation is a major obstacle to post-stroke recovery, yet the underlying mechanisms, particularly the link between prolonged microglial activation and cholesterol metabolism, are not fully known. Here we show that ischaemi…
View article: Case Report: A novel heterozygous variant of the TCOF1 gene in Treacher Collins syndrome
Case Report: A novel heterozygous variant of the TCOF1 gene in Treacher Collins syndrome Open
Treacher Collins syndrome (TCS) is a craniofacial malformation caused by the abnormal development of the first and second pharyngeal arches during embryogenesis. While pathogenic variants in POLR1B , POLR1C , and POLR1D are implicated, the…
View article: Discovery of potent and selective peroxiredoxin 2 agonist natural products and derivatives against myocardial ischemia-reperfusion injury
Discovery of potent and selective peroxiredoxin 2 agonist natural products and derivatives against myocardial ischemia-reperfusion injury Open
View article: Effects of air pollutants on the incidence, progression, and mortality of idiopathic pulmonary fibrosis: a systematic review and meta-analysis
Effects of air pollutants on the incidence, progression, and mortality of idiopathic pulmonary fibrosis: a systematic review and meta-analysis Open
View article: Serum Pharmacology to Investigate the Active Components and Anti-inflammatory Mechanism of Lonicera japonica Thunb. and Shuangbei Syrup
Serum Pharmacology to Investigate the Active Components and Anti-inflammatory Mechanism of Lonicera japonica Thunb. and Shuangbei Syrup Open
Objective: To investigate the mechanism by which Lonicera japonica Thunb. ( L. japonica ), as a ministerial drug, it assists Shuangbei Syrup in exerting its anti-inflammatory effect. Materials and Methods: First, network pharmacology was u…
View article: Analysis of the clinical diagnostic efficacy of the novel serum markers lipase F, gastrokine 2 and the collagen X-type α1 chain in gastric cancer
Analysis of the clinical diagnostic efficacy of the novel serum markers lipase F, gastrokine 2 and the collagen X-type α1 chain in gastric cancer Open
Objective: To explore the application value of three novel serum markers, collagen X-type α1 chain (COL10A1), gastrokine 2 (GKN2), and lipase F (LIPF), in the diagnosis of gastric cancer. Methods: Differential markers of gastric cancer wer…
View article: Transcriptomic Profiling of Thermotolerant Sarcomyxa edulis PQ650759 Reveals the Key Genes and Pathways During Fruiting Body Formation
Transcriptomic Profiling of Thermotolerant Sarcomyxa edulis PQ650759 Reveals the Key Genes and Pathways During Fruiting Body Formation Open
Sarcomyxa edulis is a characteristic low-temperature, edible mushroom in Northeast China. It has a delicious taste and rich nutritional and medicinal value. S. edulis can undergo explosive fruiting, neat fruiting, and unified harvesting, m…
View article: From hormones to neurodegeneration: how FSH drives Alzheimer’s disease
From hormones to neurodegeneration: how FSH drives Alzheimer’s disease Open
The role and function of follicle-stimulating hormone in the gonads have been extremely studied. However, recent research has begun to explore the relationship between elevated follicle-stimulating hormone levels and the prevalence of extr…
View article: Serum sodium within the normal range and its U-shaped relationship with biological aging in U.S. adults
Serum sodium within the normal range and its U-shaped relationship with biological aging in U.S. adults Open
Background This cross-sectional study evaluated the correlation between serum sodium levels (135–145 mmol/L) and biological aging in U.S. adults. Biological age, derived from multi-system biomarkers, provides a more accurate assessment of …
View article: Mitochondrial Fusion Protein 2‐Modified Bone Marrow Mesenchymal Stem Cells Improved Hyperglycemia‐Induced Schwann Cell Injury via Regulating Mitochondria‐Associated Endoplasmic Reticulum Membranes
Mitochondrial Fusion Protein 2‐Modified Bone Marrow Mesenchymal Stem Cells Improved Hyperglycemia‐Induced Schwann Cell Injury via Regulating Mitochondria‐Associated Endoplasmic Reticulum Membranes Open
Objective High glucose damages rat Schwann cells (SCs), which is closely related to the dysfunction of mitochondria‐associated endoplasmic reticulum membranes (MAMs). Therefore, the present study aimed to investigate the protective effects…
View article: Characterization of the complete chloroplast genome of <i>Brunfelsia brasiliensis</i> (Spreng.) L.B.Sm. & Downs
Characterization of the complete chloroplast genome of <i>Brunfelsia brasiliensis</i> (Spreng.) L.B.Sm. & Downs Open
Brunfelsia brasiliensis (B. brasiliensis) (Spreng.) L.B.Sm. & Downs is a perennial evergreen shrub that is widely cultivated as an ornamental plant in tropical and subtropical regions. This study presents the complete chlorop…
View article: Frontispiece: Reductant‐Free Enantioselective <i>Aza</i>‐Reformatsky Reaction Enabled by Synergistic Visible Light Photocatalysis and Lewis Acid Catalysis
Frontispiece: Reductant‐Free Enantioselective <i>Aza</i>‐Reformatsky Reaction Enabled by Synergistic Visible Light Photocatalysis and Lewis Acid Catalysis Open
View article: Sotorasib-impaired degradation of NEU1 contributes to cardiac injury by inhibiting AKT signaling
Sotorasib-impaired degradation of NEU1 contributes to cardiac injury by inhibiting AKT signaling Open
View article: <scp>MK5</scp> Regulates Microglial Activation and Neuroinflammation in Experimental Stroke Models
<span>MK5</span> Regulates Microglial Activation and Neuroinflammation in Experimental Stroke Models Open
Objective Microglial activation plays a crucial role in neuroinflammation following ischemic stroke. This study was conducted to investigate the role and potential mechanisms of MK5 within microglial cells in the inflammatory response foll…
View article: Mechanisms and Potential of Antitumor Therapy With Natural Products Regulating Non‐Coding <scp>RNAs</scp>
Mechanisms and Potential of Antitumor Therapy With Natural Products Regulating Non‐Coding <span>RNAs</span> Open
Non‐coding RNAs (ncRNAs) are a distinctive class of RNA transcripts that have received extensive attention from the global scientific community due to their intricate and important roles in tumor malignancy. The dysregulated expression of …
View article: Evaluation of Tyromyces chioneus Production Using Sawdust Supplemented with Corncobs
Evaluation of Tyromyces chioneus Production Using Sawdust Supplemented with Corncobs Open
Tyromyces chioneus fruiting bodies could potentially be used for food and medicine; however, we still have limited knowledge about their optimal cultivation conditions and nutritional quality. In this study, we cultivated a wild strain of …
View article: Association between estimated glucose disposal rate with the all-cause and cause-specific mortality among the population with cardiometabolic syndrome
Association between estimated glucose disposal rate with the all-cause and cause-specific mortality among the population with cardiometabolic syndrome Open
View article: Synthetic Lethality of SHP2 and XIAP Suppresses Proliferation and Metastasis in <i>KRAS</i>‐mutant Nonsmall Cell Lung Cancer
Synthetic Lethality of SHP2 and XIAP Suppresses Proliferation and Metastasis in <i>KRAS</i>‐mutant Nonsmall Cell Lung Cancer Open
Kirsten rat sarcoma viral oncogene homolog ( KRAS ) mutations are associated with poor prognosis and poor response to standard therapeutic regimens in patients with nonsmall cell lung cancer (NSCLC). Identification of novel synthetic letha…
View article: LncRNA PCAT6 promotes progression and metastasis of colonic neuroendocrine carcinoma <i>via</i> MAPK pathway
LncRNA PCAT6 promotes progression and metastasis of colonic neuroendocrine carcinoma <i>via</i> MAPK pathway Open
BACKGROUND Colonic neuroendocrine carcinomas (NECs) are highly malignant and invasive with poor prognosis. Long noncoding RNAs (LncRNAs) participate in the tumorigenesis and metastasis of multiple cancers AIM To detect the roles and mechan…
View article: Protein kinase a suppresses antiproliferative effect of interferon-α in hepatocellular carcinoma by activation of protein tyrosine phosphatase SHP2
Protein kinase a suppresses antiproliferative effect of interferon-α in hepatocellular carcinoma by activation of protein tyrosine phosphatase SHP2 Open
View article: Cholesterol metabolism regulator SREBP2 inhibits HBV replication via suppression of HBx nuclear translocation
Cholesterol metabolism regulator SREBP2 inhibits HBV replication via suppression of HBx nuclear translocation Open
The intricate link between cholesterol metabolism and host immune responses is well recognized, but the specific mechanisms by which cholesterol biosynthesis influences hepatitis B virus (HBV) replication remain unclear. In this study, we …
View article: <i>In Situ</i> : Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems
<i>In Situ</i> : Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems Open
In situ microbial aerodynamic microneedles (MM-MNs) represent an autonomous transdermal drug delivery platform that utilizes the gas generated by microbial metabolism (e.g., H 2 , NO, and H 2 S) to propel drugs into deep tissues, surpassin…
View article: Efficient Adsorption of Metal Ions by Sulfur-Rich Conjugated Microporous Polymers Aerogels with High Selectivity
Efficient Adsorption of Metal Ions by Sulfur-Rich Conjugated Microporous Polymers Aerogels with High Selectivity Open
View article: Identification of immune characteristics between different subtypes in kidney renal clear cell carcinoma based on lysosome-related genes to assist immunotherapy
Identification of immune characteristics between different subtypes in kidney renal clear cell carcinoma based on lysosome-related genes to assist immunotherapy Open
Previous studies have revealed the essential role of lysosomes in human diseases, including cancer. However, there is a lack of in-depth systematic research on its function in kidney renal clear cell carcinoma (KIRC). In this project, we c…
View article: Calcium Channel Blocker Lacidipine Promotes Antitumor Immunity by Reprogramming Tryptophan Metabolism
Calcium Channel Blocker Lacidipine Promotes Antitumor Immunity by Reprogramming Tryptophan Metabolism Open
Dysfunction of calcium channels is involved in the development and progression of some cancers. However, it remains unclear the role of calcium channel inhibitors in tumor immunomodulation. Here, calcium channel blocker lacidipine is ident…
View article: Protective effect of xylosma congesta extract on renal injury in hyperuricemic rats
Protective effect of xylosma congesta extract on renal injury in hyperuricemic rats Open