Liang Xiao
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View article: Tamoxifen Modulates Spinal Cord Injury Repair via Ccl2/ccr2 Axis and Its Mechanisms
Tamoxifen Modulates Spinal Cord Injury Repair via Ccl2/ccr2 Axis and Its Mechanisms Open
Background:Spinal cord injury (SCI) represents a profoundly serious neurological disorder characterized by limited self-repair capabilities and accompanied by secondary inflammatory damage, rendering its treatment a pressing challenge in t…
View article: Pan-cancer analysis of PIEZO1: a promising biomarker for diagnosis, prognosis, and targeted therapies
Pan-cancer analysis of PIEZO1: a promising biomarker for diagnosis, prognosis, and targeted therapies Open
Introduction Piezo-type mechanosensitive channel component 1 (PIEZO1), a mechanically gated cation channel involved in calcium signaling, has been recognized as a potential oncogene in some cancers. However, its comprehensive pan-cancer ro…
View article: Functional divergence of G protein γ subunits drives plant vigor and improvement through the CPK28-PIP1;2 pathway in tomato
Functional divergence of G protein γ subunits drives plant vigor and improvement through the CPK28-PIP1;2 pathway in tomato Open
Maintaining robust plant vigor is essential for sustaining crop productivity, yet the precise roles and molecular underpinnings of G protein γ subunits in this process remain elusive. This study reveals that GGC1 is under selection during …
View article: Soil utilization of solid waste: Small strain characteristics of coastal cement soil modified by oyster shell powder under freeze-thaw cycle
Soil utilization of solid waste: Small strain characteristics of coastal cement soil modified by oyster shell powder under freeze-thaw cycle Open
The resource utilization of oyster shell powder (OSP) holds significant implications for solid waste disposal and global carbon cycle. This study investigates the effect of OSP on the small strain characteristics and microstructural mechan…
View article: Neutrophil-derived LL37 mediates IgA nephropathy via NETs-dependent mechanism
Neutrophil-derived LL37 mediates IgA nephropathy via NETs-dependent mechanism Open
IgAN is a common cause leading to end-stage renal disease. The deposition of pathogenic IgA in the glomerular mesangium is a critical step. However, the mechanisms of pathogenic IgA crossing the glomerular filtration barrier remain unclear…
View article: Development of a nomogram for predicting depression risk in patients with chronic kidney disease: an analysis of data from the US National Health and Nutrition Examination Survey, 2007–2014
Development of a nomogram for predicting depression risk in patients with chronic kidney disease: an analysis of data from the US National Health and Nutrition Examination Survey, 2007–2014 Open
Objectives Depression frequently occurs among individuals suffering from chronic kidney disease (CKD), diminishing life quality considerably while accelerating the disease course. This study aims to create a predictive model to identify pa…
View article: Soil Utilization of Solid Waste: Small Strain Characteristics of Coastal Cement Soil Modified by Oyster Shell Powder Under Freeze-Thaw Cycle
Soil Utilization of Solid Waste: Small Strain Characteristics of Coastal Cement Soil Modified by Oyster Shell Powder Under Freeze-Thaw Cycle Open
View article: Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis
Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis Open
Objective To compare the diagnostic effects of computed tomography (CT) and bronchoscopy guided biopsy on pulmonary nodules. Methods “Subject words + free words” were used to search four literature databases including Pubmed, Embase, Cochr…
View article: International standard of Traditional Chinese Medicine techniques: clinical guidelines for dysmenorrhea (2022).
International standard of Traditional Chinese Medicine techniques: clinical guidelines for dysmenorrhea (2022). Open
Dysmenorrhea is a common gynecological condition that is further divided into two categories, namely primary and secondary dysmenorrhea. Traditional Chinese Medicine (TCM) gives good clinical results for the treatment of dysmenorrhea based…
View article: Integrated large-scale metagenome assembly and multi-kingdom network analyses identify sex differences in the human nasal microbiome
Integrated large-scale metagenome assembly and multi-kingdom network analyses identify sex differences in the human nasal microbiome Open
View article: Evaluation of the outcomes of staging laparoscopy in intrahepatic cholangiocarcinoma patients undergoing surgical resection: a multicenter retrospective study in China
Evaluation of the outcomes of staging laparoscopy in intrahepatic cholangiocarcinoma patients undergoing surgical resection: a multicenter retrospective study in China Open
Aim: To evaluate the perioperative outcomes and postoperative survival of applying staging laparoscopy (SL) in intrahepatic cholangiocarcinoma (ICC) patients undergoing surgical resection. Methods: A retrospective analysis was performed on…
View article: Anlotinib reverses osimertinib resistance by inhibiting epithelial-to-mesenchymal transition and angiogenesis in non-small cell lung cancer
Anlotinib reverses osimertinib resistance by inhibiting epithelial-to-mesenchymal transition and angiogenesis in non-small cell lung cancer Open
In the present study, we aimed to investigate whether anlotinib reverses osimertinib resistance by inhibiting the formation of epithelial-mesenchymal transition (EMT) and angiogenesis. In a clinical case, anlotinib reversed osimertinib res…
View article: SNORD3A Regulates STING Transcription to Promote Ferroptosis in Acute Kidney Injury
SNORD3A Regulates STING Transcription to Promote Ferroptosis in Acute Kidney Injury Open
Acute kidney injury (AKI) signifies a sudden and prolonged decline in kidney function characterized by tubular cell death and interstitial inflammation. Small nucleolar RNAs (snoRNAs) play pivotal roles in oxidative stress and inflammation…
View article: 3D-printed biodegradable polycaprolactone rib implants with tissue-specific mechanical properties promote chest wall recovery by stimulating tissue fibrosis
3D-printed biodegradable polycaprolactone rib implants with tissue-specific mechanical properties promote chest wall recovery by stimulating tissue fibrosis Open
Here we developed a tripartite biodegradable rib implant with tissue-specific mechanical properties by employing polycaprolactone and a dual-structure-reinforced selective laser sintering (SLS) strategy. Computational simulation revealed t…
View article: Deep learning for cosmological parameter inference from a dark matter halo density field
Deep learning for cosmological parameter inference from a dark matter halo density field Open
We propose a lightweight deep convolutional neural network (lCNN) to estimate cosmological parameters from simulated three-dimensional dark matter (DM) halo distributions and associated statistics. The training dataset comprises 2000 reali…
View article: SIRT5-related lysine demalonylation of GSTP1 contributes to cardiomyocyte pyroptosis suppression in diabetic cardiomyopathy
SIRT5-related lysine demalonylation of GSTP1 contributes to cardiomyocyte pyroptosis suppression in diabetic cardiomyopathy Open
Sirtuin 5 (SIRT5), localized in the mitochondria, has been identified as a protein desuccinylase and demalonylase in the mitochondria since the depletion of SIRT5 boosted the global succinylation and malonylation of mitochondrial proteins.…
View article: Machine Learning Phenotyping and Gwas Reveal Genetic Basis of Cd Tolerance and Absorption in Jute
Machine Learning Phenotyping and Gwas Reveal Genetic Basis of Cd Tolerance and Absorption in Jute Open
View article: Table of Contents
Table of Contents Open
View article: Outer membrane vesicles induce the mussel plantigrade settlement via regulation of c-di-GMP
Outer membrane vesicles induce the mussel plantigrade settlement via regulation of c-di-GMP Open
Despite the importance of outer membrane vesicles (OMVs) in benthic animal settlement, the underlying molecular mechanism remains elusive. Here, the impact of OMVs and OMVs synthesis-related tolB gene in Mytilus coruscus plan…
View article: The study of antecedent clinical manifestations of hypertensive heart disease in cohort of hypertension
The study of antecedent clinical manifestations of hypertensive heart disease in cohort of hypertension Open
Hypertensive heart disease presents increasing morbidity and mortality worldwide, however, the data about its epidemics and its specific symptoms in hypertension patients is scarce. To assess the frequency and correlated symptoms of hypert…
View article: Alterations of B-Cell Subsets in Peripheral Blood from Adult Patients with Idiopathic Membranous Nephropathy
Alterations of B-Cell Subsets in Peripheral Blood from Adult Patients with Idiopathic Membranous Nephropathy Open
View article: Analysis of merged transcriptomic and genomic datasets to identify genes and pathways underlying residual feed intake in growing pigs
Analysis of merged transcriptomic and genomic datasets to identify genes and pathways underlying residual feed intake in growing pigs Open
Improvement of feed efficiency (FE) in pigs is an important milestone in order to reduce the economic and environmental impact of pig production. The goal of finding biomarkers for FE has persisted for decades. However, due to the complexi…
View article: AMPK Promotes Larval Metamorphosis of Mytilus coruscus
AMPK Promotes Larval Metamorphosis of Mytilus coruscus Open
Metamorphosis is a critical process in the transition from planktonic life to benthic life for marine invertebrates, which is accompanied by a large amount of energy consumption. Previous studies have proved that AMP-activated protein kina…
View article: A circular RNA, circPTPN14, increases MYC transcription by interacting with FUBP1 and exacerbates renal fibrosis
A circular RNA, circPTPN14, increases MYC transcription by interacting with FUBP1 and exacerbates renal fibrosis Open
View article: Role of Axl in target organ inflammation and damage due to hypertensive aortic remodeling
Role of Axl in target organ inflammation and damage due to hypertensive aortic remodeling Open
In this study, a brief, 2-wk period of hypertension in mice led to progressive aortic remodeling, an increase in pulse wave velocity, and evidence of renal injury, dysfunction, and albuminuria. This end-organ damage was associated with per…
View article: Identification of senescence-related subtypes, establishment of a prognosis model, and characterization of a tumor microenvironment infiltration in breast cancer
Identification of senescence-related subtypes, establishment of a prognosis model, and characterization of a tumor microenvironment infiltration in breast cancer Open
Breast cancer is a malignancy with the highest incidence and mortality in women worldwide. Senescence is a model of arrest in the cell cycle, which plays an important role in tumor progression, while the prognostic value of cellular senesc…
View article: Isolevuglandins disrupt PU.1-mediated C1q expression and promote autoimmunity and hypertension in systemic lupus erythematosus
Isolevuglandins disrupt PU.1-mediated C1q expression and promote autoimmunity and hypertension in systemic lupus erythematosus Open
View article: Peripheral blood T-cell subset and its clinical significance in lupus nephritis patients
Peripheral blood T-cell subset and its clinical significance in lupus nephritis patients Open
Objectives Lupus nephritis (LN) is a common and severe manifestation of SLE. Memory T (TM) cells have been implicated in the pathogenesis of SLE. This study aimed to investigate the clinical significance of T-cell subsets in a cohort of pa…
View article: Genetic Diversity Analysis of the Chinese Daur Ethnic Group in Heilongjiang Province by Complete Mitochondrial Genome Sequencing
Genetic Diversity Analysis of the Chinese Daur Ethnic Group in Heilongjiang Province by Complete Mitochondrial Genome Sequencing Open
Mitochondrial DNA (mtDNA) has the characteristics of maternal inheritance, high mutation rate, high copy number, and no recombination . As the most powerful tool for studying the origin and evolution of modern humans, mtDNA has great signi…
View article: Isolevuglandins disrupt PU.1-mediated C1q expression and promote autoimmunity and hypertension in systemic lupus erythematosus
Isolevuglandins disrupt PU.1-mediated C1q expression and promote autoimmunity and hypertension in systemic lupus erythematosus Open
We describe a mechanism responsible for systemic lupus erythematosus (SLE). In humans with SLE and in 2 SLE murine models, there was marked enrichment of isolevuglandin-adducted proteins (isoLG adducts) in monocytes and dendritic cells. We…